Becn1 beclin 1, autophagy related [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Becn1provided by MGI
Official Full Name: beclin 1, autophagy relatedprovided by MGI
Primary source: MGI:MGI:1891828
See related: Ensembl:ENSMUSG00000035086 AllianceGenome:MGI:1891828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Atg6
Summary: Enables identical protein binding activity. Involved in several processes, including autophagy of mitochondrion; cellular response to glucose starvation; and engulfment of apoptotic cell. Acts upstream of or within several processes, including amyloid-beta metabolic process; negative regulation of autophagosome assembly; and positive regulation of cardiac muscle hypertrophy. Located in autophagosome; phagocytic vesicle; and trans-Golgi network. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in central nervous system; extraembryonic visceral endoderm; sensory organ; and spleen. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 39.6), bladder adult (RPKM 35.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 64.58 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101179084..101193112, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (101288258..101302286, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Implication of the Autophagy-Related Protein Beclin1 in the Regulation of EcoHIV Replication and Inflammatory Responses.
Title: Implication of the Autophagy-Related Protein Beclin1 in the Regulation of EcoHIV Replication and Inflammatory Responses.
Autophagy core protein BECN1 is vital for spermatogenesis and male fertility in micedagger.
Title: Autophagy core protein BECN1 is vital for spermatogenesis and male fertility in mice†.
Cisplatin Nephrotoxicity Is Critically Mediated by the Availability of BECLIN1.
Title: Cisplatin Nephrotoxicity Is Critically Mediated by the Availability of BECLIN1.
BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking.
Title: BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking.
Beclin1 is essential for the pancreas development.
Title: Beclin1 is essential for the pancreas development.
Yap1-Usp14 Axis Inhibits Neuronal Mitophagy During Neonatal Hypoxia-Ischemia Encephalopathy by Regulation of Beclin-1 Ubiquitination in Mouse.
Title: Yap1-Usp14 Axis Inhibits Neuronal Mitophagy During Neonatal Hypoxia-Ischemia Encephalopathy by Regulation of Beclin-1 Ubiquitination in Mouse.
Genetically prolonged beige fat in male mice confers long-lasting metabolic health.
Title: Genetically prolonged beige fat in male mice confers long-lasting metabolic health.
Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy.
Title: Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy.
BECN1[F121A] mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner.
Title: BECN1(F121A) mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner.
Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy.
Title: Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy.

Submit: New GeneRIF Correction See all GeneRIFs (144)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (12) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH48446 (e-PCR)
- UniSTS:73245

PMC299911P1 (e-PCR)
- UniSTS:272470

RH127824 (e-PCR)
- UniSTS:211134

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amyloid-beta metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info	PubMed
involved_in autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lysosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macroautophagy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to lysosome	NAS Non-traceable Author Statement more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in response to mitochondrial depolarisation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to other organism	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
colocalizes_with mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class III	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class III, type I	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type II	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beclin-1

Names: Bcl-2-interacting protein beclin; Beclin-1; coiled-coil, myosin-like BCL2-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359819.1 → NP_001346748.1 beclin-1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK032176, AK077392, CB723507

Conserved Domains (2) summary

pfam15285
Location:20 → 42

BH3; Beclin-1 BH3 domain, Bcl-2-interacting

pfam04111
Location:48 → 358

APG6; Autophagy protein Apg6
NM_001359820.1 → NP_001346749.1 beclin-1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK032176, AK077392, CB723507

Conserved Domains (2) summary

pfam04111
Location:66 → 247

APG6; Autophagy protein Apg6

pfam17675
Location:31 → 63

APG6_N; Apg6 coiled-coil region
NM_001359821.1 → NP_001346750.1 beclin-1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 3' terminal exon and lacks several exons, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL590969

Consensus CDS

CCDS88257.1

UniProtKB/TrEMBL

E9QAM0

Related

ENSMUSP00000128413.2, ENSMUST00000170502.2
NM_019584.4 → NP_062530.2 beclin-1 isoform 1

See identical proteins and their annotated locations for NP_062530.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK032176, AK077392, CB723507

Consensus CDS

CCDS25462.1

UniProtKB/Swiss-Prot

O88597, Q99J03

Related

ENSMUSP00000119369.2, ENSMUST00000130916.8

Conserved Domains (3) summary

pfam04111
Location:133 → 444

APG6; Autophagy protein Apg6

pfam12777
Location:194 → 267

MT; Microtubule-binding stalk of dynein motor

pfam15285
Location:105 → 127

BH3; Beclin-1 BH3 domain, Bcl-2-interacting