Hebp2 heme binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hebp2provided by MGI
Official Full Name: heme binding protein 2provided by MGI
Primary source: MGI:MGI:1860084
See related: Ensembl:ENSMUSG00000019853 AllianceGenome:MGI:1860084
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SOUL
Summary: Predicted to enable heme binding activity. Predicted to be involved in negative regulation of mitochondrial membrane potential; positive regulation of mitochondrial membrane permeability; and positive regulation of necrotic cell death. Located in cytoplasm. Orthologous to human HEBP2 (heme binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 8.6), genital fat pad adult (RPKM 4.6) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 7.76 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (18415871..18421824, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (18540123..18546076, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results provide a better understanding of the target recognition mechanism and conformational change of SOUL in the interaction with ALG-2.
Title: Thermodynamic Characterization of the Ca(2+)-Dependent Interaction Between SOUL and ALG-2.
The heme-binding properties and coordination structure of SOUL protein are distinct from those of mouse liver p22HBP, despite high sequence homology.
Title: SOUL in mouse eyes is a new hexameric heme-binding protein with characteristic optical absorption, resonance Raman spectral, and heme-binding properties.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heme-binding protein 2

Names: putative heme-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.