Fkbpl FK506 binding protein-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fkbplprovided by MGI
Official Full Name: FK506 binding protein-likeprovided by MGI
Primary source: MGI:MGI:1932127
See related: Ensembl:ENSMUSG00000033739 AllianceGenome:MGI:1932127
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NG7; DIR1; Wisp39; Ppiase-X
Summary: Acts upstream of or within regulation of blood vessel branching. Predicted to be located in extracellular region. Is expressed in several structures, including eye; gut; hemolymphoid system; male reproductive gland or organ; and nervous system. Orthologous to human FKBPL (FKBP prolyl isomerase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 17.6), colon adult (RPKM 3.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.22 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34863788..34865791)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34644814..34646817)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FKBPL is an important regulator of developmental and pathological angiogenesis.
Title: FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis.
Results demonstrate the importance of posttranslational stabilization of p21 protein by WISp39 in regulating cellular p21 activity.
Title: Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of blood vessel branching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: FK506-binding protein-like

Names: WAF-1/CIP1 stabilizing protein 39; immunophilin-like protein NG7

NP_063926.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019873.3 → NP_063926.1 FK506-binding protein-like

See identical proteins and their annotated locations for NP_063926.1

Status: VALIDATED

Source sequence(s)

AK146018, CD776267, CT009767

Consensus CDS

CCDS28654.1

UniProtKB/Swiss-Prot

O35450, Q3UKG5

Related

ENSMUSP00000037273.9, ENSMUST00000036720.9

Conserved Domains (3) summary

COG0457
Location:203 → 316

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:208 → 236

TPR; TPR repeat [structural motif]

pfam00515
Location:285 → 317

TPR_1; Tetratricopeptide repeat