U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dnah10 dynein, axonemal, heavy chain 10 [ Mus musculus (house mouse) ]

Gene ID: 56087, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Dnah10provided by MGI
Official Full Name
dynein, axonemal, heavy chain 10provided by MGI
Primary source
MGI:MGI:1860299
See related
Ensembl:ENSMUSG00000038011 AllianceGenome:MGI:1860299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnahc10
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to act upstream of or within cilium movement. Predicted to be part of inner dynein arm. Predicted to be active in axoneme. Is expressed in embryo. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human DNAH10 (dynein axonemal heavy chain 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 4.7), lung adult (RPKM 1.5) and 1 other tissue See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5 F- G1.1; 5 63.78 cM
Exon count:
80
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124802149..124911372)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124725085..124834308)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10353 Neighboring gene STARR-seq mESC enhancer starr_14344 Neighboring gene tectonic family member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr5:125079413-125079714 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit A2 Neighboring gene coiled-coil domain containing 92 Neighboring gene zinc finger protein 664

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice. Tu C, et al. Am J Hum Genet, 2021 Aug 5. PMID 34237282, Free PMC Article
  2. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Neesen J, et al. Gene, 1997 Oct 24. PMID 9373155
  3. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice.
    Title: Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice.
  2. Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.
    Title: Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IC
Inferred by Curator
more info
 PubMed 
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium movement IC
Inferred by Curator
more info
 PubMed 
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of inner dynein arm ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
dynein axonemal heavy chain 10
Names
dynein, axon, heavy chain 10

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019536.1 → NP_062409.1  dynein axonemal heavy chain 10

    Status: PROVISIONAL

    Source sequence(s)
    AC164649, AC242457
    Consensus CDS
    CCDS51649.1
    UniProtKB/TrEMBL
    D3YYQ8, F7ABZ6
    Related
    ENSMUSP00000062995.9, ENSMUST00000058440.12
    Conserved Domains (6) summary
    pfam03028
    Location:3884 → 4580
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:306 → 878
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1377 → 1780
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:3165 → 3498
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:3527 → 3743
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:1914 → 2142
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124802149..124911372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165323.1 → XP_036021216.1  dynein axonemal heavy chain 10 isoform X1

    UniProtKB/TrEMBL
    F7ABZ6
    Conserved Domains (6) summary
    COG5245
    Location:563 → 3524
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:4 → 169
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:665 → 1070
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1205 → 1531
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2184 → 2443
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:3581 → 3879
    Dynein_C; Dynein heavy chain C-terminal domain

  2. XM_036165324.1 → XP_036021217.1  dynein axonemal heavy chain 10 isoform X2

    UniProtKB/TrEMBL
    F7ABZ6

  3. XM_036165326.1 → XP_036021219.1  dynein axonemal heavy chain 10 isoform X3

  4. XM_036165325.1 → XP_036021218.1  dynein axonemal heavy chain 10 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous