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Acin1 apoptotic chromatin condensation inducer 1 [ Mus musculus (house mouse) ]

Gene ID: 56215, updated on 11-Apr-2024

Summary

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Official Symbol
Acin1provided by MGI
Official Full Name
apoptotic chromatin condensation inducer 1provided by MGI
Primary source
MGI:MGI:1891824
See related
Ensembl:ENSMUSG00000022185 AllianceGenome:MGI:1891824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acn; Acinus; acinusL; acinusS; mKIAA0670; 2610036I19Rik; 2610510L13Rik
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in apoptotic chromosome condensation; negative regulation of mRNA splicing, via spliceosome; and positive regulation of apoptotic process. Predicted to act upstream of or within apoptotic process. Located in nucleolus. Is expressed in several structures, including central nervous system; connective tissue; early conceptus; olfactory epithelium; and retina. Orthologous to human ACIN1 (apoptotic chromatin condensation inducer 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 53.8), CNS E14 (RPKM 33.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Acin1 in Genome Data Viewer
Location:
14 C2; 14 27.87 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54879618..54924422, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54642161..54686965, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type, 11 Neighboring gene cadherin-like 24 Neighboring gene microRNA 6948 Neighboring gene RIKEN cDNA 4930579G18 gene Neighboring gene STARR-positive B cell enhancer ABC_E1473 Neighboring gene RIKEN cDNA 1700123O20 gene Neighboring gene STARR-positive B cell enhancer ABC_E96 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene ciliated left-right organizer metallopeptidase Neighboring gene predicted gene, 53859

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Acinus-S' represses retinoic acid receptor (RAR)-regulated gene expression through interaction with the B domains of RARs. Vucetic Z, et al. Mol Cell Biol, 2008 Apr. PMID 18250153, Free PMC Article
  2. A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70. Hasegawa M, et al. Leuk Res, 2009 Aug. PMID 19058849
  3. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Sahara S, et al. Nature, 1999 Sep 9. PMID 10490026
  4. Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism. Lin YC, et al. Biochim Biophys Acta Gene Regul Mech, 2020 Sep. PMID 32629174
  5. Identification of candidate genes at the corticoseptal boundary during development. Shen WB, et al. Gene Expr Patterns, 2006 Jun. PMID 16458080

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gp70 enhances cellular DNA-damage-induced signaling in association with host-specific cellular proteins including acinus and MCM2 resulting in the activation of DNA-PK to phosphorylate P53.
    Title: A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ASAP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ASAP complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
apoptotic chromatin condensation inducer in the nucleus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085472.2 → NP_001078941.2  apoptotic chromatin condensation inducer in the nucleus isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    BC052755, BC094217, BY287113
    Consensus CDS
    CCDS49492.1
    UniProtKB/TrEMBL
    B8JJ92
    Related
    ENSMUSP00000122003.4, ENSMUST00000148754.10
    Conserved Domains (2) summary
    cd12432
    Location:253 → 339
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:407 → 482
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  2. NM_001085473.2 → NP_001078942.2  apoptotic chromatin condensation inducer in the nucleus isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the mid coding region, compared to variant 1. The resulting isoform (4) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF168782, AK011698, AK050467, AK122342, BC094217
    UniProtKB/TrEMBL
    F6RJ39
    Related
    ENSMUSP00000119080.2, ENSMUST00000147714.8
    Conserved Domains (3) summary
    smart00513
    Location:72 → 106
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd12432
    Location:998 → 1084
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:1152 → 1227
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  3. NM_001242605.1 → NP_001229534.1  apoptotic chromatin condensation inducer in the nucleus isoform 5

    See identical proteins and their annotated locations for NP_001229534.1

    Status: VALIDATED

    Description
    This variant (5) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which is associated with a strong Kozak sequence.
    Source sequence(s)
    AF124729, BC094217, BY295579
    Consensus CDS
    CCDS56957.1
    UniProtKB/TrEMBL
    B8JJ92
    Related
    ENSMUSP00000114546.2, ENSMUST00000126166.8
    Conserved Domains (2) summary
    cd12432
    Location:237 → 323
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:432 → 466
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  4. NM_001242606.1 → NP_001229535.1  apoptotic chromatin condensation inducer in the nucleus isoform 6

    See identical proteins and their annotated locations for NP_001229535.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a 5' exon and uses an alternate splice site in the coding region compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which is associated with a strong Kozak sequence.
    Source sequence(s)
    BC094217, BY295579
    Consensus CDS
    CCDS56956.1
    UniProtKB/TrEMBL
    Q52KR6
    Related
    ENSMUSP00000116664.2, ENSMUST00000141453.8
    Conserved Domains (2) summary
    cd12432
    Location:224 → 310
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:419 → 453
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  5. NM_001374770.1 → NP_001361699.1  apoptotic chromatin condensation inducer in the nucleus isoform 7

    Status: VALIDATED

    Source sequence(s)
    CT009512
    Consensus CDS
    CCDS88664.1
    UniProtKB/TrEMBL
    F6RJ39
    Related
    ENSMUSP00000107109.3, ENSMUST00000111484.9
    Conserved Domains (5) summary
    smart00513
    Location:72 → 106
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd12432
    Location:970 → 1056
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    TIGR01348
    Location:373 → 507
    PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
    pfam02463
    Location:86 → 376
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam16294
    Location:1165 → 1199
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  6. NM_019567.3 → NP_062513.3  apoptotic chromatin condensation inducer in the nucleus isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AF124725, BC094217, BY295579, BY711288
    Consensus CDS
    CCDS27098.2
    UniProtKB/TrEMBL
    B8JJ91
    Related
    ENSMUSP00000118069.2, ENSMUST00000150371.8
    Conserved Domains (2) summary
    cd12432
    Location:306 → 392
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:460 → 535
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  7. NM_023190.3 → NP_075679.2  apoptotic chromatin condensation inducer in the nucleus isoform 2

    See identical proteins and their annotated locations for NP_075679.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF168782, AK011698, AK030449, BC094217
    Consensus CDS
    CCDS27097.1
    UniProtKB/Swiss-Prot
    B8JJ87, Q9CSN7, Q9CSR9, Q9CSX7, Q9JIX8, Q9R046, Q9R047
    UniProtKB/TrEMBL
    F6RJ39
    Related
    ENSMUSP00000022793.9, ENSMUST00000022793.15
    Conserved Domains (3) summary
    smart00513
    Location:72 → 106
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd12432
    Location:1010 → 1096
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:1164 → 1239
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54879618..54924422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247893.2 → XP_030103753.1  apoptotic chromatin condensation inducer in the nucleus isoform X3

    UniProtKB/TrEMBL
    F6RJ39
    Conserved Domains (5) summary
    smart00513
    Location:72 → 106
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd12432
    Location:969 → 1055
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    TIGR01348
    Location:373 → 507
    PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
    pfam02463
    Location:86 → 376
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam16294
    Location:1164 → 1198
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  2. XM_030247894.2 → XP_030103754.1  apoptotic chromatin condensation inducer in the nucleus isoform X4

    UniProtKB/TrEMBL
    F6RJ39
    Conserved Domains (5) summary
    smart00513
    Location:72 → 106
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd12432
    Location:958 → 1044
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    TIGR01348
    Location:373 → 507
    PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
    pfam02463
    Location:86 → 376
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam16294
    Location:1153 → 1187
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  3. XM_006519297.3 → XP_006519360.1  apoptotic chromatin condensation inducer in the nucleus isoform X2

    UniProtKB/TrEMBL
    F6RJ39
    Conserved Domains (5) summary
    smart00513
    Location:72 → 106
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PTZ00121
    Location:210 → 416
    PTZ00121; MAEBL; Provisional
    cd12432
    Location:997 → 1083
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    TIGR01348
    Location:413 → 547
    PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
    pfam16294
    Location:1192 → 1226
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  4. XM_006519296.3 → XP_006519359.1  apoptotic chromatin condensation inducer in the nucleus isoform X1

    UniProtKB/TrEMBL
    F6RJ39
    Conserved Domains (5) summary
    smart00513
    Location:72 → 106
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PTZ00121
    Location:210 → 416
    PTZ00121; MAEBL; Provisional
    cd12432
    Location:1009 → 1095
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    TIGR01348
    Location:413 → 547
    PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
    pfam16294
    Location:1204 → 1238
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  5. XM_006519308.4 → XP_006519371.1  apoptotic chromatin condensation inducer in the nucleus isoform X9

    See identical proteins and their annotated locations for XP_006519371.1

    UniProtKB/TrEMBL
    Q52KR6
    Conserved Domains (2) summary
    cd12432
    Location:224 → 310
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:419 → 453
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  6. XM_006519304.4 → XP_006519367.1  apoptotic chromatin condensation inducer in the nucleus isoform X8

    See identical proteins and their annotated locations for XP_006519367.1

    UniProtKB/TrEMBL
    B8JJ92
    Conserved Domains (2) summary
    cd12432
    Location:237 → 323
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:432 → 466
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  7. XM_006519301.2 → XP_006519364.1  apoptotic chromatin condensation inducer in the nucleus isoform X5

    Conserved Domains (2) summary
    cd12432
    Location:319 → 405
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:514 → 548
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  8. XM_030247896.1 → XP_030103756.1  apoptotic chromatin condensation inducer in the nucleus isoform X7

    Conserved Domains (2) summary
    cd12432
    Location:293 → 379
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:488 → 522
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  9. XM_030247895.1 → XP_030103755.1  apoptotic chromatin condensation inducer in the nucleus isoform X6

    Conserved Domains (2) summary
    cd12432
    Location:306 → 392
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:501 → 535
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

RNA

  1. XR_004938418.1 RNA Sequence

  2. XR_003950876.2 RNA Sequence

  3. XR_003950874.2 RNA Sequence

  4. XR_004938423.1 RNA Sequence

  5. XR_003950872.2 RNA Sequence

  6. XR_003950870.2 RNA Sequence

  7. XR_004938420.1 RNA Sequence

  8. XR_004938419.1 RNA Sequence

  9. XR_003950871.2 RNA Sequence

  10. XR_004938422.1 RNA Sequence

  11. XR_004938421.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIX8.3 GenPept UniProtKB/Swiss-Prot:Q9JIX8

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