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Prodh2 proline dehydrogenase (oxidase) 2 [ Mus musculus (house mouse) ]

Gene ID: 56189, updated on 11-Apr-2024

Summary

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Official Symbol
Prodh2provided by MGI
Official Full Name
proline dehydrogenase (oxidase) 2provided by MGI
Primary source
MGI:MGI:1929093
See related
Ensembl:ENSMUSG00000036892 AllianceGenome:MGI:1929093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
POX1; HYPDH; MmPOX; MmPOX1; 2510028N04Rik; 2510038B11Rik
Summary
Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to act upstream of or within proline metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; renal cortex; and sensory organ. Orthologous to human PRODH2 (proline dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 113.0), liver E18 (RPKM 66.3) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 18.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30193011..30212830)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30493586..30513402)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nephrosis 1, nephrin Neighboring gene nephrosis 1 homolog, nephrin, opposite strand Neighboring gene ribosomal protein S12, pseudogene 4 Neighboring gene Rho GTPase activating protein 33, opposite strand Neighboring gene Rho GTPase activating protein 33 Neighboring gene STARR-positive B cell enhancer ABC_E1731

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proline oxidase-adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation. Lettieri Barbato D, et al. Cell Death Differ, 2014 Jan. PMID 24096872, Free PMC Article
  2. The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria. Buchalski B, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Mar 1. PMID 31821850, Free PMC Article
  3. Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase. Li X, et al. Biochim Biophys Acta, 2016 Feb. PMID 26655602, Free PMC Article
  4. Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. Kamiya A, et al. FEBS Lett, 2004 Dec 3. PMID 15581617
  5. A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Maynard TM, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14614146, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreasing hepatic glycolate oxidase and HYPDH expression decreases oxalate excretion.
    Title: Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.
  2. The nutrient starvation elicits increased activity of mitochondrial proline oxidase/dehydrogenase (POX/PRODH) that is causal in triggering a ROS-dependent induction of ATGL.
    Title: Proline oxidase-adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation.
  3. study revealed that the expression of PO and PDH was regulated by HNF1alpha and HNF4alpha
    Title: Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-NH group of donors ISO
Inferred from Sequence Orthology
more info
  
enables proline dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proline catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proline catabolic process to glutamate IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proline metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hydroxyproline dehydrogenase
Names
PO
kidney and liver proline oxidase 1
probable proline dehydrogenase 2
probable proline oxidase 2
proline oxidase 1
proline oxidase-like protein
NP_001405449.1
NP_062419.2
XP_006540284.1
XP_006540285.1
XP_006540286.1
XP_006540287.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418520.1 → NP_001405449.1  hydroxyproline dehydrogenase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167970
    Related
    ENSMUST00000142514.8

  2. NM_019546.6 → NP_062419.2  hydroxyproline dehydrogenase isoform 1

    See identical proteins and their annotated locations for NP_062419.2

    Status: VALIDATED

    Source sequence(s)
    AC167970
    Consensus CDS
    CCDS21093.1
    UniProtKB/Swiss-Prot
    Q2V058, Q8VCZ9, Q9QX62
    Related
    ENSMUSP00000062214.7, ENSMUST00000058280.13
    Conserved Domains (1) summary
    pfam01619
    Location:218 → 439
    Pro_dh; Proline dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30193011..30212830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540221.2 → XP_006540284.1  hydroxyproline dehydrogenase isoform X1

    Conserved Domains (1) summary
    cl33545
    Location:80 → 439
    PutA_N; Proline utilization A N-terminal domain

  2. XM_006540222.3 → XP_006540285.1  hydroxyproline dehydrogenase isoform X2

    Conserved Domains (1) summary
    cl33545
    Location:47 → 372
    PutA_N; Proline utilization A N-terminal domain

  3. XM_006540224.4 → XP_006540287.1  hydroxyproline dehydrogenase isoform X4

    Conserved Domains (1) summary
    cl33545
    Location:47 → 373
    PutA_N; Proline utilization A N-terminal domain

  4. XM_006540223.1 → XP_006540286.1  hydroxyproline dehydrogenase isoform X3

    Conserved Domains (1) summary
    cl33545
    Location:13 → 403
    PutA_N; Proline utilization A N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCZ9.1 GenPept UniProtKB/Swiss-Prot:Q8VCZ9

Gene LinkOut

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