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Ap3m1 adaptor-related protein complex 3, mu 1 subunit [ Mus musculus (house mouse) ]

Gene ID: 55946, updated on 11-Apr-2024

Summary

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Official Symbol
Ap3m1provided by MGI
Official Full Name
adaptor-related protein complex 3, mu 1 subunitprovided by MGI
Primary source
MGI:MGI:1929212
See related
Ensembl:ENSMUSG00000021824 AllianceGenome:MGI:1929212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200013D09Rik
Summary
Predicted to enable small GTPase binding activity. Involved in anterograde synaptic vesicle transport. Predicted to be located in Golgi apparatus and membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in cytoplasmic vesicle. Orthologous to human AP3M1 (adaptor related protein complex 3 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 16.1), CNS E11.5 (RPKM 13.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 11.58 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21083810..21102603, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21033106..21052553, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene vinculin Neighboring gene predicted gene, 52168 Neighboring gene STARR-seq mESC enhancer starr_36125 Neighboring gene uncharacterized protein C3orf14 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_36127 Neighboring gene adenosine kinase Neighboring gene VISTA enhancer mm1738 Neighboring gene STARR-seq mESC enhancer starr_36134 Neighboring gene predicted gene, 30363

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex. Mardones GA, et al. J Biol Chem, 2013 Mar 29. PMID 23404500, Free PMC Article
  2. Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1. Nie Z, et al. Dev Cell, 2003 Sep. PMID 12967569
  3. Association of the AP-3 adaptor complex with clathrin. Dell'Angelica EC, et al. Science, 1998 Apr 17. PMID 9545220
  4. Characterization of the adaptor-related protein complex, AP-3. Simpson F, et al. J Cell Biol, 1997 May 19. PMID 9151686, Free PMC Article
  5. Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway. Steinmetz CC, et al. Cell Rep, 2016 Sep 6. PMID 27568566, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data suggest that excess mu3A acts independently of the AP-3A complex to reroute AMPAR to recycling endosomes.
    Title: Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.
  2. Structural basis for the recognition of tyrosine-based sorting signals by the mu3A subunit of the AP-3 adaptor complex
    Title: Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in anterograde synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin-coated vesicle cargo loading, AP-3-mediated NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in melanosome assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in platelet dense granule organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-3 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AP-3 complex subunit mu-1
Names
AP-3 adapter complex mu3A subunit
AP-3 adaptor complex mu3A subunit
adapter-related protein complex 3 mu-1 subunit
adapter-related protein complex 3 subunit mu-1
adaptor-related protein complex 3 subunit mu-1
adaptor-related protein complex AP-3, mu 1 subunit
clathrin adaptor protein mu3A
mu-adaptin 3A
mu3A-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018829.4 → NP_061299.3  AP-3 complex subunit mu-1

    See identical proteins and their annotated locations for NP_061299.3

    Status: VALIDATED

    Source sequence(s)
    AC163681, BC090983, BY774570, CD551381
    Consensus CDS
    CCDS26861.1
    UniProtKB/Swiss-Prot
    Q5BKQ6, Q9JKC8
    UniProtKB/TrEMBL
    Q9DBU8
    Related
    ENSMUSP00000117346.2, ENSMUST00000154460.8
    Conserved Domains (2) summary
    cd09260
    Location:165 → 418
    AP-3_Mu3A_Cterm; C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    21083810..21102603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519292.3 → XP_006519355.1  AP-3 complex subunit mu-1 isoform X1

    See identical proteins and their annotated locations for XP_006519355.1

    UniProtKB/Swiss-Prot
    Q5BKQ6, Q9JKC8
    UniProtKB/TrEMBL
    Q9DBU8
    Conserved Domains (2) summary
    cd09260
    Location:165 → 418
    AP-3_Mu3A_Cterm; C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain

  2. XM_006519293.3 → XP_006519356.1  AP-3 complex subunit mu-1 isoform X1

    See identical proteins and their annotated locations for XP_006519356.1

    UniProtKB/Swiss-Prot
    Q5BKQ6, Q9JKC8
    UniProtKB/TrEMBL
    Q9DBU8
    Related
    ENSMUSP00000022371.4, ENSMUST00000022371.10
    Conserved Domains (2) summary
    cd09260
    Location:165 → 418
    AP-3_Mu3A_Cterm; C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain

RNA

  1. XR_003950866.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKC8.1 GenPept UniProtKB/Swiss-Prot:Q9JKC8

Gene LinkOut

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