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Apip APAF1 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 56369, updated on 5-Mar-2024

Summary

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Official Symbol
Apipprovided by MGI
Official Full Name
APAF1 interacting proteinprovided by MGI
Primary source
MGI:MGI:1926788
See related
Ensembl:ENSMUSG00000010911 AllianceGenome:MGI:1926788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APIP2; CGI-29; Mmrp19
Summary
Predicted to enable identical protein binding activity; methylthioribulose 1-phosphate dehydratase activity; and zinc ion binding activity. Involved in regulation of ERK1 and ERK2 cascade. Acts upstream of or within negative regulation of apoptotic process. Predicted to be active in cytoplasm. Orthologous to human APIP (APAF1 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 17.9), limb E14.5 (RPKM 12.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Apip in Genome Data Viewer
Location:
2 E2; 2 54.29 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (102904020..102922994)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103073675..103092649)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9522 Neighboring gene STARR-positive B cell enhancer ABC_E2632 Neighboring gene predicted gene, 34483 Neighboring gene STARR-positive B cell enhancer ABC_E5951 Neighboring gene STARR-positive B cell enhancer ABC_E5952 Neighboring gene pyruvate dehydrogenase complex, component X Neighboring gene STARR-positive B cell enhancer mm9_chr2:102913613-102913914 Neighboring gene STARR-seq mESC enhancer starr_05263 Neighboring gene STARR-seq mESC enhancer starr_05264 Neighboring gene STARR-seq mESC enhancer starr_05265 Neighboring gene predicted gene 13869 Neighboring gene ets homologous factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Suppression of hypoxic cell death by APIP-induced sustained activation of AKT and ERK1/2. Cho DH, et al. Oncogene, 2007 Apr 26. PMID 17086211
  2. Cardioprotective role of APIP in myocardial infarction through ADORA2B. Lim B, et al. Cell Death Dis, 2019 Jul 1. PMID 31263105, Free PMC Article
  3. APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis. Hong SH, et al. Oncotarget, 2016 Apr 19. PMID 26942872, Free PMC Article
  4. Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein. Cho DH, et al. J Biol Chem, 2004 Sep 17. PMID 15262985
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylthioribulose 1-phosphate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylthioribulose 1-phosphate dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-methionine salvage from methylthioadenosine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-methionine salvage from methylthioadenosine ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methylthioribulose-1-phosphate dehydratase
Names
MTRu-1-P dehydratase
monocyte macrophage 19
monocyte/macrophage protein 19
probable methylthioribulose-1-phosphate dehydratase
NP_001342402.1
NP_001342403.1
NP_062709.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355473.1 → NP_001342402.1  methylthioribulose-1-phosphate dehydratase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL954375
    Conserved Domains (1) summary
    TIGR03328
    Location:27 → 212
    salvage_mtnB; methylthioribulose-1-phosphate dehydratase

  2. NM_001355474.1 → NP_001342403.1  methylthioribulose-1-phosphate dehydratase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL954375
    Related
    ENSMUST00000124540.8
    Conserved Domains (1) summary
    cl00214
    Location:1 → 154
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

  3. NM_019735.4 → NP_062709.3  methylthioribulose-1-phosphate dehydratase isoform 1

    See identical proteins and their annotated locations for NP_062709.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK077705, AK145450, AV060627
    Consensus CDS
    CCDS16474.1
    UniProtKB/Swiss-Prot
    Q8BP46, Q9WVQ5
    Related
    ENSMUSP00000011055.7, ENSMUST00000011055.7
    Conserved Domains (1) summary
    TIGR03328
    Location:27 → 225
    salvage_mtnB; methylthioribulose-1-phosphate dehydratase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    102904020..102922994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVQ5.1 GenPept UniProtKB/Swiss-Prot:Q9WVQ5

Gene LinkOut

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