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Ftsj3 FtsJ RNA 2'-O-methyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 56095, updated on 11-Apr-2024

Summary

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Official Symbol
Ftsj3provided by MGI
Official Full Name
FtsJ RNA 2'-O-methyltransferase 3provided by MGI
Primary source
MGI:MGI:1860295
See related
Ensembl:ENSMUSG00000020706 AllianceGenome:MGI:1860295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Epcs3; D11Ertd400e
Summary
Predicted to enable rRNA (guanine) methyltransferase activity and rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and rRNA methylation. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including central nervous system; gonad; liver; retina; and spleen. Orthologous to human FTSJ3 (FtsJ RNA 2'-O-methyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 24.5), liver E14 (RPKM 19.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E1; 11 68.89 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106139964..106146910, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106249138..106256084, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STE20-related kinase adaptor alpha Neighboring gene STARR-positive B cell enhancer ABC_E7078 Neighboring gene STARR-positive B cell enhancer ABC_E739 Neighboring gene coiled-coil domain containing 47 Neighboring gene STARR-positive B cell enhancer ABC_E5285 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106078089-106078198 Neighboring gene STARR-positive B cell enhancer ABC_E7080 Neighboring gene DEAD box helicase 42 Neighboring gene STARR-positive B cell enhancer ABC_E5286 Neighboring gene STARR-positive B cell enhancer ABC_E597 Neighboring gene protease (prosome, macropain) 26S subunit, ATPase 5 Neighboring gene predicted gene, 23645 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106130475-106130662 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E598

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of cDNA sequences from mouse testis. Kerr SM, et al. Mamm Genome, 1994 Sep. PMID 8000140
  2. Ott, a mouse X-linked multigene family expressed specifically during meiosis. Kerr SM, et al. Hum Mol Genet, 1996 Aug. PMID 8842733
  3. cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion. Hemberger M, et al. Dev Biol, 2000 Jun 1. PMID 10885754
  4. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
  5. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion.
    Title: RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA 2'-O-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (guanine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (uridine-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Names
2'-O-ribose RNA methyltransferase SPB1 homolog
FtsJ RNA methyltransferase homolog 3
FtsJ homolog 3
ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3
pre-rRNA processing protein FTSJ3
protein ftsJ homolog 3
putative rRNA methyltransferase 3
rRNA (uridine-2'-O-)-methyltransferase 3
NP_079586.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025310.3 → NP_079586.1  pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

    See identical proteins and their annotated locations for NP_079586.1

    Status: VALIDATED

    Source sequence(s)
    AL604045
    Consensus CDS
    CCDS25552.1
    UniProtKB/Swiss-Prot
    Q3ULI1, Q921I7, Q9DBE9
    Related
    ENSMUSP00000021048.7, ENSMUST00000021048.7
    Conserved Domains (3) summary
    COG0293
    Location:8 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
    pfam07780
    Location:636 → 825
    Spb1_C; Spb1 C-terminal domain
    pfam11861
    Location:232 → 398
    DUF3381; Domain of unknown function (DUF3381)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    106139964..106146910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBE9.1 GenPept UniProtKB/Swiss-Prot:Q9DBE9

Gene LinkOut

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