Rhog ras homolog family member G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhogprovided by MGI
Official Full Name: ras homolog family member Gprovided by MGI
Primary source: MGI:MGI:1928370
See related: Ensembl:ENSMUSG00000073982 AllianceGenome:MGI:1928370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arhg; Sid10750; 2810426G09Rik
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within regulation of ruffle assembly. Predicted to be located in membrane. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Orthologous to human RHOG (ras homolog family member G). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 80.5), thymus adult (RPKM 76.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.71 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (101888330..101899325, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (102239123..102250118, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELMO2-RhoG-ILK complex has a key role in integrin-independent stabilization of the microtubule network in differentiated keratinocytes.
Title: An ELMO2-RhoG-ILK network modulates microtubule dynamics.
RhoG protein regulates platelet granule secretion and thrombus formation in mice.
Title: RhoG protein regulates platelet granule secretion and thrombus formation in mice.
RhoG is expressed and activated in platelets, plays an important role in GPVI-Fc receptor gamma-chain complex-mediated platelet activation, and is critical for thrombus formation in vivo.
Title: RhoG protein regulates glycoprotein VI-Fc receptor γ-chain complex-mediated platelet activation and thrombus formation.
Examined the role of RhoG in the invasive behavior of glioblastoma cells; found that depletion of RhoG strongly inhibits activation of the Rac1 GTPase by both HGF and EGF; also RhoG contributes to the formation of lamellipodia and invadopodia.
Title: The small GTPase RhoG mediates glioblastoma cell invasion.
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac, CDC42, and RhoG small GTPase activities
Title: Cooperative activation of PI3K by Ras and Rho family small GTPases.
Results indicate that RhoG promotes neural progenitor cell proliferation through PI3K in cortical development.
Title: RhoG promotes neural progenitor cell proliferation in mouse cerebral cortex.
Resutls show that the interaction with ELMO2 and RhoG is essential for the ability of ILK to induce front-rear cell polarity.
Title: Integrin-linked kinase interactions with ELMO2 modulate cell polarity.
Fibroblast growth factor 2-induced Rac1 activation depends on the suppression of RhoG by a previously uncharacterized ternary S4-synectin-RhoGDI1 protein complex and activation via PKCalpha.
Title: Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.
different biological properties of RhoG and Rac1 can be traced to specific amino acid variations in their switch I, beta2/beta3 hairpin, alpha5 helix, and C-terminal polybasic regions.
Title: Structural basis for the signaling specificity of RhoG and Rac1 GTPases.
RhoG function is mediated by signals independent of Rac1 and Cdc42 activation and instead by direct utilization of a subset of common effectors
Title: RhoG signals in parallel with Rac1 and Cdc42.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ARHG_57 (e-PCR)
- UniSTS:277012

42.MMHAP90FRF12.seq (e-PCR)
- UniSTS:124476

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cortical cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of ruffle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho-related GTP-binding protein RhoG

Names: aplysia ras-related homolog G (RhoG); ras homolog G (RhoG); ras homolog gene family, member G; sid 10750

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019566.3 → NP_062512.1 rho-related GTP-binding protein RhoG

See identical proteins and their annotated locations for NP_062512.1

Status: VALIDATED

Source sequence(s)

AK143623, BQ942269

Consensus CDS

CCDS21529.1

UniProtKB/Swiss-Prot

P84096

UniProtKB/TrEMBL

Q3UDZ1

Related

ENSMUSP00000095832.5, ENSMUST00000098230.11

Conserved Domains (1) summary

cd01875
Location:1 → 191

RhoG; Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)