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Tmem45a transmembrane protein 45a [ Mus musculus (house mouse) ]

Gene ID: 56277, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem45aprovided by MGI
Official Full Name
transmembrane protein 45aprovided by MGI
Primary source
MGI:MGI:1913122
See related
Ensembl:ENSMUSG00000022754 AllianceGenome:MGI:1913122
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p19.5; C630002M10Rik
Summary
Predicted to be integral component of plasma membrane. Is expressed in forelimb and genitourinary system. Orthologous to human TMEM45A (transmembrane protein 45A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 6.4), bladder adult (RPKM 2.9) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem45a in Genome Data Viewer
Location:
16 C1.1; 16 34.22 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (56625524..56706648, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (56805161..56886433, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:56717659-56717768 Neighboring gene Trk-fused gene Neighboring gene STARR-seq mESC enhancer starr_41068 Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene predicted gene 15693 Neighboring gene STARR-seq mESC enhancer starr_41071 Neighboring gene programmed cell death 6 interacting protein pseudogene Neighboring gene leukemia NUP98 fusion partner 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation of novel complementary DNA clones from T lymphoma cells: one encodes a putative multiple membrane-spanning protein. MacLeod CL, et al. Cell Growth Differ, 1990 Jun. PMID 1980600
  2. Association of Variants in TMEM45A With Keratoglobus. Weiner C, et al. JAMA Ophthalmol, 2021 Oct 1. PMID 34410316, Free PMC Article
  3. TMEM45A Is Dispensable for Epidermal Morphogenesis, Keratinization and Barrier Formation. Hayez A, et al. PLoS One, 2016. PMID 26785122, Free PMC Article
  4. Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability. Williams TM, et al. Dev Biol, 2005 Mar 15. PMID 15733672
  5. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 45A
Names
19.5 mRNA
dermal papilla-derived protein 7 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019631.3 → NP_062605.2  transmembrane protein 45A

    See identical proteins and their annotated locations for NP_062605.2

    Status: PROVISIONAL

    Source sequence(s)
    AK049837
    Consensus CDS
    CCDS28226.1
    UniProtKB/Swiss-Prot
    Q60774
    UniProtKB/TrEMBL
    Q8BFU6
    Related
    ENSMUSP00000023435.6, ENSMUST00000023435.6
    Conserved Domains (1) summary
    pfam04819
    Location:121 → 238
    DUF716; Family of unknown function (DUF716)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    56625524..56706648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522395.5 → XP_006522458.1  transmembrane protein 45A isoform X1

    See identical proteins and their annotated locations for XP_006522458.1

    UniProtKB/Swiss-Prot
    Q60774
    Conserved Domains (1) summary
    pfam04819
    Location:121 → 238
    DUF716; Family of unknown function (DUF716)

  2. XM_030249197.2 → XP_030105057.1  transmembrane protein 45A isoform X2

    UniProtKB/Swiss-Prot
    Q60774
    UniProtKB/TrEMBL
    Q8BFU6
    Conserved Domains (1) summary
    pfam04819
    Location:121 → 238
    DUF716; Family of unknown function (DUF716)

  3. XM_006522396.4 → XP_006522459.1  transmembrane protein 45A isoform X1

    See identical proteins and their annotated locations for XP_006522459.1

    UniProtKB/Swiss-Prot
    Q60774
    Conserved Domains (1) summary
    pfam04819
    Location:121 → 238
    DUF716; Family of unknown function (DUF716)

  4. XM_036160036.1 → XP_036015929.1  transmembrane protein 45A isoform X2

    UniProtKB/Swiss-Prot
    Q60774
    UniProtKB/TrEMBL
    Q8BFU6
    Conserved Domains (1) summary
    pfam04819
    Location:121 → 238
    DUF716; Family of unknown function (DUF716)

  5. XM_036160035.1 → XP_036015928.1  transmembrane protein 45A isoform X1

    UniProtKB/Swiss-Prot
    Q60774
    Conserved Domains (1) summary
    pfam04819
    Location:121 → 238
    DUF716; Family of unknown function (DUF716)

  6. XM_030249196.2 → XP_030105056.1  transmembrane protein 45A isoform X2

    UniProtKB/Swiss-Prot
    Q60774
    UniProtKB/TrEMBL
    Q8BFU6
    Conserved Domains (1) summary
    pfam04819
    Location:121 → 238
    DUF716; Family of unknown function (DUF716)

  7. XM_017317086.2 → XP_017172575.1  transmembrane protein 45A isoform X1

    UniProtKB/Swiss-Prot
    Q60774
    Conserved Domains (1) summary
    pfam04819
    Location:121 → 238
    DUF716; Family of unknown function (DUF716)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60774.1 GenPept UniProtKB/Swiss-Prot:Q60774

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