Gps2 G protein pathway suppressor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gps2provided by MGI
Official Full Name: G protein pathway suppressor 2provided by MGI
Primary source: MGI:MGI:1891751
See related: Ensembl:ENSMUSG00000023170 AllianceGenome:MGI:1891751
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPS-2
Summary: Enables transcription coactivator activity and transcription corepressor activity. Involved in several processes, including negative regulation of protein K63-linked ubiquitination; regulation of signal transduction; and regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. Part of transcription repressor complex. Orthologous to human GPS2 (G protein pathway suppressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 94.4), liver E14.5 (RPKM 85.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.92 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69804805..69807882)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69913980..69917056)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity.
Title: GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity.
Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4.
Title: Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4.
Adipocyte Reprogramming by the Transcriptional Coregulator GPS2 Impacts Beta Cell Insulin Secretion.
Title: Adipocyte Reprogramming by the Transcriptional Coregulator GPS2 Impacts Beta Cell Insulin Secretion.
The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages.
Title: The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages.
GPS2 promotes erythroid differentiation by control of the stability of EKLF protein.
Title: GPS2 promotes erythroid differentiation by control of the stability of EKLF protein.
GPS2 enhances BK channel activity and its protein expression by reducing ERK1/2 signaling-mediated degradation of the channel.
Title: G protein pathway suppressor 2 enhanced the renal large-conductance Ca(2+)-activated potassium channel expression via inhibiting ERK1/2 signaling pathway.
Study in GPS2 knockout mice reveals that GPS2 in hepatocytes functionally cooperates with NCOR but not with SMRT to repress PPAR-alpha. These data collectively suggest that GPS2 promotes the progression of fatty liver disease as an epigenome modifier and PPAR-alpha-selective corepressor in hepatocytes.
Title: Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.
These findings, together, reveal an additional layer of regulation of mitochondrial gene transcription, uncover a direct mitochondria-nuclear communication pathway, and indicate that GPS2 retrograde signaling is a key component of the mitochondrial stress response in mammals.
Title: Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation.
In macrophage-specific Gps2-knockout mice, inappropriate co-repressor complex function caused enhancer activation, pro-inflammatory gene expression and hypersensitivity toward metabolic-stress signals. By contrast, transplantation of GPS2-overexpressing bone marrow into two mouse models of obesity (ob/ob and diet-induced obesity) reduced inflammation and improved insulin sensitivity.
Title: Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.
GPS2 is required for restricting the activation of TLR and BCR signaling pathways and the AKT/FOXO1 pathway in immune cells based on direct inhibition of Ubc13 enzymatic activity
Title: Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI505953 (e-PCR)
- UniSTS:180235

RH126545 (e-PCR)
- UniSTS:142225

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein K63-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein K63-linked ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to mitochondrial depolarisation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G protein pathway suppressor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357906.2 → NP_001344835.1 G protein pathway suppressor 2

Status: VALIDATED

Source sequence(s)

AL596185, AW046264, BC138880

Consensus CDS

CCDS24922.1

UniProtKB/Swiss-Prot

Q921N8

UniProtKB/TrEMBL

Q9WV81

Related

ENSMUSP00000112062.2, ENSMUST00000116358.8

Conserved Domains (1) summary

pfam15991
Location:5 → 292

G_path_suppress; G-protein pathway suppressor
NM_019726.5 → NP_062700.2 G protein pathway suppressor 2

See identical proteins and their annotated locations for NP_062700.2

Status: VALIDATED

Source sequence(s)

AL596185, AW046264, BC138880, CJ092297

Consensus CDS

CCDS24922.1

UniProtKB/Swiss-Prot

Q921N8

UniProtKB/TrEMBL

Q9WV81

Related

ENSMUSP00000054072.6, ENSMUST00000057884.6

Conserved Domains (1) summary

pfam15991
Location:5 → 292

G_path_suppress; G-protein pathway suppressor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69804805..69807882

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246187.2 → XP_030102047.1 G protein pathway suppressor 2 isoform X1

Conserved Domains (1) summary

pfam15991
Location:5 → 292

G_path_suppress; G-protein pathway suppressor