Kcnip3 Kv channel interacting protein 3, calsenilin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnip3provided by MGI
Official Full Name: Kv channel interacting protein 3, calsenilinprovided by MGI
Primary source: MGI:MGI:1929258
See related: Ensembl:ENSMUSG00000079056 AllianceGenome:MGI:1929258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Csen; DREAM; KChIP3; 4933407H12Rik
Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding activity; and transcription cis-regulatory region binding activity. Involved in protein localization to plasma membrane; regulation of potassium ion transmembrane transport; and response to magnesium ion. Acts upstream of or within several processes, including behavioral response to pain; negative regulation of transcription by RNA polymerase II; and sensory perception of pain. Located in cytosol and nucleus. Part of protein-DNA complex and voltage-gated potassium channel complex. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and spinal cord. Orthologous to human KCNIP3 (potassium voltage-gated channel interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 10.9), frontal lobe adult (RPKM 9.3) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 62.02 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (127298418..127364014, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (127456498..127522094, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteomic Profile of a Chronic Binge Ethanol Exposure Model.
Title: Proteomic Profile of a Chronic Binge Ethanol Exposure Model.
These results suggest that DREAM and probably other members of the neuronal calcium sensor family bind Cd2+ with an affinity that is superior to that for Ca2+ and the interactions between toxic Cd2+ and DREAM and other neuronal calcium sensors provide novel insight into the molecular mechanism of Cd2+ neurotoxicity.
Title: Cadmium association with DREAM promotes DREAM interactions with intracellular partners in a similar manner to its physiological ligand, calcium.
Pb(2+) binds to EF-hands in apo-DREAM (downstream regulatory element antagonist modulator) with a lower equilibrium dissociation constant. Based on the Trp169 emission and CD spectra, Pb(2+) association triggers changes in the protein secondary and tertiary structures that are analogous to those previously observed for Ca(2+)-bound protein.
Title: Pb(2+) Binds to Downstream Regulatory Element Antagonist Modulator (DREAM) and Modulates Its Interactions with Binding Partners: A Link between Neuronal Calcium Sensors and Pb(2+) Neurotoxicity.
calsenilin controls the activity of neuronal RyRs.
Title: Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.
DREAM inhibition markedly improves ATF6 processing in the hippocampus and that it might contribute to a delay in memory decline in Huntington mice.
Title: Inhibition of DREAM-ATF6 interaction delays onset of cognition deficit in a mouse model of Huntington's disease.
Genome-wide analysis of trigeminal neurons in daDREAM transgenic mice identified cathepsin L and the monoglyceride lipase as two new DREAM transcriptional targets related to pain.
Title: Transcriptional repressor DREAM regulates trigeminal noxious perception.
Our findings demonstrate for the first time that DREAM plays an important role in thrombosis and hemostasis in mice.
Title: DREAM plays an important role in platelet activation and thrombogenesis.
association of PS1 carboxyl peptide (residues 445-467, HL9) with DREAM is calcium dependent and stabilized by a cluster of three aromatic residues: F462 and F465 from PS1 and F252 from DREAM.
Title: Molecular insight of DREAM and presenilin 1 C-terminal fragment interactions.
DREAM plays an important role in structural plasticity in the hippocampus.
Title: Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice.
Terbium(III) binding preserves the folding state of DREAM with minimal changes to overall structure of DREAM.
Title: Characterization of the Photophysical, Thermodynamic, and Structural Properties of the Terbium(III)-DREAM Complex.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI413860 (e-PCR)
- UniSTS:164178

RH125117 (e-PCR)
- UniSTS:161939

MARC_16025-16026:1017084488:1 (e-PCR)
- UniSTS:267937

MARC_16027-16028:1017085829:1 (e-PCR)
- UniSTS:267938

Kcnip3 (e-PCR), detects polymorphism
- UniSTS:478913

Kcnip3 (e-PCR), detects polymorphism
- UniSTS:478921

Kcnip3 (e-PCR), detects polymorphism
- UniSTS:478922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables core promoter sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ion binding	EXP Inferred from Experiment more info	PubMed
enables magnesium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	EXP Inferred from Experiment more info	PubMed
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to magnesium ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-DNA complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calsenilin

Names: A-type potassium channel modulatory protein 3; DRE-antagonist modulator; calsenilin, presenilin binding protein, EF hand transcription factor; calsenilin/KChIP3 T+; calsenilin/KChIP3 T-; downstream regulatory element antagonist T+; downstream regulatory element antagonist T-; kv channel-interacting protein 3; potassium channel interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111331.1 → NP_001104801.1 calsenilin isoform b

See identical proteins and their annotated locations for NP_001104801.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

BC057329, DQ148500

Consensus CDS

CCDS50703.1

UniProtKB/TrEMBL

Q3TMU2, Q3YAA9

Related

ENSMUSP00000085896.6, ENSMUST00000088538.6

Conserved Domains (1) summary

COG5126
Location:55 → 219

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001291005.1 → NP_001277934.1 calsenilin isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site that results in translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is longer than isoform a.

Source sequence(s)

AF287732, BC057329, CJ148267

Consensus CDS

CCDS71139.1

UniProtKB/TrEMBL

A2AHT3

Related

ENSMUSP00000028850.9, ENSMUST00000028850.15

Conserved Domains (2) summary

COG5126
Location:109 → 273

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:194 → 265

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_019789.4 → NP_062763.2 calsenilin isoform a

See identical proteins and their annotated locations for NP_062763.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AF287732, BC057329, CJ148267

Consensus CDS

CCDS16703.1

UniProtKB/Swiss-Prot

Q924L0, Q99PH9, Q99PI0, Q99PI2, Q99PI3, Q9JHZ5, Q9QXT8

UniProtKB/TrEMBL

Q3TMU2, Q3YAB0

Related

ENSMUSP00000099504.5, ENSMUST00000103215.11

Conserved Domains (1) summary

COG5126
Location:81 → 245

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RNA

NR_110989.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 5' terminal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AK016721, BC057329

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

127298418..127364014 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239710.4 → XP_011238012.1 calsenilin isoform X1

UniProtKB/TrEMBL

Q3TMU2

Conserved Domains (1) summary

COG5126
Location:61 → 225

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]