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Cyb561d2 cytochrome b-561 domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 56368, updated on 5-Mar-2024

Summary

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Official Symbol
Cyb561d2provided by MGI
Official Full Name
cytochrome b-561 domain containing 2provided by MGI
Primary source
MGI:MGI:1929280
See related
Ensembl:ENSMUSG00000037190 AllianceGenome:MGI:1929280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsp10
Summary
Enables heme binding activity and transmembrane ascorbate ferrireductase activity. Predicted to be involved in ascorbate homeostasis. Located in endoplasmic reticulum and vesicle. Is expressed in Meckel's cartilage; genitourinary system; lower leg mesenchyme; skeleton; and thymus. Orthologous to human CYB561D2 (cytochrome b561 family member D2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 16.7), adrenal adult (RPKM 15.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 58.12 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107416210..107419392, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107539005..107542193, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 2 Neighboring gene predicted gene, 34037 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107417059-107417168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107423725-107423834 Neighboring gene STARR-positive B cell enhancer ABC_E10583 Neighboring gene STARR-positive B cell enhancer ABC_E10584 Neighboring gene transmembrane protein 115 Neighboring gene STARR-positive B cell enhancer ABC_E3857 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene zinc finger, MYND domain containing 10 Neighboring gene predicted gene, 34106

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spectral characterization of the recombinant mouse tumor suppressor 101F6 protein. Bérczi A, et al. Eur Biophys J, 2010 Jul. PMID 19943161
  2. Involvement of 101F6, a homologue of cytochrome b561, in the reduction of ferric ions. Mizutani A, et al. J Biochem, 2007 Dec. PMID 17938141
  3. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Lerman MI, et al. Cancer Res, 2000 Nov 1. PMID 11085536
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane ascorbate ferrireductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane monodehydroascorbate reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ascorbate homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane reductase CYB561D2
Names
cytochrome b561 domain-containing protein 2
gene for 101F6 protein
putative tumor suppressor protein 101F6
transmembrane ascorbate ferrireductase
tumor suppressor, region 10
NP_001344218.1
NP_001344219.1
NP_001344220.1
NP_062694.1
XP_006511839.1
XP_030100321.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357289.1 → NP_001344218.1  transmembrane reductase CYB561D2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AF131206, AL672219
    Consensus CDS
    CCDS23491.1
    UniProtKB/Swiss-Prot
    Q3TRQ1, Q9WUE3
    Related
    ENSMUSP00000141723.2, ENSMUST00000195235.6
    Conserved Domains (1) summary
    cd08761
    Location:25 → 205
    Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

  2. NM_001357290.1 → NP_001344219.1  transmembrane reductase CYB561D2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL672219
    Conserved Domains (1) summary
    cd08761
    Location:9 → 171
    Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

  3. NM_001357291.1 → NP_001344220.1  transmembrane reductase CYB561D2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AA756426, AL672219
    Conserved Domains (1) summary
    cd08761
    Location:1 → 154
    Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

  4. NM_019720.4 → NP_062694.1  transmembrane reductase CYB561D2 isoform a

    See identical proteins and their annotated locations for NP_062694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL672219
    Consensus CDS
    CCDS23491.1
    UniProtKB/Swiss-Prot
    Q3TRQ1, Q9WUE3
    Related
    ENSMUSP00000044093.4, ENSMUST00000041459.9
    Conserved Domains (1) summary
    cd08761
    Location:25 → 205
    Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107416210..107419392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244461.2 → XP_030100321.1  transmembrane reductase CYB561D2 isoform X1

    Conserved Domains (1) summary
    cd08761
    Location:91 → 253
    Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

  2. XM_006511776.5 → XP_006511839.1  transmembrane reductase CYB561D2 isoform X2

    See identical proteins and their annotated locations for XP_006511839.1

    UniProtKB/Swiss-Prot
    Q3TRQ1, Q9WUE3
    Conserved Domains (1) summary
    cd08761
    Location:25 → 205
    Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUE3.1 GenPept UniProtKB/Swiss-Prot:Q9WUE3

Gene LinkOut

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