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Ykt6 YKT6 v-SNARE homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 56418, updated on 5-Mar-2024

Summary

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Official Symbol
Ykt6provided by MGI
Official Full Name
YKT6 v-SNARE homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1927550
See related
Ensembl:ENSMUSG00000002741 AllianceGenome:MGI:1927550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610042I15Rik; 1810013M05Rik
Summary
Predicted to enable SNAP receptor activity and protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde transport, endosome to Golgi; and vesicle docking involved in exocytosis. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in several cellular components, including Golgi apparatus; dendrite; and neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to be part of SNARE complex. Is expressed in coelomic epithelium of testis; embryo; and ovary. Orthologous to human YKT6 (YKT6 v-SNARE homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 32.6), CNS E14 (RPKM 26.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 3.89 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5905779..5917780)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5955758..5967780)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11967 Neighboring gene glucokinase Neighboring gene STARR-seq mESC enhancer starr_28446 Neighboring gene STARR-positive B cell enhancer ABC_E6947 Neighboring gene predicted gene, 53665 Neighboring gene calcium/calmodulin-dependent protein kinase II, beta Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5900191-5900374 Neighboring gene STARR-positive B cell enhancer ABC_E11764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5917894-5918003 Neighboring gene NudC domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_28452 Neighboring gene ribosomal protein S15A, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. McNew JA, et al. J Biol Chem, 1997 Jul 11. PMID 9211930
  2. Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport. Zhang T, et al. J Biol Chem, 2001 Jul 20. PMID 11323436
  3. Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad. McClive PJ, et al. Genesis, 2003 Oct. PMID 14595844
  4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking involved in exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking involved in exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in vesicle targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle targeting ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in basal dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
synaptobrevin homolog YKT6
Names
YKT6 homolog
prenylated SNARE protein (Ykt6)
NP_062635.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019661.5 → NP_062635.2  synaptobrevin homolog YKT6

    See identical proteins and their annotated locations for NP_062635.2

    Status: VALIDATED

    Source sequence(s)
    AL645469
    Consensus CDS
    CCDS24410.1
    UniProtKB/Swiss-Prot
    O88595, Q9CQW1
    Related
    ENSMUSP00000002818.9, ENSMUST00000002818.9
    Conserved Domains (3) summary
    COG5143
    Location:3 → 198
    SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
    cd15867
    Location:136 → 195
    R-SNARE_YKT6; SNARE motif of YKT6
    pfam13774
    Location:44 → 107
    Longin; Regulated-SNARE-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    5905779..5917780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQW1.1 GenPept UniProtKB/Swiss-Prot:Q9CQW1

Gene LinkOut

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