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Dmrtb1 DMRT-like family B with proline-rich C-terminal, 1 [ Mus musculus (house mouse) ]

Gene ID: 56296, updated on 11-Apr-2024

Summary

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Official Symbol
Dmrtb1provided by MGI
Official Full Name
DMRT-like family B with proline-rich C-terminal, 1provided by MGI
Primary source
MGI:MGI:1927125
See related
Ensembl:ENSMUSG00000028610 AllianceGenome:MGI:1927125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dmrt6; Prp13
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in germ cell development; regulation of transcription by RNA polymerase II; and sex differentiation. Predicted to be active in nucleus. Is expressed in brain and testis. Orthologous to human DMRTB1 (DMRT like family B with proline rich C-terminal 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 254.4) See more
Orthologs
human all
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Genomic context

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See Dmrtb1 in Genome Data Viewer
Location:
4 C7; 4 50.18 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107533485..107561208, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107676288..107704011, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene GLIS family zinc finger 1 Neighboring gene RIKEN cDNA 4930552P06 gene Neighboring gene predicted gene, 52673 Neighboring gene STARR-seq mESC enhancer starr_11025 Neighboring gene RIKEN cDNA 1700047F07 gene Neighboring gene STARR-seq mESC enhancer starr_11026 Neighboring gene predicted gene 12899 Neighboring gene predicted gene, 57502 Neighboring gene translocase of outer mitochondrial membrane 22 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis. Zhang T, et al. Development, 2014 Oct. PMID 25249458, Free PMC Article
  2. Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies. Poulain M, et al. Mol Hum Reprod, 2014 Oct. PMID 25082981
  3. The function of Dmrt genes in vertebrate development: it is not just about sex. Hong CS, et al. Dev Biol, 2007 Oct 1. PMID 17720152
  4. Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad. Kim S, et al. Gene Expr Patterns, 2003 Mar. PMID 12609607
  5. Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2. Ono K, et al. Commun Biol, 2021 Mar 11. PMID 33707608, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis.
    Title: The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables sequence-specific DNA binding IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sex differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
doublesex- and mab-3-related transcription factor B1
Names
doublesex and mab-3 related transcription factor 6
proline-rich protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019872.3 → NP_063925.1  doublesex- and mab-3-related transcription factor B1

    See identical proteins and their annotated locations for NP_063925.1

    Status: VALIDATED

    Source sequence(s)
    AL627259
    Consensus CDS
    CCDS51254.1
    UniProtKB/Swiss-Prot
    A2A9I7, Q8CGW8
    Related
    ENSMUSP00000064220.5, ENSMUST00000069271.5
    Conserved Domains (1) summary
    pfam00751
    Location:3 → 49
    DM; DM DNA binding domain

RNA

  1. NR_151717.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627259
    Related
    ENSMUST00000131776.8

  2. NR_188989.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627259

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    107533485..107561208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253681.1 → XP_030109541.1  doublesex- and mab-3-related transcription factor B1 isoform X1

    UniProtKB/Swiss-Prot
    A2A9I7, Q8CGW8
    Conserved Domains (1) summary
    pfam00751
    Location:3 → 49
    DM; DM DNA binding domain

  2. XM_036164258.1 → XP_036020151.1  doublesex- and mab-3-related transcription factor B1 isoform X2

    Conserved Domains (1) summary
    pfam00751
    Location:3 → 49
    DM; DM DNA binding domain

  3. XM_036164257.1 → XP_036020150.1  doublesex- and mab-3-related transcription factor B1 isoform X1

    UniProtKB/Swiss-Prot
    A2A9I7, Q8CGW8
    Conserved Domains (1) summary
    pfam00751
    Location:3 → 49
    DM; DM DNA binding domain

  4. XM_030253682.1 → XP_030109542.1  doublesex- and mab-3-related transcription factor B1 isoform X3

    UniProtKB/TrEMBL
    O35315
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A9I7.1 GenPept UniProtKB/Swiss-Prot:A2A9I7

Gene LinkOut

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