Dbn1 drebrin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dbn1provided by MGI
Official Full Name: drebrin 1provided by MGI
Primary source: MGI:MGI:1931838
See related: Ensembl:ENSMUSG00000034675 AllianceGenome:MGI:1931838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable actin filament binding activity; cytoskeletal motor inhibitor activity; and profilin binding activity. Involved in positive regulation of dendritic spine morphogenesis; positive regulation of receptor localization to synapse; and positive regulation of synaptic plasticity. Acts upstream of or within several processes, including cell communication by chemical coupling; cell communication by electrical coupling; and maintenance of protein location in cell. Located in several cellular components, including gap junction; glutamatergic synapse; and postsynaptic density. Is active in postsynaptic cytosol and postsynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and retina. Orthologous to human DBN1 (drebrin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 193.5), CNS E14 (RPKM 184.8) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 30.06 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (55621241..55635874, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (55473428..55488126, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drebrin is Required for Myosin-facilitated Actin Cytoskeletal Remodeling during Pulmonary Alveolar Development.
Title: Drebrin is Required for Myosin-facilitated Actin Cytoskeletal Remodeling during Pulmonary Alveolar Development.
A lack of drebrin causes olfactory impairment.
Title: A lack of drebrin causes olfactory impairment.
Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons.
Title: Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons.
The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex.
Title: The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex.
Drebrin regulates cytoskeleton dynamics in migrating neurons through interaction with CXCR4.
Title: Drebrin regulates cytoskeleton dynamics in migrating neurons through interaction with CXCR4.
Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking.
Title: Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking.
Drebrin is induced during myofibroblast differentiation and enhances the production of fibrosis-related genes.
Title: Drebrin is induced during myofibroblast differentiation and enhances the production of fibrosis-related genes.
versus micropinocytosis activities. Taken together, these findings now reveal that Dbn1 plays a major role in coordinating the actin cytoskeletal activities responsible for antigen presentation in DC.
Title: Drebrin 1 in dendritic cells regulates phagocytosis and cell surface receptor expression through recycling for efficient antigen presentation.
neuronal drebrin A directly interacts with mDia2 formin.
Title: Neuronal drebrin A directly interacts with mDia2 formin to inhibit actin assembly.
An excess of reactive oxygen species stimulates ATM-dependent phosphorylation of DBN at serine-647, which enhances protein stability and accounts for improved stress resilience in dendritic spines.
Title: ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (11) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW550627 (e-PCR)
- UniSTS:208933

Dbn1 (e-PCR), detects polymorphism
- UniSTS:239027

Dbn1 (e-PCR), detects polymorphism
- UniSTS:239028

Dbn1 (e-PCR), detects polymorphism
- UniSTS:239029

UniSTS:237020 (e-PCR)
- UniSTS:237020

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal motor inhibitor activity	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables profilin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell communication by chemical coupling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell communication by electrical coupling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic sequestering of protein	ISO Inferred from Sequence Orthology more info
involved_in generation of neurons	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of protein location in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle filament sliding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neural precursor cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axon extension	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in prepulse inhibition	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic density protein 95 clustering	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with actin filament	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with actin filament	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in asymmetric synapse	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in axonal spine	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic filopodium	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IC Inferred by Curator more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron spine	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in site of polarized growth	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: drebrin

Names: developmentally-regulated brain protein; drebrin A; drebrin E2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177371.2 → NP_001170842.1 drebrin isoform 1

See identical proteins and their annotated locations for NP_001170842.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

CT009762

Consensus CDS

CCDS49274.1

UniProtKB/Swiss-Prot

A2CG16, Q3V234, Q922X1, Q9QXS5, Q9QXS6

Related

ENSMUSP00000021950.9, ENSMUST00000021950.15

Conserved Domains (1) summary

cd11281
Location:4 → 139

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
NM_001177372.2 → NP_001170843.1 drebrin isoform 2

See identical proteins and their annotated locations for NP_001170843.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (2) differs in two regions, compared to isoform 1.

Source sequence(s)

CT009762

Consensus CDS

CCDS49273.1

UniProtKB/TrEMBL

A0A0R4J1E3

Related

ENSMUSP00000105547.3, ENSMUST00000109921.9

Conserved Domains (1) summary

cd11281
Location:4 → 139

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
NM_001426676.1 → NP_001413605.1 drebrin isoform 4

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426677.1 → NP_001413606.1 drebrin isoform 5

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426678.1 → NP_001413607.1 drebrin isoform 6

Status: VALIDATED

Source sequence(s)

CT009762

UniProtKB/Swiss-Prot

A2CG16, Q3V234, Q922X1, Q9QXS5, Q9QXS6
NM_001426679.1 → NP_001413608.1 drebrin isoform 7

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426680.1 → NP_001413609.1 drebrin isoform 8

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426681.1 → NP_001413610.1 drebrin isoform 9

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426682.1 → NP_001413611.1 drebrin isoform 10

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426683.1 → NP_001413612.1 drebrin isoform 11

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426684.1 → NP_001413613.1 drebrin isoform 12

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426685.1 → NP_001413614.1 drebrin isoform 13

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426686.1 → NP_001413615.1 drebrin isoform 14

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426687.1 → NP_001413616.1 drebrin isoform 15

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426688.1 → NP_001413617.1 drebrin isoform 16

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426689.1 → NP_001413618.1 drebrin isoform 17

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426690.1 → NP_001413619.1 drebrin isoform 18

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426691.1 → NP_001413620.1 drebrin isoform 19

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426692.1 → NP_001413621.1 drebrin isoform 20

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426693.1 → NP_001413622.1 drebrin isoform 21

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426694.1 → NP_001413623.1 drebrin isoform 22

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426695.1 → NP_001413624.1 drebrin isoform 23

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426696.1 → NP_001413625.1 drebrin isoform 24

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426697.1 → NP_001413626.1 drebrin isoform 25

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426698.1 → NP_001413627.1 drebrin isoform 26

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426699.1 → NP_001413628.1 drebrin isoform 27

Status: VALIDATED

Source sequence(s)

CT009762
NM_001426700.1 → NP_001413629.1 drebrin isoform 28

Status: VALIDATED

Source sequence(s)

CT009762
NM_019813.5 → NP_062787.2 drebrin isoform 3

See identical proteins and their annotated locations for NP_062787.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) lacks an alternate segment, compared to isoform 1.

Source sequence(s)

CT009762

Consensus CDS

CCDS36677.1

UniProtKB/TrEMBL

Q3TRK3

Related

ENSMUSP00000105549.3, ENSMUST00000109923.9

Conserved Domains (1) summary

cd11281
Location:4 → 139

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)