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Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 [ Mus musculus (house mouse) ]

Gene ID: 56323, updated on 16-Apr-2024

Summary

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Official Symbol
Dnajb5provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member B5provided by MGI
Primary source
MGI:MGI:1930018
See related
Ensembl:ENSMUSG00000036052 AllianceGenome:MGI:1930018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hsc40; Hsp40-3; 1110058L06Rik
Summary
Predicted to enable chaperone binding activity and unfolded protein binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in several structures, including nervous system; olfactory epithelium; retina; skeletal musculature; and tongue. Orthologous to human DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 18.7), cortex adult (RPKM 13.6) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A5; 4 22.93 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (42949866..42959425)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (42949867..42959425)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930578G10 gene Neighboring gene spermatogenesis associated 31 subfamily F member 3 Neighboring gene PHD finger protein 24 Neighboring gene predicted gene, 52697 Neighboring gene STARR-positive B cell enhancer ABC_E660 Neighboring gene SPATA31 subfamily G member 1 Neighboring gene STARR-seq mESC enhancer starr_10043 Neighboring gene STARR-positive B cell enhancer ABC_E46 Neighboring gene valosin containing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells. Chen MS, et al. Gene, 1999 Oct 1. PMID 10570961
  2. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Ago T, et al. Cell, 2008 Jun 13. PMID 18555775
  3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Ohtsuka K, et al. Cell Stress Chaperones, 2000 Apr. PMID 11147971, Free PMC Article
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dnaJ homolog subfamily B member 5
Names
DnaJ (Hsp40) homolog, subfamily B, member 5
heat shock protein cognate 40
heat shock protein hsp40-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355438.2 → NP_001342367.1  dnaJ homolog subfamily B member 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672276
    UniProtKB/TrEMBL
    Q3TYL4
    Conserved Domains (1) summary
    COG0484
    Location:72 → 415
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  2. NM_001355439.2 → NP_001342368.1  dnaJ homolog subfamily B member 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672276
    Consensus CDS
    CCDS89731.1
    UniProtKB/TrEMBL
    A2AG30, Q3TYL4
    Conserved Domains (1) summary
    COG0484
    Location:34 → 377
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  3. NM_001355440.1 → NP_001342369.1  dnaJ homolog subfamily B member 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK158972, BQ177080
    Consensus CDS
    CCDS18084.1
    UniProtKB/Swiss-Prot
    O89114
    UniProtKB/TrEMBL
    Q3TY13, Q3TYL4
    Related
    ENSMUSP00000081712.6, ENSMUST00000084662.12
    Conserved Domains (1) summary
    COG0484
    Location:1 → 343
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  4. NM_001374167.1 → NP_001361096.1  dnaJ homolog subfamily B member 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK158535, AK158972, BQ177080, BY233748
    Consensus CDS
    CCDS18084.1
    UniProtKB/Swiss-Prot
    O89114
    UniProtKB/TrEMBL
    Q3TY13, Q3TYL4
    Conserved Domains (1) summary
    COG0484
    Location:1 → 343
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  5. NM_001374168.1 → NP_001361097.1  dnaJ homolog subfamily B member 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK158535, AK158972, BQ177080
    Consensus CDS
    CCDS18084.1
    UniProtKB/Swiss-Prot
    O89114
    UniProtKB/TrEMBL
    Q3TY13, Q3TYL4
    Related
    ENSMUSP00000095716.3, ENSMUST00000098112.9
    Conserved Domains (1) summary
    COG0484
    Location:1 → 343
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  6. NM_001374169.1 → NP_001361098.1  dnaJ homolog subfamily B member 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK158535, AK158972, BQ177080, CX235957
    UniProtKB/TrEMBL
    A2AG30, Q3TYL4
    Related
    ENSMUSP00000040451.4, ENSMUST00000037872.10
    Conserved Domains (1) summary
    COG0484
    Location:34 → 377
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    42949866..42959425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164265.1 → XP_036020158.1  dnaJ homolog subfamily B member 5 isoform X1

    Conserved Domains (1) summary
    cd10747
    Location:41 → 205
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

  2. XM_036164264.1 → XP_036020157.1  dnaJ homolog subfamily B member 5 isoform X1

    Conserved Domains (1) summary
    cd10747
    Location:41 → 205
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

  3. XM_036164259.1 → XP_036020152.1  dnaJ homolog subfamily B member 5 isoform X1

    Conserved Domains (1) summary
    cd10747
    Location:41 → 205
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

  4. XM_036164260.1 → XP_036020153.1  dnaJ homolog subfamily B member 5 isoform X1

    Conserved Domains (1) summary
    cd10747
    Location:41 → 205
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

  5. XM_036164263.1 → XP_036020156.1  dnaJ homolog subfamily B member 5 isoform X1

    Conserved Domains (1) summary
    cd10747
    Location:41 → 205
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

  6. XM_036164261.1 → XP_036020154.1  dnaJ homolog subfamily B member 5 isoform X1

    Conserved Domains (1) summary
    cd10747
    Location:41 → 205
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

  7. XM_036164262.1 → XP_036020155.1  dnaJ homolog subfamily B member 5 isoform X1

    Conserved Domains (1) summary
    cd10747
    Location:41 → 205
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019874.3: Suppressed sequence

    Description
    NM_019874.3: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89114.1 GenPept UniProtKB/Swiss-Prot:O89114

Gene LinkOut

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