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Rab9 RAB9, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 56382, updated on 7-Apr-2024

Summary

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Official Symbol
Rab9provided by MGI
Official Full Name
RAB9, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1890695
See related
Ensembl:ENSMUSG00000079316 AllianceGenome:MGI:1890695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab9a; Sid6061p; 2410064E05Rik
Summary
Enables identical protein binding activity. Predicted to be involved in several processes, including negative regulation by host of symbiont catalytic activity; positive regulation of exocytosis; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within protein transport. Located in cytoplasmic vesicle membrane and melanosome. Orthologous to human RAB9A (RAB9A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 21.4), liver E18 (RPKM 14.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F5; X 77.47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (165240247..165262863, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (166457251..166479867, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene glycoprotein m6b Neighboring gene OFD1, centriole and centriolar satellite protein Neighboring gene STARR-positive B cell enhancer ABC_E11806 Neighboring gene trafficking protein particle complex 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:162917789-162917898 Neighboring gene family with sequence similarity 154, member A pseudogene Neighboring gene predicted gene 15223

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. Saito T, et al. J Clin Invest, 2019 Feb 1. PMID 30511961, Free PMC Article
  2. Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis. Mareninova OA, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 34610499, Free PMC Article
  3. Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart. Nah J, et al. Cardiovasc Res, 2022 Sep 20. PMID 35018428, Free PMC Article
  4. Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2. Zhang Z, et al. Structure, 2014 Oct 7. PMID 25220469
  5. Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins. Zhao H, et al. Biochem Biophys Res Commun, 2002 May 10. PMID 12051767

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress.
    Title: IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress.
  2. Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.
    Title: Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.
  3. Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.
    Title: Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.
  4. Mitophagy mediated through the Ulk1/Rab9/Rip1/Drp1 pathway protected the heart against ischemia by maintaining healthy mitochondria.
    Title: An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia.
  5. Crystal structure of the Rab9A-RUTBC2 Rab-binding domain complex reveals that the hypervariable region of Rab9A is not required for RUTBC2 binding.
    Title: Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rab protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation by host of symbiont catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in melanosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-9A
Names
SID 99
rab-9A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019773.2 → NP_062747.1  ras-related protein Rab-9A

    See identical proteins and their annotated locations for NP_062747.1

    Status: VALIDATED

    Source sequence(s)
    AK017301, AL672174
    Consensus CDS
    CCDS30527.1
    UniProtKB/Swiss-Prot
    Q9R0M6
    UniProtKB/TrEMBL
    A2AFP5, Q0PD48
    Related
    ENSMUSP00000123325.2, ENSMUST00000112091.9
    Conserved Domains (1) summary
    cd04116
    Location:3 → 172
    Rab9; Rab GTPase family 9 (Rab9)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    165240247..165262863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162049.1 → XP_036017942.1  ras-related protein Rab-9A isoform X1

    UniProtKB/Swiss-Prot
    Q9R0M6
    UniProtKB/TrEMBL
    A2AFP5, Q0PD48
    Conserved Domains (1) summary
    cd04116
    Location:3 → 172
    Rab9; Rab GTPase family 9 (Rab9)

  2. XM_036162048.1 → XP_036017941.1  ras-related protein Rab-9A isoform X1

    UniProtKB/Swiss-Prot
    Q9R0M6
    UniProtKB/TrEMBL
    A2AFP5, Q0PD48
    Conserved Domains (1) summary
    cd04116
    Location:3 → 172
    Rab9; Rab GTPase family 9 (Rab9)

  3. XM_006528922.1 → XP_006528985.1  ras-related protein Rab-9A isoform X1

    See identical proteins and their annotated locations for XP_006528985.1

    UniProtKB/Swiss-Prot
    Q9R0M6
    UniProtKB/TrEMBL
    A2AFP5, Q0PD48
    Conserved Domains (1) summary
    cd04116
    Location:3 → 172
    Rab9; Rab GTPase family 9 (Rab9)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0M6.1 GenPept UniProtKB/Swiss-Prot:Q9R0M6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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