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Stard10 StAR related lipid transfer domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 56018, updated on 5-Mar-2024

Summary

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Official Symbol
Stard10provided by MGI
Official Full Name
StAR related lipid transfer domain containing 10provided by MGI
Primary source
MGI:MGI:1860093
See related
Ensembl:ENSMUSG00000030688 AllianceGenome:MGI:1860093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PCTP2; Pctpl; CGI-52; PC-TP2; TISP-81; NY-C0-28; Sdccag28; SdccagG28
Summary
Predicted to enable lipid binding activity. Acts upstream of or within bile acid secretion and positive regulation of peroxisome proliferator activated receptor signaling pathway. Located in several cellular components, including cytosol; intercellular canaliculus; and microvillus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and liver and biliary system. Orthologous to human STARD10 (StAR related lipid transfer domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 468.9), colon adult (RPKM 328.7) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E2; 7 54.55 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100966293..100995833)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101317086..101346626)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene FCH and double SH3 domains 2 Neighboring gene predicted gene, 57508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:108450776-108450959 Neighboring gene STARR-seq mESC enhancer starr_19689 Neighboring gene STARR-positive B cell enhancer ABC_E1349 Neighboring gene autophagy related 16 like 2 Neighboring gene predicted gene 20476 Neighboring gene STARR-seq mESC enhancer starr_19692 Neighboring gene STARR-positive B cell enhancer ABC_E4957 Neighboring gene predicted gene, 35219 Neighboring gene STARR-positive B cell enhancer ABC_E1740 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Neighboring gene phosphodiesterase 2A, cGMP-stimulated Neighboring gene microRNA 139

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of phosphatidylcholine transfer protein-like protein gene expressed in murine haploid germ cells. Yamanaka M, et al. Biol Reprod, 2000 Jun. PMID 10819773
  2. The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Carrat GR, et al. Mol Metab, 2020 Oct. PMID 32416313, Free PMC Article
  3. Star-related lipid transfer protein 10 (STARD10): a novel key player in alcohol-induced breast cancer progression. Floris A, et al. J Exp Clin Cancer Res, 2019 Jan 5. PMID 30611309, Free PMC Article
  4. Transcriptional profiling of the heart reveals chamber-specific gene expression patterns. Tabibiazar R, et al. Circ Res, 2003 Dec 12. PMID 14576202
  5. Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically Interacts with Phospholipid Transfer Protein StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type II Cells. Lin S, et al. J Biol Chem, 2015 Jul 24. PMID 26048993, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.
    Title: The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.
  2. StarD10 is required for normal insulin secretion, though its deletion enhances proinsulin processing.
    Title: Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.
  3. LPCAT1 interacts with StarD10 and that amino acids 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction.
    Title: Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically Interacts with Phospholipid Transfer Protein StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type II Cells.
  4. results indicate that STARD10 is involved in regulating bile acid metabolism through the modulation of PPARalpha-mediated mechanism.
    Title: Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis.
  5. Stard10 (Sdccag28) is much more highly transcribed in cardiac atria than in cardiac ventricles.
    Title: Transcriptional profiling of the heart reveals chamber-specific gene expression patterns.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bile acid secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in intercellular canaliculus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intercellular canaliculus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microvillus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
START domain-containing protein 10
Names
PCTP-L
PCTP-like protein
START domain containing 10
serologically defined colon cancer antigen 10
serologically defined colon cancer antigen 28 homolog
stAR-related lipid transfer protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360460.1 → NP_001347389.1  START domain-containing protein 10 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC107638, AC129079
    Consensus CDS
    CCDS90281.1
    UniProtKB/TrEMBL
    E9PVP0, Q5RL65
    Related
    ENSMUSP00000129408.3, ENSMUST00000163799.9
    Conserved Domains (1) summary
    cd08871
    Location:92 → 314
    START_STARD10-like; Lipid-binding START domain of mammalian STARD10 and related proteins

  2. NM_019990.5 → NP_064374.1  START domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_064374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC129079
    Consensus CDS
    CCDS21509.1
    UniProtKB/Swiss-Prot
    Q9JMD3
    UniProtKB/TrEMBL
    Q0VG22, Q52LA1
    Related
    ENSMUSP00000032927.8, ENSMUST00000032927.14
    Conserved Domains (1) summary
    cd08871
    Location:19 → 241
    START_STARD10-like; Lipid-binding START domain of mammalian STARD10 and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100966293..100995833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153267.1 → XP_036009160.1  START domain-containing protein 10 isoform X1

    UniProtKB/Swiss-Prot
    Q9JMD3
    UniProtKB/TrEMBL
    Q0VG22, Q52LA1
    Conserved Domains (1) summary
    cd08871
    Location:19 → 241
    START_STARD10-like; Lipid-binding START domain of mammalian STARD10 and related proteins

  2. XM_030242807.1 → XP_030098667.1  START domain-containing protein 10 isoform X1

    UniProtKB/Swiss-Prot
    Q9JMD3
    UniProtKB/TrEMBL
    Q0VG22, Q52LA1
    Related
    ENSMUSP00000133002.3, ENSMUST00000164479.9
    Conserved Domains (1) summary
    cd08871
    Location:19 → 241
    START_STARD10-like; Lipid-binding START domain of mammalian STARD10 and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMD3.1 GenPept UniProtKB/Swiss-Prot:Q9JMD3

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