U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gbp3 guanylate binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 55932, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gbp3provided by MGI
Official Full Name
guanylate binding protein 3provided by MGI
Primary source
MGI:MGI:1926263
See related
Ensembl:ENSMUSG00000028268 AllianceGenome:MGI:1926263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gbp4; GBP-3; GBP-4
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Acts upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and defense response to other organism. Located in cytoplasmic vesicle; cytosol; and symbiont-containing vacuole membrane. Orthologous to human GBP4 (guanylate binding protein 4) and GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 10.8), subcutaneous fat pad adult (RPKM 6.0) and 21 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gbp3 in Genome Data Viewer
Location:
3 H1; 3 66.69 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142265781..142278974)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142560016..142573213)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 5 Neighboring gene guanylate binding protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E3478 Neighboring gene predicted gene, 40158 Neighboring gene STARR-positive B cell enhancer ABC_E10218 Neighboring gene STARR-positive B cell enhancer mm9_chr3:142263123-142263423 Neighboring gene guanylate binding protein 2b Neighboring gene STARR-positive B cell enhancer mm9_chr3:142282846-142283147 Neighboring gene predicted gene, 54185 Neighboring gene microRNA 6381 Neighboring gene guanylate binding protein 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase. Vestal DJ, et al. J Interferon Cytokine Res, 2011 Jan. PMID 21142871, Free PMC Article
  2. GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair. Xu H, et al. Oncogene, 2022 Jul. PMID 35780181
  3. GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis. Xu H, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29128363
  4. Cloning, expression, and characterization of a novel guanylate-binding protein, GBP3 in murine erythroid progenitor cells. Han BH, et al. Biochim Biophys Acta, 1998 May 19. PMID 9659399
  5. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Meunier E, et al. Nature, 2014 May 15. PMID 24739961

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis.
    Title: Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis.
  2. GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
    Title: GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
  3. GBP3 over-expression promotes glioma growth in mice and is inversely correlated with patients survival rate.
    Title: GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adhesion of symbiont to host IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytolysis in another organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to protozoan IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of pyroptosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in symbiont-containing vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
guanylate-binding protein 3
Names
GTP-binding protein 3
GTP-binding protein 4
guanine nucleotide-binding protein 3
guanine nucleotide-binding protein 4
guanylate nucleotide binding protein 3
guanylate nucleotide binding protein 4
guanylate-binding protein 4
putative purine nucleotide binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289492.3 → NP_001276421.1  guanylate-binding protein 3

    See identical proteins and their annotated locations for NP_001276421.1

    Status: VALIDATED

    Source sequence(s)
    AC102108, AK132266, CK389037
    Consensus CDS
    CCDS17879.1
    UniProtKB/Swiss-Prot
    Q61107, Q8VEC5
    Related
    ENSMUSP00000029935.8, ENSMUST00000029935.14
    Conserved Domains (2) summary
    pfam02263
    Location:12 → 275
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:277 → 573
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_001289493.2 → NP_001276422.1  guanylate-binding protein 3

    See identical proteins and their annotated locations for NP_001276422.1

    Status: VALIDATED

    Source sequence(s)
    AC102108, AK132266, CK389037
    Consensus CDS
    CCDS17879.1
    UniProtKB/Swiss-Prot
    Q61107, Q8VEC5
    Related
    ENSMUSP00000101828.2, ENSMUST00000106221.8
    Conserved Domains (2) summary
    pfam02263
    Location:12 → 275
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:277 → 573
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. NM_001355403.2 → NP_001342332.1  guanylate-binding protein 3

    Status: VALIDATED

    Source sequence(s)
    AC102108
    Consensus CDS
    CCDS17879.1
    UniProtKB/Swiss-Prot
    Q61107, Q8VEC5
    Conserved Domains (2) summary
    pfam02263
    Location:12 → 275
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:277 → 573
    GBP_C; Guanylate-binding protein, C-terminal domain

  4. NM_018734.4 → NP_061204.3  guanylate-binding protein 3

    See identical proteins and their annotated locations for NP_061204.3

    Status: VALIDATED

    Source sequence(s)
    AA162247, AC102108, AK132266
    Consensus CDS
    CCDS17879.1
    UniProtKB/Swiss-Prot
    Q61107, Q8VEC5
    Related
    ENSMUSP00000101829.3, ENSMUST00000106222.9
    Conserved Domains (2) summary
    pfam02263
    Location:12 → 275
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:277 → 573
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    142265781..142278974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501719.3 → XP_006501782.1  guanylate-binding protein 3 isoform X1

    Conserved Domains (2) summary
    pfam02263
    Location:72 → 335
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:337 → 633
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_006501724.3 → XP_006501787.1  guanylate-binding protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006501787.1

    UniProtKB/Swiss-Prot
    Q61107, Q8VEC5
    Conserved Domains (2) summary
    pfam02263
    Location:12 → 275
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:277 → 573
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61107.1 GenPept UniProtKB/Swiss-Prot:Q61107

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous