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Noa1 nitric oxide associated 1 [ Mus musculus (house mouse) ]

Gene ID: 56412, updated on 7-Apr-2024

Summary

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Official Symbol
Noa1provided by MGI
Official Full Name
nitric oxide associated 1provided by MGI
Primary source
MGI:MGI:1914306
See related
Ensembl:ENSMUSG00000036285 AllianceGenome:MGI:1914306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AtNOS1; mAtNOS1; 2610024G14Rik
Summary
Predicted to enable GTP binding activity. Involved in mitochondrial translation; regulation of cell death; and regulation of cellular respiration. Located in mitochondrial inner membrane. Is expressed in several structures, including humerus cartilage condensation; jaw; nervous system; otic capsule; and skeleton. Orthologous to human NOA1 (nitric oxide associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 14.8), ovary adult (RPKM 11.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.3; 5 41.64 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (77442016..77458276, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (77294169..77310413, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:77666066-77666366 Neighboring gene predicted gene, 19060 Neighboring gene STARR-positive B cell enhancer ABC_E3585 Neighboring gene STARR-seq mESC enhancer starr_13466 Neighboring gene STARR-seq mESC enhancer starr_13469 Neighboring gene STARR-positive B cell enhancer mm9_chr5:77704983-77705284 Neighboring gene microRNA 5098 Neighboring gene RE1-silencing transcription factor Neighboring gene STARR-seq mESC enhancer starr_13474 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide B Neighboring gene insulin-like growth factor binding protein 7 Neighboring gene predicted gene, 34648

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Binding to G-quadruplex RNA activates the mitochondrial GTPase NOA1. Al-Furoukh N, et al. Biochim Biophys Acta, 2013 Dec. PMID 23933583
  2. NOA1, a novel ClpXP substrate, takes an unexpected nuclear detour prior to mitochondrial import. Al-Furoukh N, et al. PLoS One, 2014. PMID 25072814, Free PMC Article
  3. Nitric oxide-associated protein 1 (NOA1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes. Heidler J, et al. J Biol Chem, 2011 Sep 16. PMID 21771794, Free PMC Article
  4. mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells. Parihar A, et al. Life Sci, 2008 May 23. PMID 18456285
  5. Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate. Zemojtel T, et al. FEBS Lett, 2006 Jan 23. PMID 16380119

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial ribosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with matrix side of mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nitric oxide-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429035.1 → NP_001415964.1  nitric oxide-associated protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC141469

  2. NM_001429036.1 → NP_001415965.1  nitric oxide-associated protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC141469

  3. NM_001429037.1 → NP_001415966.1  nitric oxide-associated protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC141469

  4. NM_001429038.1 → NP_001415967.1  nitric oxide-associated protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC141469

  5. NM_001429039.1 → NP_001415968.1  nitric oxide-associated protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC141469

  6. NM_001429040.1 → NP_001415969.1  nitric oxide-associated protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC141469

  7. NM_019836.4 → NP_062810.1  nitric oxide-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_062810.1

    Status: VALIDATED

    Source sequence(s)
    AC141469
    Consensus CDS
    CCDS19373.1
    UniProtKB/Swiss-Prot
    Q3T996, Q3U044, Q99JU4, Q9JJG9
    UniProtKB/TrEMBL
    Q8BMY1
    Related
    ENSMUSP00000045948.9, ENSMUST00000047860.9
    Conserved Domains (4) summary
    cd01855
    Location:180 → 396
    YqeH; Circularly permuted YqeH GTPase
    PRK13796
    Location:140 → 655
    PRK13796; GTPase YqeH; Provisional
    pfam11221
    Location:79 → 120
    Med21; Subunit 21 of Mediator complex
    pfam15444
    Location:33 → 129
    TMEM247; Transmembrane protein 247

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    77442016..77458276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535153.5 → XP_006535216.1  nitric oxide-associated protein 1 isoform X1

    Conserved Domains (3) summary
    cd01855
    Location:180 → 396
    YqeH; Circularly permuted YqeH GTPase
    TIGR03597
    Location:142 → 616
    GTPase_YqeH; ribosome biogenesis GTPase YqeH
    pfam15236
    Location:83 → 119
    CCDC66; Coiled-coil domain-containing protein 66

  2. XM_011249546.4 → XP_011247848.1  nitric oxide-associated protein 1 isoform X2

    Conserved Domains (2) summary
    cd01855
    Location:180 → 396
    YqeH; Circularly permuted YqeH GTPase
    pfam15236
    Location:83 → 119
    CCDC66; Coiled-coil domain-containing protein 66
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJG9.1 GenPept UniProtKB/Swiss-Prot:Q9JJG9

Gene LinkOut

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