U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rassf1 Ras association (RalGDS/AF-6) domain family member 1 [ Mus musculus (house mouse) ]

Gene ID: 56289, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Rassf1provided by MGI
Official Full Name
Ras association (RalGDS/AF-6) domain family member 1provided by MGI
Primary source
MGI:MGI:1928386
See related
Ensembl:ENSMUSG00000010067 AllianceGenome:MGI:1928386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
123F2; RDA32; NORE2A; REH3P21; Rassf1A; Rassf1B; Rassf1C
Summary
Enables small GTPase binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; positive regulation of protein ubiquitination; and protein stabilization. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton and nucleus. Is expressed in liver and metanephros. Human ortholog(s) of this gene implicated in breast cancer; reproductive organ cancer (multiple); transitional cell carcinoma; and urinary system cancer (multiple). Orthologous to human RASSF1 (Ras association domain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 22.7), testis adult (RPKM 20.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 F1; 9 58.12 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107428752..107439460)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107551434..107562267)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10584 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E3857 Neighboring gene zinc finger, MYND domain containing 10 Neighboring gene predicted gene, 34106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107453431-107453584 Neighboring gene STARR-positive B cell enhancer ABC_E9335 Neighboring gene predicted gene 9917 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene STARR-positive B cell enhancer ABC_E2304 Neighboring gene hyaluronoglucosaminidase 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid Biopsies in Patients With Pediatric Solid Tumors. van Zogchel LMJ, et al. JCO Precis Oncol, 2021. PMID 34820594, Free PMC Article
  2. RASSF1-AS1, an antisense lncRNA of RASSF1A, inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice. Guo M, et al. Cell Biol Int, 2019 Oct. PMID 30571844
  3. RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis. Schmidt ML, et al. Cancer Res, 2018 May 15. PMID 29735543, Free PMC Article
  4. Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. Del Re DP, et al. J Clin Invest, 2010 Oct. PMID 20890045, Free PMC Article
  5. Megaoesophagus in Rassf1a-null mice. van der Weyden L, et al. Int J Exp Pathol, 2009 Apr. PMID 19335548, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RASSF1A promotes ATM signaling and RASSF1A methylation is a synthetic lethal marker for ATR inhibitors.
    Title: RASSF1A promotes ATM signaling and RASSF1A methylation is a synthetic lethal marker for ATR inhibitors.
  2. WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
    Title: WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
  3. RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.
    Title: RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.
  4. Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid Biopsies in Patients With Pediatric Solid Tumors.
    Title: Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid Biopsies in Patients With Pediatric Solid Tumors.
  5. The RASSF1A negatively regulates NF-kappaB and thereby attenuates inflammatory cytokine expression.
    Title: The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium.
  6. Findings indicate that compared with the alcoholic steatohepatitis (ASH) group of patients, the expression levels of all three tumor suppressor genes (TSGs) proteins, RUNX family transcription factor 3 (RUNX3), glutathione S-transferase pi 1 (GSTP1), and RASSF1A tumor suppressor (RASSF1), were significantly lower in the non-alcoholic steatohepatitis (NASH) group of patients.
    Title: The different expression of tumor suppressors, RASSF1A, RUNX3, and GSTP1, in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH).
  7. The authors show that an antisense lncRNA of RASSF1A inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice, indicating a potential application of RASSF1-AS1 as a therapy target for cardiac fibrosis.
    Title: RASSF1-AS1, an antisense lncRNA of RASSF1A, inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice.
  8. Study show that hypoxia promotes stabilization of RASSF1A through NOX-1- and protein kinase C- dependent phosphorylation. HIF-1alpha activates RASSF1A transcription via HIF-binding sites in the RASSF1A promoter region. RASSF1A binds to HIF-1alpha, blocks its prolyl-hydroxylation and proteasomal degradation. Study concludes that RASSF1A-HIF-1alpha forms a feedforward loop driving hypoxia signaling in pulmonary hypertens...
    Title: A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension.
  9. The authors found that haploinsufficiency of Rassf1a was sufficient to dramatically enhance the tumorigenicity of K-Ras in the system.
    Title: RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis.
  10. RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP and p73 binding to differentiation related genes.RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.
    Title: RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_negative_effect regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ras association domain-containing protein 1
Names
123F protein
RASSF1A tumor suppressor
Ras association (RalGDS/AF-6) domain family 1
protein 123F2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243748.2 → NP_001230677.1  ras association domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001230677.1

    Status: VALIDATED

    Source sequence(s)
    AL672219
    Consensus CDS
    CCDS57699.1
    UniProtKB/Swiss-Prot
    Q99MK9, Q9WUF5
    UniProtKB/TrEMBL
    A9YZW8, B0QZV7
    Related
    ENSMUSP00000091301.3, ENSMUST00000093786.9
    Conserved Domains (3) summary
    cd00029
    Location:52 → 101
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd17218
    Location:130 → 286
    RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
    pfam16517
    Location:295 → 334
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

  2. NM_001411798.1 → NP_001398727.1  ras association domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672219
    UniProtKB/TrEMBL
    Q3UIV8

  3. NM_001411799.1 → NP_001398728.1  ras association domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672219

  4. NM_001411800.1 → NP_001398729.1  ras association domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672219

  5. NM_001411801.1 → NP_001398730.1  ras association domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672219

  6. NM_019713.5 → NP_062687.1  ras association domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_062687.1

    Status: VALIDATED

    Source sequence(s)
    AL672219
    Consensus CDS
    CCDS23494.1
    UniProtKB/Swiss-Prot
    Q99MK9
    UniProtKB/TrEMBL
    Q3UIV8
    Related
    ENSMUSP00000010211.5, ENSMUST00000010211.7
    Conserved Domains (2) summary
    cd17218
    Location:60 → 216
    RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
    pfam16517
    Location:225 → 264
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107428752..107439460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MK9.1 GenPept UniProtKB/Swiss-Prot:Q99MK9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous