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Rev1 REV1, DNA directed polymerase [ Mus musculus (house mouse) ]

Gene ID: 56210, updated on 21-Apr-2024

Summary

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Official Symbol
Rev1provided by MGI
Official Full Name
REV1, DNA directed polymeraseprovided by MGI
Primary source
MGI:MGI:1929074
See related
Ensembl:ENSMUSG00000026082 AllianceGenome:MGI:1929074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rev1l; 1110027I23Rik
Summary
Enables deoxycytidyl transferase activity. Acts upstream of or within error-prone translesion synthesis. Predicted to be located in nucleus. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.2), CNS E14 (RPKM 7.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 16.46 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (38091867..38169191, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (38052786..38129921, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3269 Neighboring gene STARR-positive B cell enhancer ABC_E10006 Neighboring gene STARR-seq mESC enhancer starr_00688 Neighboring gene thioredoxin domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_00689 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene predicted gene, 34448 Neighboring gene STARR-seq mESC enhancer starr_00690 Neighboring gene STARR-seq mESC enhancer starr_00691 Neighboring gene predicted gene 5099 Neighboring gene AF4/FMR2 family, member 3 Neighboring gene predicted gene 16150

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females. In Het Panhuis W, et al. Am J Physiol Endocrinol Metab, 2022 Mar 1. PMID 35156394
  2. Rev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity. Prasad R, et al. Nucleic Acids Res, 2016 Dec 15. PMID 27683219, Free PMC Article
  3. Y-family DNA polymerase-independent gap-filling translesion synthesis across aristolochic acid-derived adenine adducts in mouse cells. Hashimoto K, et al. DNA Repair (Amst), 2016 Oct. PMID 27497692, Free PMC Article
  4. Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway. Krijger PH, et al. Eur J Immunol, 2013 Oct. PMID 23857323
  5. A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during Ig gene hypermutation. Masuda K, et al. J Immunol, 2009 Aug 1. PMID 19587019

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females.
    Title: Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females.
  2. Rev1 contributes to proper mitochondrial function via the PARP-NAD-SIRT1-PGC1A axis.
    Title: Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1α axis.
  3. These data indicate that dysregulation of cellular Rev1 levels leads to the accumulation of mutations and suppression of cell death, which accelerates the tumorigenic activities of DNA-damaging agents.
    Title: Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.
  4. Rev1 could serve as a backup polymerase in base excision repair and could potentially contribute to activation-induced cytidine deaminase-initiated antibody diversification through this activity.
    Title: Rev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity.
  5. The results support the idea that Rev1 is not essential for the cellular translesion DNA synthesis functions of DNA polymerase zeta in mammalian cells.
    Title: Y-family DNA polymerase-independent gap-filling translesion synthesis across aristolochic acid-derived adenine adducts in mouse cells.
  6. REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.
    Title: REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18.
  7. Rev1 is essential for the Msh2-independent generation of these transversions downstream of Ung2-induced apyrimidinic sites.
    Title: Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway.
  8. Rev1 operates in the same pathway as Ung, as emphasized by further decreased CSR in Rev1(-/-)Msh2(-/-) B cells.
    Title: Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.
  9. Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) zeta, and Pol kappa
    Title: Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ.
  10. REV1 and Polkappa are involved in DNA damage tolerance via Poleta-REV1 interaction when Poleta fails to bypass its cognate substrates.
    Title: Stalled Polη at its cognate substrate initiates an alternative translesion synthesis pathway via interaction with REV1.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC66950

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables deoxycytidyl transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxycytidyl transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in error-free translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within error-prone translesion synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA repair protein REV1
Names
REV1 homolog
rev1-like terminal deoxycytidyl transferase
NP_001346216.1
NP_001346217.1
NP_062516.2
XP_006496216.2
XP_006496217.2
XP_006496218.2
XP_006496219.1
XP_006496224.1
XP_006496225.1
XP_017177324.1
XP_017177325.1
XP_030111499.1
XP_030111501.1
XP_036008367.1
XP_036008368.1
XP_036008369.1
XP_036008370.1
XP_036008371.1
XP_036008372.1
XP_036008373.1
XP_036008374.1
XP_036008375.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359287.1 → NP_001346216.1  DNA repair protein REV1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114583
    Conserved Domains (3) summary
    cd01701
    Location:16 → 333
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:666 → 759
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:516 → 551
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  2. NM_001359288.1 → NP_001346217.1  DNA repair protein REV1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114583
    Conserved Domains (3) summary
    cd12145
    Location:634 → 727
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:484 → 519
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
    cl28996
    Location:1 → 301
    PolY; Y-family of DNA polymerases

