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Zfp386 zinc finger protein 386 (Kruppel-like) [ Mus musculus (house mouse) ]

Gene ID: 56220, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp386provided by MGI
Official Full Name
zinc finger protein 386 (Kruppel-like)provided by MGI
Primary source
MGI:MGI:1930708
See related
Ensembl:ENSMUSG00000042063 AllianceGenome:MGI:1930708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kzf1; mKIAA4205
Summary
Enables chromatin binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; neural retina; and olfactory epithelium. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 5.0), CNS E14 (RPKM 4.4) and 25 other tissues See more
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Genomic context

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Location:
12 F2; 12 62.59 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (116011334..116026851)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (116047714..116063231)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy chain complex Neighboring gene STARR-positive B cell enhancer ABC_E923 Neighboring gene immunoglobulin heavy variable 1-85 Neighboring gene immunoglobulin heavy variable 1-86 Neighboring gene predicted gene, 53772 Neighboring gene predicted gene, 46383 Neighboring gene vasoactive intestinal peptide receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Wang L, et al. Biochem Biophys Res Commun, 2004 Dec 3. PMID 15522233
  2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • KIAA4205

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 386 (Kruppel-like)
Names
Kruppel associated box (KRAB) zinc finger 1
kruppel-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004066.3 → NP_001004066.1  zinc finger protein 386 (Kruppel-like) isoform a

    See identical proteins and their annotated locations for NP_001004066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC243430, CF723896, CJ140586
    Consensus CDS
    CCDS26209.1
    UniProtKB/TrEMBL
    Q1WWJ5
    Related
    ENSMUSP00000138305.2, ENSMUST00000183125.2
    Conserved Domains (5) summary
    smart00349
    Location:6 → 46
    KRAB; krueppel associated box
    COG5048
    Location:461 → 621
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:465 → 485
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:533 → 558
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001286214.1 → NP_001273143.1  zinc finger protein 386 (Kruppel-like) isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the coding region, which results in a reading frame shift, compared to variant 1. The resulting isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC243430, BE652367, CJ140586
    Conserved Domains (1) summary
    pfam01352
    Location:5 → 36
    KRAB; KRAB box

  3. NM_019565.4 → NP_062511.2  zinc finger protein 386 (Kruppel-like) isoform b

    See identical proteins and their annotated locations for NP_062511.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC243430, AK165544, CJ140586
    Consensus CDS
    CCDS59580.1
    UniProtKB/TrEMBL
    Q3TN43
    Related
    ENSMUSP00000073241.6, ENSMUST00000073551.6
    Conserved Domains (5) summary
    smart00349
    Location:6 → 45
    KRAB; krueppel associated box
    COG5048
    Location:426 → 586
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:430 → 450
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:498 → 523
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    116011334..116026851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157539.1 → XP_036013432.1  zinc finger protein 386 (Kruppel-like) isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:392 → 552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:396 → 416
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:352 → 377
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011244150.3 → XP_011242452.1  zinc finger protein 386 (Kruppel-like) isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:189 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:193 → 213
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:149 → 174
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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