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Metap2 methionine aminopeptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 56307, updated on 5-Mar-2024

Summary

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Official Symbol
Metap2provided by MGI
Official Full Name
methionine aminopeptidase 2provided by MGI
Primary source
MGI:MGI:1929701
See related
Ensembl:ENSMUSG00000036112 AllianceGenome:MGI:1929701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p67; Amp2; Mnpep; p67eIF2; 4930584B20Rik; A930035J23Rik
Summary
Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in N-terminal protein amino acid modification; peptidyl-methionine modification; and protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol and plasma membrane. Is expressed in brain and telencephalon. Orthologous to human METAP2 (methionyl aminopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 47.5), liver E14.5 (RPKM 37.1) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C2; 10 48.69 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93694351..93732952, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93858489..93897090, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_27591 Neighboring gene STARR-positive B cell enhancer mm9_chr10:93281373-93281673 Neighboring gene STARR-seq mESC enhancer starr_27592 Neighboring gene predicted gene, 26239 Neighboring gene STARR-seq mESC enhancer starr_27593 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93352494-93352603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93401444-93401825 Neighboring gene STARR-seq mESC enhancer starr_27594 Neighboring gene microRNA 331 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene mitochondrial inner membrane protease subunit 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis. Esa R, et al. Int J Mol Sci, 2020 Jul 21. PMID 32708166, Free PMC Article
  2. 24-hour oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins. Nakagawa H, et al. Cancer Res, 2004 Nov 15. PMID 15548701
  3. Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition. Warder SE, et al. J Proteome Res, 2008 Nov. PMID 18828628
  4. Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation. Tucker LA, et al. Oncogene, 2008 Jun 26. PMID 18264137
  5. Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein (p67). Wu S, et al. J Biol Chem, 1993 May 25. PMID 8496145

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of p67(phox) in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3.
    Title: Upregulation of p67(phox) in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3.
  2. The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis.
    Title: The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis.
  3. MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity.
    Title: MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity.
  4. Discovery, identification, and characterization of candidate pharmacodynamic markers of Metap2 inhibition are reported.
    Title: Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition.
  5. MetAP2 plays an important role in tumor cell growth and may contribute to tumorigenesis
    Title: Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation.
  6. Data suggest that methionine aminopeptidase 2 plays a role in the proliferation of fibroblasts and myofibroblasts in fibrotic lung diseases and may serve as a novel pharmacologic target in idiopathic pulmonary fibrosis.
    Title: Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis.
  7. the functional role of S100A4 in regulating endothelial cell growth and tumor metastasis involves interaction with the N-terminal half of Methionine Aminopeptidase 2.
    Title: Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4.
  8. activity is regulated by the transcription of clock genes within the clock feedback loops
    Title: 24-hour oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins.
  9. The stability of p67 increases during myotube formation while inhibiting the phosphorylation of ERKs 1 and 2.
    Title: The stability of eukaryotic initiation factor 2-associated glycoprotein, p67, increases during skeletal muscle differentiation and that inhibits the phosphorylation of extracellular signal-regulated kinases 1 and 2.
  10. demonstrate an essential role for MetAP-2 in angiogenesis and indicate that MetAP-2 is responsible for the endothelial cell growth arrest induced by fumagillin and its derivatives
    Title: Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102452

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables initiator methionyl aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloexopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloexopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-terminal protein amino acid modification ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-methionine modification ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methionine aminopeptidase 2
Names
MAP 2
eIF-2-associated p67
initiation factor 2-associated 67 kDa glycoprotein
initiation factor 2-associated protein (p67)
metAP 2
peptidase M 2
NP_062622.1
XP_006513959.1
XP_006513960.1
XP_017169521.1
XP_036011787.1
XP_036011788.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019648.3 → NP_062622.1  methionine aminopeptidase 2

    See identical proteins and their annotated locations for NP_062622.1

    Status: VALIDATED

    Source sequence(s)
    AC124686, AF434712, AK165301
    Consensus CDS
    CCDS48673.1
    UniProtKB/Swiss-Prot
    O08663
    UniProtKB/TrEMBL
    Q3UI33, Q58E65
    Related
    ENSMUSP00000138006.2, ENSMUST00000180840.8
    Conserved Domains (1) summary
    PTZ00053
    Location:107 → 478
    PTZ00053; methionine aminopeptidase 2; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    93694351..93732952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513896.4 → XP_006513959.1  methionine aminopeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006513959.1

    UniProtKB/Swiss-Prot
    O08663
    UniProtKB/TrEMBL
    Q3UI33, Q58E65
    Conserved Domains (1) summary
    PTZ00053
    Location:107 → 478
    PTZ00053; methionine aminopeptidase 2; Provisional

  2. XM_017314032.2 → XP_017169521.1  methionine aminopeptidase 2 isoform X2

    UniProtKB/TrEMBL
    Q3UI33
    Conserved Domains (1) summary
    PTZ00053
    Location:106 → 477
    PTZ00053; methionine aminopeptidase 2; Provisional

  3. XM_006513897.5 → XP_006513960.1  methionine aminopeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006513960.1

    UniProtKB/Swiss-Prot
    O08663
    UniProtKB/TrEMBL
    Q3UI33, Q58E65
    Related
    ENSMUSP00000138083.2, ENSMUST00000181217.8
    Conserved Domains (1) summary
    PTZ00053
    Location:107 → 478
    PTZ00053; methionine aminopeptidase 2; Provisional

  4. XM_036155894.1 → XP_036011787.1  methionine aminopeptidase 2 isoform X1

    UniProtKB/Swiss-Prot
    O08663
    UniProtKB/TrEMBL
    Q3UI33, Q58E65
    Conserved Domains (1) summary
    PTZ00053
    Location:107 → 478
    PTZ00053; methionine aminopeptidase 2; Provisional

  5. XM_036155895.1 → XP_036011788.1  methionine aminopeptidase 2 isoform X2

    UniProtKB/TrEMBL
    Q3UI33
    Conserved Domains (1) summary
    PTZ00053
    Location:106 → 477
    PTZ00053; methionine aminopeptidase 2; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08663.1 GenPept UniProtKB/Swiss-Prot:O08663

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