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Letm1 leucine zipper-EF-hand containing transmembrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 56384, updated on 11-Apr-2024

Summary

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Official Symbol
Letm1provided by MGI
Official Full Name
leucine zipper-EF-hand containing transmembrane protein 1provided by MGI
Primary source
MGI:MGI:1932557
See related
Ensembl:ENSMUSG00000005299 AllianceGenome:MGI:1932557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KHE
Summary
Enables calcium:proton antiporter activity. Involved in cellular calcium ion homeostasis and protein complex oligomerization. Located in mitochondrial inner membrane. Is expressed in gonad and seminiferous cord. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 18.7), colon adult (RPKM 16.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Letm1 in Genome Data Viewer
Location:
5 B2; 5 17.83 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33897017..33940061, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33739673..33782717, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34000710-34000897 Neighboring gene STARR-seq mESC enhancer starr_12827 Neighboring gene transmembrane protein 129 Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene Fgfr3 5' regulatory region Neighboring gene fibroblast growth factor receptor 3 Neighboring gene STARR-seq mESC enhancer starr_12830 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6319 Neighboring gene ATP synthase subunit g, mitochondrial pseudogene Neighboring gene nuclear receptor binding SET domain protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34194226-34194436 Neighboring gene microRNA 7024 Neighboring gene negative elongation factor complex member A, Whsc2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress. Huang E, et al. Nat Commun, 2017 Nov 9. PMID 29123128, Free PMC Article
  2. Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca(2+)/H(+) antiporter. Shao J, et al. Sci Rep, 2016 Sep 27. PMID 27669901, Free PMC Article
  3. Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Jiang D, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716663, Free PMC Article
  4. Endoplasmic reticulum potassium-hydrogen exchanger and small conductance calcium-activated potassium channel activities are essential for ER calcium uptake in neurons and cardiomyocytes. Kuum M, et al. J Cell Sci, 2012 Feb 1. PMID 22331352
  5. LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation. Doonan PJ, et al. FASEB J, 2014 Nov. PMID 25077561, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This paper's findings delineate a mechanism by which PINK1 regulates mitochondrial Ca(2+) level through LETM1 and suggest a model by which PINK1 loss leads to deficient phosphorylation of LETM1 and impaired mitochondrial Ca(2+) transport.
    Title: PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress.
  2. Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics
    Title: LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.
  3. Data indicate that cellular Letm1 knockdown reduced Ca(2+)mito uptake, H(+)mito extrusion and impaired mitochondrial ATP generation capacity.
    Title: Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium:proton antiporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calcium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium export from the mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium export from the mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium export from the mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cristae formation ISO
Inferred from Sequence Orthology
more info
  
involved_in inner mitochondrial membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitochondrial calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein hexamerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cellular hyperosmotic salinity response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial proton/calcium exchanger protein
Names
LETM1 and EF-hand domain-containing protein 1, mitochondrial
electroneutral mitochondrial K(+)/H(+)exchanger

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019694.2 → NP_062668.1  mitochondrial proton/calcium exchanger protein precursor

    See identical proteins and their annotated locations for NP_062668.1

    Status: VALIDATED

    Source sequence(s)
    AF061026, AK163499, BQ178952, BY110340, BY243359
    Consensus CDS
    CCDS19207.1
    UniProtKB/Swiss-Prot
    Q5PQC5, Q7TMK8, Q80ZX6, Q8CGJ3, Q8K5E5, Q9Z2I0
    Related
    ENSMUSP00000005431.6, ENSMUST00000005431.6
    Conserved Domains (1) summary
    pfam07766
    Location:154 → 409
    LETM1; LETM1-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    33897017..33940061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504034.5 → XP_006504097.1  mitochondrial proton/calcium exchanger protein isoform X1

    Conserved Domains (1) summary
    pfam07766
    Location:2 → 237
    LETM1; LETM1-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2I0.1 GenPept UniProtKB/Swiss-Prot:Q9Z2I0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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