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Anapc7 anaphase promoting complex subunit 7 [ Mus musculus (house mouse) ]

Gene ID: 56317, updated on 21-Apr-2024

Summary

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Official Symbol
Anapc7provided by MGI
Official Full Name
anaphase promoting complex subunit 7provided by MGI
Primary source
MGI:MGI:1929711
See related
Ensembl:ENSMUSG00000029466 AllianceGenome:MGI:1929711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APC7
Summary
Predicted to enable protein phosphatase binding activity. Predicted to be involved in cell division; cellular protein metabolic process; and regulation of mitotic sister chromatid separation. Predicted to be located in nucleus and spindle. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Is expressed in embryo; genitourinary system; and metanephros. Orthologous to human ANAPC7 (anaphase promoting complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 22.5), adrenal adult (RPKM 18.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 62.36 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122559646..122582978)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122422444..122444912)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14283 Neighboring gene GPN-loop GTPase 3 Neighboring gene predicted gene, 32853 Neighboring gene STARR-positive B cell enhancer ABC_E4787 Neighboring gene STARR-positive B cell enhancer ABC_E8077 Neighboring gene actin related protein 2/3 complex, subunit 3 Neighboring gene STARR-seq mESC enhancer starr_14286 Neighboring gene ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Neighboring gene STARR-positive B cell enhancer ABC_E10346 Neighboring gene STARR-seq mESC enhancer starr_14288 Neighboring gene predicted gene, 22965

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new autoantigen reactive with prediabetic nonobese diabetic mice sera. Kang Y, et al. Mol Cells, 1999 Aug 31. PMID 10515598
  2. Cell cycle adaptations of embryonic stem cells. Ballabeni A, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22084091, Free PMC Article
  3. Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation. Nagamori I, et al. J Biol Chem, 2006 Jun 2. PMID 16595651
  4. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. Gmachl M, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922056, Free PMC Article
  5. Temporal and spatial transcriptional programs in murine kidney development. Challen G, et al. Physiol Genomics, 2005 Oct 17. PMID 15998744

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain.
    Title: APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 7
Names
cyclosome subunit 7
prediabetic NOD sera-reactive autoantigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019805.5 → NP_062779.3  anaphase-promoting complex subunit 7

    See identical proteins and their annotated locations for NP_062779.3

    Status: VALIDATED

    Source sequence(s)
    AC113285
    Consensus CDS
    CCDS19649.1
    UniProtKB/Swiss-Prot
    Q3UBM7, Q8BSR2, Q91W13, Q9WVM3
    UniProtKB/TrEMBL
    D3YU58
    Related
    ENSMUSP00000031422.4, ENSMUST00000031422.10
    Conserved Domains (2) summary
    TIGR02917
    Location:145 → 535
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:338 → 368
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122559646..122582978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165328.1 → XP_036021221.1  anaphase-promoting complex subunit 7 isoform X1

    UniProtKB/Swiss-Prot
    Q3UBM7, Q8BSR2, Q91W13, Q9WVM3
    UniProtKB/TrEMBL
    D3YU58
    Conserved Domains (2) summary
    TIGR02917
    Location:145 → 535
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:338 → 368
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVM3.3 GenPept UniProtKB/Swiss-Prot:Q9WVM3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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