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Actr8 ARP8 actin-related protein 8 [ Mus musculus (house mouse) ]

Gene ID: 56249, updated on 5-Mar-2024

Summary

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Official Symbol
Actr8provided by MGI
Official Full Name
ARP8 actin-related protein 8provided by MGI
Primary source
MGI:MGI:1860775
See related
Ensembl:ENSMUSG00000015971 AllianceGenome:MGI:1860775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARP8; 5730542K05Rik
Summary
Predicted to enable ATP binding activity. Predicted to be involved in double-strand break repair and regulation of transcription, DNA-templated. Predicted to act upstream of or within DNA recombination; DNA repair; and cell division. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of Ino80 complex. Is expressed in several structures, including early conceptus; liver; metanephros; and oocyte. Orthologous to human ACTR8 (actin related protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.1), CNS E14 (RPKM 10.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 18.37 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (29700294..29717409)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (29978337..29995452)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36293 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:30781255-30781364 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:30781377-30781530 Neighboring gene selenoprotein K Neighboring gene microRNA 6947 Neighboring gene interleukin 17 receptor B Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:30823404-30823587 Neighboring gene choline dehydrogenase Neighboring gene predicted gene, 35449

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evi27 encodes a novel membrane protein with homology to the IL17 receptor. Tian E, et al. Oncogene, 2000 Apr 20. PMID 10815801
  2. Coordinately Co-opted Multiple Transposable Elements Constitute an Enhancer for wnt5a Expression in the Mammalian Secondary Palate. Nishihara H, et al. PLoS Genet, 2016 Oct. PMID 27741242, Free PMC Article
  3. The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Min JN, et al. Cell Res, 2013 Dec. PMID 23979016, Free PMC Article
  4. Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. Hassel S, et al. Proteomics, 2004 May. PMID 15188402
  5. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
actin-related protein 8
Names
ARP8 actin-related protein 8 homolog
actin-related protein 8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027493.3 → NP_081769.2  actin-related protein 8

    See identical proteins and their annotated locations for NP_081769.2

    Status: VALIDATED

    Source sequence(s)
    CT009536
    Consensus CDS
    CCDS26891.1
    UniProtKB/Swiss-Prot
    Q8R2S9, Q9CYC4
    Related
    ENSMUSP00000016115.5, ENSMUST00000016115.6
    Conserved Domains (1) summary
    cl17037
    Location:160 → 619
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    29700294..29717409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247897.1 → XP_030103757.1  actin-related protein 8 isoform X2

    UniProtKB/Swiss-Prot
    Q8R2S9, Q9CYC4
    Conserved Domains (1) summary
    cl17037
    Location:160 → 619
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_006519309.4 → XP_006519372.2  actin-related protein 8 isoform X1

    Conserved Domains (1) summary
    cl17037
    Location:160 → 400
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_036158765.1 → XP_036014658.1  actin-related protein 8 isoform X3

    Conserved Domains (1) summary
    cl17037
    Location:160 → 400
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. XM_030247899.2 → XP_030103759.1  actin-related protein 8 isoform X5

    Conserved Domains (1) summary
    cl17037
    Location:5 → 368
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  5. XM_030247898.2 → XP_030103758.1  actin-related protein 8 isoform X4

    Conserved Domains (1) summary
    cl17037
    Location:5 → 150
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2S9.1 GenPept UniProtKB/Swiss-Prot:Q8R2S9

Gene LinkOut

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