U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acot9 acyl-CoA thioesterase 9 [ Mus musculus (house mouse) ]

Gene ID: 56360, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Acot9provided by MGI
Official Full Name
acyl-CoA thioesterase 9provided by MGI
Primary source
MGI:MGI:1928939
See related
Ensembl:ENSMUSG00000025287 AllianceGenome:MGI:1928939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U8; p48; MTE-2; Acate2; MT-ACT48; 0610041P13Rik
Summary
Enables acetyl-CoA hydrolase activity and palmitoyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and short-chain fatty acid metabolic process. Located in mitochondrial matrix. Is expressed in dorsal root ganglion; trigeminal ganglion; and vagus ganglion. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 15.0), placenta adult (RPKM 10.3) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
X F3; X 72.38 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (154045439..154080650)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (155262443..155297654)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene spermidine/spermine N1-acetyl transferase 1 Neighboring gene ribosomal protein L7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48136 Neighboring gene peroxiredoxin 4 Neighboring gene predicted gene, 39545 Neighboring gene predicted gene, 57670

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria. Tillander V, et al. Cell Mol Life Sci, 2014 Mar. PMID 23864032
  2. Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles. Bekeova C, et al. J Biol Chem, 2019 Dec 13. PMID 31676684, Free PMC Article
  3. Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase. Poupon V, et al. J Biol Chem, 1999 Jul 2. PMID 10383425
  4. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. Hunt MC, et al. J Lipid Res, 2005 Sep. PMID 16103133
  5. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, et al. EMBO J, 2011 Sep 23. PMID 21946561, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria.
    Title: Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in short-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
acyl-coenzyme A thioesterase 9, mitochondrial
Names
acyl coenzyme A thioester hydrolase 2
acyl-CoA thioester hydrolase 9
acyl-Coenzyme A thioesterase 2, mitochondrial
mitochondrial 48 kDa acyl-CoA thioester hydrolase 1
mitochondrial acyl-CoA thioesterase
protein U8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313718.1 → NP_001300647.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' end, which causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI854821, AK076513, BY288219
    Conserved Domains (1) summary
    PLN02647
    Location:3 → 336
    PLN02647; acyl-CoA thioesterase

  2. NM_019736.4 → NP_062710.2  acyl-coenzyme A thioesterase 9, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_062710.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI854821, AK168713, BY288219
    Consensus CDS
    CCDS41187.1
    UniProtKB/Swiss-Prot
    Q545G7, Q9R0X4, Q9WTJ0, Q9WUZ8
    Related
    ENSMUSP00000026324.10, ENSMUST00000026324.10
    Conserved Domains (1) summary
    cd03442
    Location:286 → 406
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    154045439..154080650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251411.2 → XP_030107271.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform X1

    Conserved Domains (1) summary
    PLN02647
    Location:3 → 336
    PLN02647; acyl-CoA thioesterase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0X4.1 GenPept UniProtKB/Swiss-Prot:Q9R0X4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous