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Eef1b2 eukaryotic translation elongation factor 1 beta 2 [ Mus musculus (house mouse) ]

Gene ID: 55949, updated on 11-Apr-2024

Summary

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Official Symbol
Eef1b2provided by MGI
Official Full Name
eukaryotic translation elongation factor 1 beta 2provided by MGI
Primary source
MGI:MGI:1929520
See related
Ensembl:ENSMUSG00000025967 AllianceGenome:MGI:1929520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eef1b; EF-1-beta; 2810017J07Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and translation elongation factor activity. Predicted to be involved in response to ethanol and translational elongation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Predicted to colocalize with endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and hemolymphoid system gland. Orthologous to human EEF1B2 (eukaryotic translation elongation factor 1 beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 172.4), liver E14 (RPKM 139.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Eef1b2 in Genome Data Viewer
Location:
1 C2; 1 32.31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63215990..63219645)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63176831..63180486)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene INO80 complex subunit D Neighboring gene ribosomal protein S27, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2545 Neighboring gene STARR-seq mESC enhancer starr_01125 Neighboring gene INO80 complex subunit D, opposite strand Neighboring gene STARR-seq mESC enhancer starr_01129 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S1 Neighboring gene STARR-positive B cell enhancer ABC_E1994 Neighboring gene STARR-positive B cell enhancer ABC_E3279 Neighboring gene STARR-seq mESC enhancer starr_01131 Neighboring gene predicted gene, 26457 Neighboring gene small nucleolar RNA, H/ACA box 41 Neighboring gene STARR-seq mESC enhancer starr_01132 Neighboring gene chemerin chemokine-like receptor 2 Neighboring gene STARR-seq mESC enhancer starr_01135 Neighboring gene zinc finger, DBF-type containing 2 Neighboring gene RIKEN cDNA 1700039I01 gene Neighboring gene STARR-seq mESC enhancer starr_01137

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and tissue expression analysis of the beta subunit of elongation factor 1 in the mouse. Liu Q, et al. Biochem Genet, 2000 Apr. PMID 11100270
  2. Proteome analysis of mouse brain: two-dimensional electrophoresis profiles of tissue proteins during the course of aging. Tsugita A, et al. Electrophoresis, 2000 May. PMID 10870971
  3. The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammals. Duffié R, et al. Genes Dev, 2014 Mar 1. PMID 24589776, Free PMC Article
  4. Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. Shu H, et al. Mol Cell Proteomics, 2004 Mar. PMID 14729942
  5. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation elongation factor 1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
elongation factor 1-beta
Names
eukaryotic translation elongation factor 1-beta homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018796.3 → NP_061266.2  elongation factor 1-beta

    See identical proteins and their annotated locations for NP_061266.2

    Status: VALIDATED

    Source sequence(s)
    AK027911, AL645950
    Consensus CDS
    CCDS14997.1
    UniProtKB/Swiss-Prot
    O70251, Q3THP5, Q5SUH1, Q8CHS1, Q99L22, Q9CZD4
    UniProtKB/TrEMBL
    A0A087WS46
    Related
    ENSMUSP00000116492.2, ENSMUST00000129339.8
    Conserved Domains (3) summary
    cd10308
    Location:3 → 62
    GST_C_eEF1b_like; Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
    pfam00736
    Location:142 → 225
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:103 → 130
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    63215990..63219645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70251.5 GenPept UniProtKB/Swiss-Prot:O70251

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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