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Nop58 NOP58 ribonucleoprotein [ Mus musculus (house mouse) ]

Gene ID: 55989, updated on 11-Apr-2024

Summary

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Official Symbol
Nop58provided by MGI
Official Full Name
NOP58 ribonucleoproteinprovided by MGI
Primary source
MGI:MGI:1933184
See related
Ensembl:ENSMUSG00000026020 AllianceGenome:MGI:1933184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SIK; MSSP; Nol5; nop5
Summary
Predicted to enable ATPase binding activity; TFIID-class transcription factor complex binding activity; and snoRNA binding activity. Predicted to be involved in snoRNA localization. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in Cajal body; cytosol; and fibrillar center. Predicted to be part of box C/D RNP complex; pre-snoRNP complex; and small-subunit processome. Is expressed in brain; embryo; eye; heart; and pancreas epithelium. Orthologous to human NOP58 (NOP58 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 41.5), liver E14 (RPKM 35.5) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Nop58 in Genome Data Viewer
Location:
1 C2; 1 30.38 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59724165..59751352)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59684961..59711510)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 973 Neighboring gene predicted gene, 33833 Neighboring gene STARR-seq mESC enhancer starr_01052 Neighboring gene STARR-positive B cell enhancer ABC_E9465 Neighboring gene small ubiquitin-like modifier 1 Neighboring gene STARR-positive B cell enhancer ABC_E2544 Neighboring gene STARR-seq mESC enhancer starr_01053 Neighboring gene small nucleolar RNA, C/D box 70 Neighboring gene predicted gene, 26293 Neighboring gene STARR-seq mESC enhancer starr_01054 Neighboring gene predicted gene, 26287 Neighboring gene small nucleolar RNA, C/D box 11 Neighboring gene RIKEN cDNA B430105G09 gene Neighboring gene bone morphogenetic protein receptor type 2 Neighboring gene STARR-seq mESC enhancer starr_01055

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleolar Sik-similar protein (Sik-SP) is required for the maintenance of uterine estrogen signaling mechanism via ERα. Chung D, et al. Mol Endocrinol, 2012 Mar. PMID 22282469, Free PMC Article
  2. Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp140. Yang Y, et al. Mol Biol Cell, 2000 Feb. PMID 10679015, Free PMC Article
  3. SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. Marie-Cardine A, et al. J Exp Med, 1999 Apr 19. PMID 10209036, Free PMC Article
  4. LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Wang X, et al. Mol Cell, 2020 Mar 5. PMID 32017896
  5. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105209

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables TFIID-class transcription factor complex binding ISO
Inferred from Sequence Orthology
more info
  
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables snoRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in snoRNA localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
part_of box C/D methylation guide snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of box C/D methylation guide snoRNP complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of pre-snoRNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of sno(s)RNA-containing ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleolar protein 58
Names
NOP58 ribonucleoprotein homolog
SIK similar protein
nucleolar protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420730.1 → NP_001407659.1  nucleolar protein 58 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC147254

  2. NM_001420731.1 → NP_001407660.1  nucleolar protein 58 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC147254

  3. NM_001420732.1 → NP_001407661.1  nucleolar protein 58 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC147254

  4. NM_001420733.1 → NP_001407662.1  nucleolar protein 58 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC147254

  5. NM_001420734.1 → NP_001407663.1  nucleolar protein 58 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC147254

  6. NM_001420735.1 → NP_001407664.1  nucleolar protein 58 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC147254

  7. NM_001420736.1 → NP_001407665.1  nucleolar protein 58 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC147254

  8. NM_001420737.1 → NP_001407666.1  nucleolar protein 58 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC147254

  9. NM_001420738.1 → NP_001407667.1  nucleolar protein 58 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC147254

  10. NM_001420739.1 → NP_001407668.1  nucleolar protein 58 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC147254

  11. NM_001420740.1 → NP_001407669.1  nucleolar protein 58 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC147254

  12. NM_001420741.1 → NP_001407670.1  nucleolar protein 58 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC147254

  13. NM_018868.3 → NP_061356.2  nucleolar protein 58 isoform 1

    See identical proteins and their annotated locations for NP_061356.2

    Status: VALIDATED

    Source sequence(s)
    AC147254
    Consensus CDS
    CCDS35587.1
    UniProtKB/Swiss-Prot
    O70396, Q3UYX9, Q3UZA3, Q6DFW4, Q8C8Y7
    Related
    ENSMUSP00000140250.2, ENSMUST00000191142.7
    Conserved Domains (3) summary
    smart00931
    Location:162 → 213
    NOSIC; NOSIC (NUC001) domain
    pfam01798
    Location:168 → 396
    Nop; snoRNA binding domain, fibrillarin
    pfam08156
    Location:2 → 66
    NOP5NT; NOP5NT (NUC127) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    59724165..59751352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DFW4.1 GenPept UniProtKB/Swiss-Prot:Q6DFW4

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