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Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 [ Mus musculus (house mouse) ]

Gene ID: 56354, updated on 3-Apr-2024

Summary

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Official Symbol
Dnajc7provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C7provided by MGI
Primary source
MGI:MGI:1928373
See related
Ensembl:ENSMUSG00000014195 AllianceGenome:MGI:1928373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCRP; Ttc2; mDj11; mTpr2; 2010003F24Rik; 2010004G07Rik
Summary
Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 43.0), CNS E14 (RPKM 34.9) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Dnajc7 in Genome Data Viewer
Location:
11 D; 11 63.47 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100473644..100511030, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100582818..100620292, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5277 Neighboring gene outer dynein arm complex subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E8995 Neighboring gene STARR-positive B cell enhancer ABC_E7060 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100443371-100443554 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene STARR-positive B cell enhancer ABC_E4000 Neighboring gene STARR-positive B cell enhancer ABC_E7061 Neighboring gene STARR-positive B cell enhancer ABC_E2369 Neighboring gene STARR-positive B cell enhancer ABC_E7062 Neighboring gene NFKB inhibitor interacting Ras-like protein 2 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 11 C17orf113 homolog Neighboring gene predicted gene, 38483 Neighboring gene DExH-box helicase 58

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation. Hou Z, et al. Nat Commun, 2021 Sep 9. PMID 34504072, Free PMC Article
  2. Co-Chaperone-Mediated Suppression of LPS-Induced Cardiac Toxicity Through NFκB Signaling. Ohno M, et al. Shock, 2018 Aug. PMID 30010631
  3. Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. Squires EJ, et al. J Biol Chem, 2004 Nov 19. PMID 15347657
  4. The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers. Ohno M, et al. PLoS One, 2014. PMID 25542016, Free PMC Article
  5. Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system. Timsit YE, et al. PLoS One, 2014. PMID 24789201, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation.
    Title: DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation.
  2. present study characterized a novel physiological role of CCRP in protecting cardiac functions through the inhibition of NFkappaB signaling.
    Title: Co-Chaperone-Mediated Suppression of LPS-Induced Cardiac Toxicity Through NFκB Signaling.
  3. In CCRP knockout (KO) mice CCRP regulates CAR at multiple steps in activation of the cytochrome 2b10 gene in liver: nuclear accumulation, RNA polymerase II recruitment and epigenetic modifications.
    Title: The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers.
  4. ubiquitin-proteasomal regulation of CCRP and HSP70 are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers
    Title: Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system.
  5. cytoplasmic constitutive active/androstane receptor retention protein mediates the retention of PXR in the cytosol and modulates the activation of PXR in response to Pregnenolone Carbonitrile treatment
    Title: Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 7
Names
DnaJ (Hsp40) homolog, subfamily C, member 7
TPR repeat protein 2
cytoplasmic CAR retention protein
tetratricopeptide repeat domain 2
tetratricopeptide repeat protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378962.1 → NP_001365891.1  dnaJ homolog subfamily C member 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591469, BX842667
    UniProtKB/TrEMBL
    A0A6I8MX00, A2A5E1
    Related
    ENSMUSP00000115438.3, ENSMUST00000146840.3
    Conserved Domains (4) summary
    PLN03088
    Location:237 → 337
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    COG0484
    Location:364 → 453
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    TIGR00990
    Location:8 → 337
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:241 → 268
    TPR; TPR repeat [structural motif]

  2. NM_001378963.1 → NP_001365892.1  dnaJ homolog subfamily C member 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL591469
    UniProtKB/TrEMBL
    A0A6I8MWW2, A0A6I8MX31
    Related
    ENSMUSP00000159367.2, ENSMUST00000154972.9
    Conserved Domains (2) summary
    TIGR00990
    Location:19 → 136
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:28 → 56
    TPR; TPR repeat [structural motif]

  3. NM_001403603.1 → NP_001390532.1  dnaJ homolog subfamily C member 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591469, BX842667
    UniProtKB/Swiss-Prot
    Q3TKR1, Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026, Q9QYI3
    Related
    ENSMUSP00000159311.2, ENSMUST00000239410.2

  4. NM_019795.5 → NP_062769.2  dnaJ homolog subfamily C member 7 isoform 1

    See identical proteins and their annotated locations for NP_062769.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL591469, BX842667
    Consensus CDS
    CCDS25428.1
    UniProtKB/Swiss-Prot
    Q3TKR1, Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026, Q9QYI3
    UniProtKB/TrEMBL
    Q3UL32
    Related
    ENSMUSP00000014339.9, ENSMUST00000014339.15
    Conserved Domains (7) summary
    smart00028
    Location:28 → 61
    TPR; Tetratricopeptide repeats
    COG0484
    Location:380 → 469
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:257 → 284
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:381 → 448
    DnaJ; DnaJ domain
    pfam00515
    Location:294 → 327
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:27 → 92
    TPR_11; TPR repeat
    pfam13431
    Location:50 → 82
    TPR_17; Tetratricopeptide repeat

RNA

  1. NR_166203.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591469, BX842667
    Related
    ENSMUST00000239418.2

  2. NR_166204.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591469, BX842667
    Related
    ENSMUST00000239499.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100473644..100511030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156865.1 → XP_036012758.1  dnaJ homolog subfamily C member 7 isoform X2

    Conserved Domains (2) summary
    TIGR00990
    Location:104 → 221
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:113 → 141
    TPR; TPR repeat [structural motif]

RNA

  1. XR_001780034.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYI3.2 GenPept UniProtKB/Swiss-Prot:Q9QYI3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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