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Fnbp4 formin binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 55935, updated on 5-Mar-2024

Summary

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Official Symbol
Fnbp4provided by MGI
Official Full Name
formin binding protein 4provided by MGI
Primary source
MGI:MGI:1860513
See related
Ensembl:ENSMUSG00000008200 AllianceGenome:MGI:1860513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBP30; Fnbp30; mKIAA1014
Summary
Predicted to be located in nuclear speck. Is expressed in endolymphatic appendage and otocyst. Orthologous to human FNBP4 (formin binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 22.6), CNS E11.5 (RPKM 22.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E1; 2 50.35 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90575793..90611365)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90745454..90781021)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:90481961-90482070 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90490258-90490559 Neighboring gene predicted gene, 39871 Neighboring gene STARR-positive B cell enhancer ABC_E7838 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90519352-90519653 Neighboring gene STARR-seq mESC enhancer starr_05093 Neighboring gene nucleoporin 160 Neighboring gene STARR-seq mESC enhancer starr_05095 Neighboring gene predicted gene, 39872 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:90585318-90585501 Neighboring gene ribosomal protein L30, pseudogene 3 Neighboring gene ATP/GTP binding protein-like 2 Neighboring gene STARR-seq mESC enhancer starr_05097 Neighboring gene predicted gene 13772 Neighboring gene STARR-seq mESC enhancer starr_05098 Neighboring gene STARR-positive B cell enhancer ABC_E11147 Neighboring gene STARR-positive B cell enhancer ABC_E9517 Neighboring gene mitochondrial carrier 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Ruivenkamp CA, et al. Nat Genet, 2002 Jul. PMID 12089527
  2. Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1. Zucconi A, et al. J Mol Biol, 2001 Apr 13. PMID 11292345
  3. A novel pro-Arg motif recognized by WW domains. Bedford MT, et al. J Biol Chem, 2000 Apr 7. PMID 10744724
  4. Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. Chan DC, et al. EMBO J, 1996 Mar 1. PMID 8605874, Free PMC Article
  5. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
formin-binding protein 4
Names
formin binding protein 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421559.1 → NP_001408488.1  formin-binding protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL714026

  2. NM_001421560.1 → NP_001408489.1  formin-binding protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL714026

  3. NM_001421561.1 → NP_001408490.1  formin-binding protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL714026

  4. NM_001421562.1 → NP_001408491.1  formin-binding protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL714026

  5. NM_018828.3 → NP_061298.2  formin-binding protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL714026
    Consensus CDS
    CCDS16414.2
    UniProtKB/Swiss-Prot
    Q3TPA6, Q6ZQ03, Q8BNC8, Q9JHC1
    UniProtKB/TrEMBL
    A0A5F8MPU2
    Related
    ENSMUSP00000159108.2, ENSMUST00000238890.2
    Conserved Domains (2) summary
    cd00201
    Location:605 → 636
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:222 → 249
    WW; WW domain

RNA

  1. NR_185311.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL714026

  2. NR_185312.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL714026

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    90575793..90611365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162404.1 → XP_036018297.1  formin-binding protein 4 isoform X1

    Conserved Domains (1) summary
    cd00201
    Location:115 → 146
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RNA

  1. XR_001783149.3 RNA Sequence

  2. XR_003953674.2 RNA Sequence

  3. XR_004940671.1 RNA Sequence

  4. XR_004940672.1 RNA Sequence

  5. XR_004940673.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQ03.2 GenPept UniProtKB/Swiss-Prot:Q6ZQ03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
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