Gde1 glycerophosphodiester phosphodiesterase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gde1provided by MGI
Official Full Name: glycerophosphodiester phosphodiesterase 1provided by MGI
Primary source: MGI:MGI:1891827
See related: Ensembl:ENSMUSG00000033917 AllianceGenome:MGI:1891827
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mir16; RGS16; 1200003M13Rik
Summary: Enables glycerophosphodiester phosphodiesterase activity; glycerophosphoinositol glycerophosphodiesterase activity; and lysophospholipase activity. Involved in ethanolamine metabolic process. Acts upstream of or within N-acylethanolamine metabolic process and phospholipid metabolic process. Located in plasma membrane. Is expressed in several structures, including ganglia; gut; lower urinary tract; lung; and nasal cavity epithelium. Orthologous to human GDE1 (glycerophosphodiester phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 163.5), duodenum adult (RPKM 134.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 63.52 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (118287781..118304961, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (118688558..118705738, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors confirmed the role of Gde1 in NAFLD by in vivo hepatic over-expression and shRNA knockdown studies.
Title: The genetic architecture of NAFLD among inbred strains of mice.
findings designate GroPSer as a previously unappreciated reservoir for free serine in the nervous system and suggest that GDE1, through recycling serine from GroPSer, may impact D-serine-dependent neural signaling processes in vivo
Title: The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice.
Characterization of mice lacking N-acyl ethanolamine biosynthetic enzymes.
Title: Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo.
a multistep pathway for the production of anandamide in the nervous system by the sequential actions of Abh4 and GDE1.
Title: Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain.
regulation by by stimulation of G protein-coupled receptors
Title: GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycerophosphodiester phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerophosphodiester phosphodiesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycerophosphodiester phosphodiesterase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycerophosphoinositol glycerophosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerophosphoinositol glycerophosphodiesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in N-acylethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within N-acylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in N-acylethanolamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ethanolamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: glycerophosphodiester phosphodiesterase 1

Names: glycerophosphoinositol glycerophosphodiesterase GDE1; lysophospholipase D GDE1; membrane interacting protein of RGS16

NP_062526.1

EC 3.1.4.44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019580.4 → NP_062526.1 glycerophosphodiester phosphodiesterase 1

See identical proteins and their annotated locations for NP_062526.1

Status: PROVISIONAL

Source sequence(s)

AK005361

Consensus CDS

CCDS21774.1

UniProtKB/Swiss-Prot

Q3UBU4, Q9JL56

Related

ENSMUSP00000046371.9, ENSMUST00000038791.15

Conserved Domains (1) summary

cd08573
Location:68 → 323

GDPD_GDE1; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE1 and similar proteins