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Morf4l2 mortality factor 4 like 2 [ Mus musculus (house mouse) ]

Gene ID: 56397, updated on 5-Mar-2024

Summary

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Official Symbol
Morf4l2provided by MGI
Official Full Name
mortality factor 4 like 2provided by MGI
Primary source
MGI:MGI:1927167
See related
Ensembl:ENSMUSG00000031422 AllianceGenome:MGI:1927167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrgx; Sid393p; mKIAA0026; 2410017O14Rik
Summary
Predicted to be involved in heterochromatin assembly and histone modification. Predicted to act upstream of or within DNA repair and regulation of growth. Predicted to be located in nucleolus; nucleoplasm; and plasma membrane. Predicted to be part of NuA4 histone acetyltransferase complex. Is expressed in genitourinary system and retina. Orthologous to human MORF4L2 (mortality factor 4 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 441.2), CNS E11.5 (RPKM 149.5) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F1; X 59.1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135633691..135644435, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136732942..136743686, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene acyl-protein thioesterase 1 pseudogene Neighboring gene predicted gene, 39536 Neighboring gene transcription elongation factor A (SII)-like 1 Neighboring gene STARR-seq mESC enhancer starr_47978 Neighboring gene STARR-positive B cell enhancer ABC_E3262 Neighboring gene STARR-positive B cell enhancer ABC_E11056 Neighboring gene cDNA sequence BC065397 Neighboring gene glycine receptor, alpha 4 subunit Neighboring gene predicted gene, 54085 Neighboring gene STARR-seq mESC enhancer starr_47979 Neighboring gene proteolipid protein (myelin) 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MrgX is not essential for cell growth and development in the mouse. Tominaga K, et al. Mol Cell Biol, 2005 Jun. PMID 15923606, Free PMC Article
  2. Conservation of the MORF4 related gene family: identification of a new chromo domain subfamily and novel protein motif. Bertram MJ, et al. Gene, 2001 Mar 21. PMID 11290425
  3. HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis. Brandsma I, et al. Cell Rep, 2019 Jun 25. PMID 31242413
  4. Hdac6 regulates Tip60-p400 function in stem cells. Chen PB, et al. Elife, 2013 Dec 3. PMID 24302573, Free PMC Article
  5. The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. Jacquet K, et al. Mol Cell, 2016 May 5. PMID 27153538, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mortality factor 4-like protein 2
Names
MORF-related gene X protein
sid 393
transcription factor-like protein Mrgx

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168225.1 → NP_001161697.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001161697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
    Source sequence(s)
    AK160012, AL671887, BC075653
    Consensus CDS
    CCDS30422.1
    UniProtKB/Swiss-Prot
    A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
    UniProtKB/TrEMBL
    Q3TME1, Q3U6G8
    Related
    ENSMUSP00000126363.2, ENSMUST00000166930.8
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG

  2. NM_001168226.1 → NP_001161698.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001161698.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
    Source sequence(s)
    AK160012, AL671887, BC075653, BY141735
    Consensus CDS
    CCDS30422.1
    UniProtKB/Swiss-Prot
    A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
    UniProtKB/TrEMBL
    Q3TME1, Q3U6G8
    Related
    ENSMUSP00000108722.4, ENSMUST00000080411.13
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG

  3. NM_001168227.1 → NP_001161699.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001161699.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
    Source sequence(s)
    AK160012, AL671887, BC075653
    Consensus CDS
    CCDS30422.1
    UniProtKB/Swiss-Prot
    A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
    UniProtKB/TrEMBL
    Q3TME1, Q3U6G8
    Related
    ENSMUSP00000129774.2, ENSMUST00000164609.8
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG

  4. NM_001168228.1 → NP_001161700.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001161700.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
    Source sequence(s)
    AK161610, AL671887, BC075653
    Consensus CDS
    CCDS30422.1
    UniProtKB/Swiss-Prot
    A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
    UniProtKB/TrEMBL
    Q3TME1, Q3U6G8
    Related
    ENSMUSP00000108720.2, ENSMUST00000113097.8
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG

  5. NM_001168229.1 → NP_001161701.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001161701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
    Source sequence(s)
    AK160012, AL671887, BC075653, BY141735
    Consensus CDS
    CCDS30422.1
    UniProtKB/Swiss-Prot
    A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
    UniProtKB/TrEMBL
    Q3TME1, Q3U6G8
    Related
    ENSMUSP00000132643.2, ENSMUST00000169418.8
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG

  6. NM_001168230.1 → NP_001161702.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001161702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
    Source sequence(s)
    AK161610, AL671887, BC075653
    Consensus CDS
    CCDS30422.1
    UniProtKB/Swiss-Prot
    A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
    UniProtKB/TrEMBL
    Q3TME1, Q3U6G8
    Related
    ENSMUSP00000131909.2, ENSMUST00000166478.8
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG

  7. NM_019768.4 → NP_062742.4  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_062742.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 7 encode the same protein.
    Source sequence(s)
    AK161610, BC075653
    Consensus CDS
    CCDS30422.1
    UniProtKB/Swiss-Prot
    A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
    UniProtKB/TrEMBL
    Q3TME1, Q3U6G8
    Related
    ENSMUSP00000033797.7, ENSMUST00000033797.13
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    135633691..135644435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528584.3 → XP_006528647.1  mortality factor 4-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006528647.1

    UniProtKB/Swiss-Prot
    A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
    UniProtKB/TrEMBL
    Q3TME1, Q3U6G8
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0Q4.1 GenPept UniProtKB/Swiss-Prot:Q9R0Q4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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