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Sae1 SUMO1 activating enzyme subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 56459, updated on 5-Mar-2024

Summary

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Official Symbol
Sae1provided by MGI
Official Full Name
SUMO1 activating enzyme subunit 1provided by MGI
Primary source
MGI:MGI:1929264
See related
Ensembl:ENSMUSG00000052833 AllianceGenome:MGI:1929264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AOS1; Sua1; Uble1a; HSPC140; D7Ertd177e; 2400010M20Rik; 2610044L12Rik
Summary
Predicted to enable several functions, including ATP-dependent protein binding activity; SUMO activating enzyme activity; and protein C-terminus binding activity. Predicted to be involved in positive regulation of protein sumoylation and protein sumoylation. Predicted to be located in nucleoplasm. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in genitourinary system. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 52.3), placenta adult (RPKM 35.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A2; 7 8.88 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16054161..16121821, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16320236..16387896, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3699 Neighboring gene InaF motif containing 1 Neighboring gene coiled-coil domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16880265-16880374 Neighboring gene STARR-positive B cell enhancer ABC_E6516 Neighboring gene STARR-seq mESC enhancer starr_18129 Neighboring gene STARR-seq mESC enhancer starr_18130 Neighboring gene BCL2 binding component 3 Neighboring gene predicted gene, 57781 Neighboring gene STARR-seq mESC enhancer starr_18132 Neighboring gene STARR-positive B cell enhancer ABC_E4898 Neighboring gene STARR-seq mESC enhancer starr_18133 Neighboring gene zinc finger CCCH-type containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E347 Neighboring gene transmembrane protein 160

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression and regulation of the mammalian SUMO-1 E1 enzyme. Azuma Y, et al. FASEB J, 2001 Aug. PMID 11481243
  2. Biotin-ubiquitin tagging of mammalian proteins in Escherichia coli. Wang T, et al. Protein Expr Purif, 2003 Jul. PMID 12821332
  3. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Su HL, et al. Gene, 2002 Aug 21. PMID 12383504
  4. Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis. Ban R, et al. Genes Cells, 2011 Jun. PMID 21554500
  5. The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle. Aweida D, et al. EMBO Rep, 2022 Dec 6. PMID 36278411, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to SUMO activating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables small protein activating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SUMO activating enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SUMO activating enzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SUMO-activating enzyme subunit 1
Names
SUMO-1 activating enzyme subunit 1
ubiquitin-like (sentrin) activating enzyme E1A
ubiquitin-like 1 (sentrin) activating enzyme E1A
ubiquitin-like 1 (sentrin) activating enzyme subunit 1
ubiquitin-like 1-activating enzyme E1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285891.1 → NP_001272820.1  SUMO-activating enzyme subunit 1 isoform a

    See identical proteins and their annotated locations for NP_001272820.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC164880, AK162789, BB838763, BC068164
    Consensus CDS
    CCDS20848.1
    UniProtKB/Swiss-Prot
    Q3TRG9, Q3TWJ0, Q9CSW9, Q9R1T2
    Related
    ENSMUSP00000147409.2, ENSMUST00000210999.2
    Conserved Domains (2) summary
    cd01492
    Location:20 → 345
    Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:23 → 338
    ThiF; ThiF family

  2. NM_001285892.1 → NP_001272821.1  SUMO-activating enzyme subunit 1 isoform b

    See identical proteins and their annotated locations for NP_001272821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC164880, AK011772, AK162789, BB838763
    Consensus CDS
    CCDS85221.1
    UniProtKB/Swiss-Prot
    Q9R1T2
    Related
    ENSMUSP00000147771.2, ENSMUST00000211741.2
    Conserved Domains (2) summary
    cd01492
    Location:20 → 173
    Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:23 → 171
    ThiF; ThiF family

  3. NM_019748.3 → NP_062722.1  SUMO-activating enzyme subunit 1 isoform a

    See identical proteins and their annotated locations for NP_062722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC164880, BB838763, BC068164
    Consensus CDS
    CCDS20848.1
    UniProtKB/Swiss-Prot
    Q3TRG9, Q3TWJ0, Q9CSW9, Q9R1T2
    Related
    ENSMUSP00000092409.4, ENSMUST00000094815.5
    Conserved Domains (2) summary
    cd01492
    Location:20 → 345
    Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:23 → 338
    ThiF; ThiF family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    16054161..16121821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250653.2 → XP_011248955.1  SUMO-activating enzyme subunit 1 isoform X1

    Conserved Domains (1) summary
    cd01492
    Location:20 → 173
    Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1T2.1 GenPept UniProtKB/Swiss-Prot:Q9R1T2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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