  3. NM_019570.4 → NP_062516.2  DNA repair protein REV1 isoform 1

    See identical proteins and their annotated locations for NP_062516.2

    Status: VALIDATED

    Source sequence(s)
    AK048838, BC058093
    Consensus CDS
    CCDS14899.1
    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Related
    ENSMUSP00000027251.7, ENSMUST00000027251.12
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1155 → 1248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1005 → 1040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    38091867..38169191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255641.2 → XP_030111501.1  DNA repair protein REV1 isoform X3

    Conserved Domains (4) summary
    cd01701
    Location:346 → 812
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1145 → 1238
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:995 → 1030
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  2. XM_036152478.1 → XP_036008371.1  DNA repair protein REV1 isoform X2

    Conserved Domains (4) summary
    cd01701
    Location:346 → 821
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1154 → 1247
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1004 → 1039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  3. XM_006496155.5 → XP_006496218.2  DNA repair protein REV1 isoform X3

    Conserved Domains (4) summary
    cd01701
    Location:346 → 812
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1145 → 1238
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:995 → 1030
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  4. XM_036152474.1 → XP_036008367.1  DNA repair protein REV1 isoform X5

    Conserved Domains (4) summary
    cd01701
    Location:346 → 779
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1112 → 1205
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:962 → 997
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  5. XM_006496154.5 → XP_006496217.2  DNA repair protein REV1 isoform X2

    Conserved Domains (4) summary
    cd01701
    Location:346 → 821
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1154 → 1247
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1004 → 1039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  6. XM_006496153.5 → XP_006496216.2  DNA repair protein REV1 isoform X1

    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1155 → 1248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1005 → 1040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  7. XM_036152475.1 → XP_036008368.1  DNA repair protein REV1 isoform X1

    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1155 → 1248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1005 → 1040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  8. XM_036152479.1 → XP_036008372.1  DNA repair protein REV1 isoform X2

    Conserved Domains (4) summary
    cd01701
    Location:346 → 821
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1154 → 1247
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1004 → 1039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  9. XM_030255639.2 → XP_030111499.1  DNA repair protein REV1 isoform X1

    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1155 → 1248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1005 → 1040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  10. XM_006496156.4 → XP_006496219.1  DNA repair protein REV1 isoform X4

    Conserved Domains (4) summary
    cd01701
    Location:361 → 837
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1170 → 1263
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:63 → 146
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    pfam14377
    Location:948 → 969
    DUF4414; Domain of unknown function (DUF4414)

  11. XM_036152481.1 → XP_036008374.1  DNA repair protein REV1 isoform X7

    Conserved Domains (3) summary
    cd12145
    Location:634 → 727
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:484 → 519
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
    cl28996
    Location:1 → 301
    PolY; Y-family of DNA polymerases

  12. XM_036152477.1 → XP_036008370.1  DNA repair protein REV1 isoform X1

    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1155 → 1248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1005 → 1040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  13. XM_036152476.1 → XP_036008369.1  DNA repair protein REV1 isoform X1

    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1155 → 1248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1005 → 1040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  14. XM_006496161.3 → XP_006496224.1  DNA repair protein REV1 isoform X6

    Conserved Domains (3) summary
    cd01701
    Location:16 → 333
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:666 → 759
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:516 → 551
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  15. XM_017321835.2 → XP_017177324.1  DNA repair protein REV1 isoform X7

    Conserved Domains (3) summary
    cd12145
    Location:634 → 727
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:484 → 519
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
    cl28996
    Location:1 → 301
    PolY; Y-family of DNA polymerases

  16. XM_017321836.2 → XP_017177325.1  DNA repair protein REV1 isoform X6

    Conserved Domains (3) summary
    cd01701
    Location:16 → 333
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:666 → 759
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:516 → 551
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  17. XM_006496162.2 → XP_006496225.1  DNA repair protein REV1 isoform X7

    See identical proteins and their annotated locations for XP_006496225.1

    Conserved Domains (3) summary
    cd12145
    Location:634 → 727
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:484 → 519
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
    cl28996
    Location:1 → 301
    PolY; Y-family of DNA polymerases

  18. XM_036152480.1 → XP_036008373.1  DNA repair protein REV1 isoform X6

    Related
    ENSMUST00000194650.6
    Conserved Domains (3) summary
    cd01701
    Location:16 → 333
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:666 → 759
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:516 → 551
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  19. XM_036152482.1 → XP_036008375.1  DNA repair protein REV1 isoform X7

    Conserved Domains (3) summary
    cd12145
    Location:634 → 727
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:484 → 519
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
    cl28996
    Location:1 → 301
    PolY; Y-family of DNA polymerases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920Q2.1 GenPept UniProtKB/Swiss-Prot:Q920Q2

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