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Plek pleckstrin [ Mus musculus (house mouse) ]

Gene ID: 56193, updated on 11-Apr-2024

Summary

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Official Symbol
Plekprovided by MGI
Official Full Name
pleckstrinprovided by MGI
Primary source
MGI:MGI:1860485
See related
Ensembl:ENSMUSG00000020120 AllianceGenome:MGI:1860485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010300B13Rik
Summary
Predicted to enable phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity. Involved in several processes, including exocytosis; platelet aggregation; and positive regulation of cellular component organization. Predicted to be located in cytoplasm and ruffle membrane. Predicted to be active in plasma membrane. Orthologous to human PLEK (pleckstrin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 8.7), liver E14.5 (RPKM 6.7) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A2; 11 9.41 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16921206..16958718, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16971206..17008718, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor receptor Neighboring gene epidermal growth factor receptor, opposite strand Neighboring gene STARR-seq mESC enhancer starr_28697 Neighboring gene STARR-seq mESC enhancer starr_28698 Neighboring gene STARR-seq mESC enhancer starr_28699 Neighboring gene STARR-seq mESC enhancer starr_28700 Neighboring gene Egfr long non-coding downstream RNA Neighboring gene F-box protein 48 Neighboring gene STARR-positive B cell enhancer ABC_E8386 Neighboring gene STARR-positive B cell enhancer ABC_E1819 Neighboring gene signal peptide, CUB domain, EGF-like 3 pseudogene Neighboring gene predicted gene, 53668

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain. Meuillet EJ. Curr Med Chem, 2011. PMID 21649580, Free PMC Article
  2. Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Lian L, et al. Blood, 2009 Apr 9. PMID 19190246, Free PMC Article
  3. cDNA cloning and mapping of mouse pleckstrin (Plek), a gene upregulated in transformation-resistant cells. Cmarik JL, et al. Genomics, 2000 Jun 1. PMID 10860665
  4. DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. Abdallah BM, et al. J Bone Miner Res, 2011 Jul. PMID 21308776
  5. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting of the pleckstrin homology domain of AKT was studied in cancer treatment in mouse models.
    Title: Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.
  2. pleckstrin regulates the fusion of granules to the cell membrane and is an essential component of PKC-mediated exocytosis in platelets
    Title: Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell projection organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet aggregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inositol-polyphosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of integrin activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of platelet activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion by platelet IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell diameter ISO
Inferred from Sequence Orthology
more info
  
involved_in ruffle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in thrombin-activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thrombin-activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking involved in exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019549.2 → NP_062422.1  pleckstrin

    See identical proteins and their annotated locations for NP_062422.1

    Status: VALIDATED

    Source sequence(s)
    AK151460, BY149522, CJ198197
    Consensus CDS
    CCDS24446.1
    UniProtKB/Swiss-Prot
    Q9ERI9, Q9JHK5
    UniProtKB/TrEMBL
    Q5F271, Q8C6F4
    Related
    ENSMUSP00000099945.4, ENSMUST00000102881.10
    Conserved Domains (4) summary
    cd04445
    Location:125 → 223
    DEP_PLEK1; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, ...
    cd13301
    Location:3 → 110
    PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1
    cd13302
    Location:239 → 346
    PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:6 → 101
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    16921206..16958718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHK5.1 GenPept UniProtKB/Swiss-Prot:Q9JHK5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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