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LIN37 lin-37 DREAM MuvB core complex component [ Homo sapiens (human) ]

Gene ID: 55957, updated on 5-Mar-2024

Summary

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Official Symbol
LIN37provided by HGNC
Official Full Name
lin-37 DREAM MuvB core complex componentprovided by HGNC
Primary source
HGNC:HGNC:33234
See related
Ensembl:ENSG00000267796 AllianceGenome:HGNC:33234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F25965; lin-37; ZK418.4
Summary
This gene encodes a protein expressed in the eye. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 7.7), placenta (RPKM 6.8) and 25 other tissues See more
Orthologs
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Genomic context

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See LIN37 in Genome Data Viewer
Location:
19q13.12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35748576..35754519)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38293885..38299832)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36239477..36245420)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14497 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:36234871-36235031 Neighboring gene U2 small nuclear RNA auxiliary factor 1 like 4 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36238731-36239245 Neighboring gene presenilin enhancer, gamma-secretase subunit Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36239246-36239760 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36248182-36248753 Neighboring gene heat shock protein family B (small) member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14501 Neighboring gene proline and serine rich 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36257953-36258804

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation. Uxa S, et al. Nucleic Acids Res, 2019 Sep 26. PMID 31400114, Free PMC Article
  2. The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb. Iness AN, et al. Oncogene, 2019 Feb. PMID 30206359, Free PMC Article
  3. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Litovchick L, et al. Genes Dev, 2011 Apr 15. PMID 21498570, Free PMC Article
  4. Structural mechanisms of DREAM complex assembly and regulation. Guiley KZ, et al. Genes Dev, 2015 May 1. PMID 25917549, Free PMC Article
  5. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. Schmit F, et al. Cell Cycle, 2007 Aug 1. PMID 17671431

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abrogation of DREAM function by knockout of the DREAM component LIN37 results in a reduced repression of cell-cycle genes.
    Title: DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: PSENEN

Homology

Clone Names

  • MGC9505

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Myb complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of transcription repressor complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein lin-37 homolog
Names
antolefinin
lin-37 homolog
protein F25965

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369780.1 → NP_001356709.1  protein lin-37 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC002398, AD000671, KC877720, KC877725
    Conserved Domains (1) summary
    pfam15306
    Location:70 → 226
    LIN37

  2. NM_019104.3 → NP_061977.1  protein lin-37 homolog isoform 1

    See identical proteins and their annotated locations for NP_061977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC009071, CB152701, DC396639
    Consensus CDS
    CCDS62642.1
    UniProtKB/Swiss-Prot
    A8KAQ1, O14557, Q7Z2T9, Q96GY3
    Related
    ENSP00000301159.7, ENST00000301159.14
    Conserved Domains (1) summary
    pfam15306
    Location:84 → 240
    LIN37

RNA

  1. NR_163146.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC002398, AD000671, KC877720, KC877725

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35748576..35754519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    38293885..38299832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96GY3.1 GenPept UniProtKB/Swiss-Prot:Q96GY3

Gene LinkOut

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