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Cxcl13 C-X-C motif chemokine ligand 13 [ Mus musculus (house mouse) ]

Gene ID: 55985, updated on 9-Dec-2024

Summary

Official Symbol
Cxcl13provided by MGI
Official Full Name
C-X-C motif chemokine ligand 13provided by MGI
Primary source
MGI:MGI:1888499
See related
Ensembl:ENSMUSG00000023078 AllianceGenome:MGI:1888499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BLC; Angie; BCA-1; BLR1L; ANGIE2; Scyb13; 4631412M08Rik
Summary
Enables CXCR5 chemokine receptor binding activity and chemokine activity. Involved in several processes, including B cell chemotaxis across high endothelial venule; activation of GTPase activity; and lymph node development. Located in extracellular space. Is expressed in Peyer's patch; aorta; central nervous system; and retina. Orthologous to human CXCL13 (C-X-C motif chemokine ligand 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in spleen adult (RPKM 19.2), mammary gland adult (RPKM 8.1) and 6 other tissues See more
Orthologs
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Genomic context

See Cxcl13 in Genome Data Viewer
Location:
5 E3; 5 47.29 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (96104785..96108927)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (95956939..95961068)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 25937 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13673 Neighboring gene CCR4-NOT transcription complex, subunit 6-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:96589986-96590095 Neighboring gene STARR-positive B cell enhancer mm9_chr5:96592485-96592786

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (8) 
  • Targeted (2)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR10 chemokine receptor binding  
enables CCR10 chemokine receptor binding  
enables CXCR chemokine receptor binding  
enables CXCR3 chemokine receptor binding  
enables CXCR3 chemokine receptor binding  
enables CXCR5 chemokine receptor binding PubMed 
enables CXCR5 chemokine receptor binding  
enables chemokine activity  
enables chemokine activity PubMed 
enables chemokine activity  
enables fibroblast growth factor binding  
enables fibroblast growth factor binding  
enables heparin binding  
enables heparin binding  
enables receptor ligand activity  
enables receptor ligand activity  
Items 1 - 25 of 30
Process Evidence Code Pubs
involved_in B cell chemotaxis PubMed 
involved_in B cell chemotaxis  
involved_in B cell chemotaxis across high endothelial venule PubMed 
involved_in activation of GTPase activity PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
involved_in cell surface receptor signaling pathway  
involved_in cell-cell signaling  
involved_in cell-cell signaling  
involved_in cellular response to lipopolysaccharide  
involved_in chemokine-mediated signaling pathway PubMed 
involved_in defense response to bacterium  
involved_in defense response to bacterium  
involved_in endothelial cell chemotaxis to fibroblast growth factor  
involved_in endothelial cell chemotaxis to fibroblast growth factor  
involved_in immune response  
involved_in inflammatory response  
involved_in inflammatory response  
involved_in killing of cells of another organism  
involved_in lymph node development PubMed 
acts_upstream_of_or_within lymph node development PubMed 
involved_in lymphocyte chemotaxis across high endothelial venule PubMed 
involved_in negative regulation of endothelial cell chemotaxis to fibroblast growth factor  
involved_in neutrophil chemotaxis  
involved_in positive regulation of T cell chemotaxis  
involved_in positive regulation of T cell chemotaxis  
involved_in positive regulation of cell-cell adhesion mediated by integrin PubMed 
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of integrin activation PubMed 
Items 1 - 25 of 30
Component Evidence Code Pubs
located_in extracellular region  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 

General protein information

Preferred Names
C-X-C motif chemokine 13
Names
B lymphocyte chemoattractant
CXC chemokine BLC
chemokine (C-X-C motif) ligand 13
small inducible cytokine subfamily B (Cys-X-Cys), member 13
small-inducible cytokine B13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018866.3NP_061354.1  C-X-C motif chemokine 13 precursor

    See identical proteins and their annotated locations for NP_061354.1

    Status: VALIDATED

    Source sequence(s)
    AC146611
    Consensus CDS
    CCDS19447.1
    UniProtKB/Swiss-Prot
    O55038
    UniProtKB/TrEMBL
    Q3U1E8
    Related
    ENSMUSP00000023840.6, ENSMUST00000023840.7
    Conserved Domains (1) summary
    cd00273
    Location:2992
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    96104785..96108927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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