U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rabggta Rab geranylgeranyl transferase, a subunit [ Mus musculus (house mouse) ]

Gene ID: 56187, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Rabggtaprovided by MGI
Official Full Name
Rab geranylgeranyl transferase, a subunitprovided by MGI
Primary source
MGI:MGI:1860443
See related
Ensembl:ENSMUSG00000040472 AllianceGenome:MGI:1860443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gm
Summary
Enables Rab geranylgeranyltransferase activity. Acts upstream of or within protein geranylgeranylation. Predicted to be located in nucleoplasm. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Predicted to be active in cytoplasm. Used to study Hermansky-Pudlak syndrome. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 20.8), liver adult (RPKM 17.0) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
14 C3; 14 28.19 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55953321..55959720, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55715864..55722263, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene guanosine monophosphate reductase 2 Neighboring gene predicted gene, 25887 Neighboring gene STARR-seq mESC enhancer starr_36777 Neighboring gene transglutaminase 1, K polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E7317 Neighboring gene STARR-positive B cell enhancer ABC_E2425 Neighboring gene dehydrogenase/reductase 1 Neighboring gene NOP9 nucleolar protein Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector B

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function. Taylor A, et al. Small GTPases, 2011 May. PMID 21776414, Free PMC Article
  2. The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates. Coxon FP, et al. Bone, 2011 Jul. PMID 21419243
  3. Cell-specific abnormal prenylation of Rab proteins in platelets and melanocytes of the gunmetal mouse. Zhang Q, et al. Br J Haematol, 2002 May. PMID 11972527
  4. Increased incidence and analysis of emperipolesis in megakaryocytes of the mouse mutant gunmetal. McGarry MP, et al. Exp Mol Pathol, 1999 Aug. PMID 10486237
  5. Inherited abnormalities in platelet organelles and platelet formation and associated altered expression of low molecular weight guanosine triphosphate-binding proteins in the mouse pigment mutant gunmetal. Swank RT, et al. Blood, 1993 May 15. PMID 8490171

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Rab geranylgeranyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables Rab geranylgeranyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein geranylgeranylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein geranylgeranylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein prenylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rab-protein geranylgeranyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
geranylgeranyl transferase type-2 subunit alpha
Names
geranylgeranyl transferase type II subunit alpha
gunmetal
rab GG transferase alpha
rab GGTase alpha
rab geranylgeranyltransferase subunit alpha
NP_001347316.1
NP_001347317.1
NP_062392.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360387.1 → NP_001347316.1  geranylgeranyl transferase type-2 subunit alpha

    Status: VALIDATED

    Source sequence(s)
    AK002625, CD776583, CX213914
    Consensus CDS
    CCDS36933.1
    UniProtKB/Swiss-Prot
    Q9JHK4, Q9JLX2
    UniProtKB/TrEMBL
    Q3UIH7
    Related
    ENSMUSP00000128668.2, ENSMUST00000163889.3
    Conserved Domains (5) summary
    COG4886
    Location:354 → 520
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:443 → 461
    LRR_1; leucine-rich repeat [structural motif]
    pfam07711
    Location:247 → 346
    RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
    pfam14580
    Location:468 → 562
    LRR_9; Leucine-rich repeat
    cl27590
    Location:1 → 237
    PPTA; Protein prenyltransferase alpha subunit repeat

  2. NM_001360388.1 → NP_001347317.1  geranylgeranyl transferase type-2 subunit alpha

    Status: VALIDATED

    Source sequence(s)
    AF127656, BY150143, CD776583
    Consensus CDS
    CCDS36933.1
    UniProtKB/Swiss-Prot
    Q9JHK4, Q9JLX2
    UniProtKB/TrEMBL
    Q3UIH7
    Related
    ENSMUSP00000154725.2, ENSMUST00000227061.2
    Conserved Domains (5) summary
    COG4886
    Location:354 → 520
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:443 → 461
    LRR_1; leucine-rich repeat [structural motif]
    pfam07711
    Location:247 → 346
    RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
    pfam14580
    Location:468 → 562
    LRR_9; Leucine-rich repeat
    cl27590
    Location:1 → 237
    PPTA; Protein prenyltransferase alpha subunit repeat

  3. NM_019519.3 → NP_062392.1  geranylgeranyl transferase type-2 subunit alpha

    See identical proteins and their annotated locations for NP_062392.1

    Status: VALIDATED

    Source sequence(s)
    AF127658, CD776583
    Consensus CDS
    CCDS36933.1
    UniProtKB/Swiss-Prot
    Q9JHK4, Q9JLX2
    UniProtKB/TrEMBL
    Q3UIH7
    Related
    ENSMUSP00000133032.2, ENSMUST00000169237.8
    Conserved Domains (5) summary
    COG4886
    Location:354 → 520
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:443 → 461
    LRR_1; leucine-rich repeat [structural motif]
    pfam07711
    Location:247 → 346
    RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
    pfam14580
    Location:468 → 562
    LRR_9; Leucine-rich repeat
    cl27590
    Location:1 → 237
    PPTA; Protein prenyltransferase alpha subunit repeat

RNA

  1. NR_153435.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF127660, BY150143, CD776583
    Related
    ENSMUST00000228826.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55953321..55959720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHK4.1 GenPept UniProtKB/Swiss-Prot:Q9JHK4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous