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WSB2 WD repeat and SOCS box containing 2 [ Homo sapiens (human) ]

Gene ID: 55884, updated on 5-Mar-2024

Summary

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Official Symbol
WSB2provided by HGNC
Official Full Name
WD repeat and SOCS box containing 2provided by HGNC
Primary source
HGNC:HGNC:19222
See related
Ensembl:ENSG00000176871 AllianceGenome:HGNC:19222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBA2
Summary
This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in brain (RPKM 65.4), thyroid (RPKM 28.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
12q24.23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (118032687..118062174, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (118019987..118049474, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (118470492..118499979, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370012 Neighboring gene Sharpr-MPRA regulatory region 11046 Neighboring gene kinase suppressor of ras 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118021615-118022115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118066292-118066792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118066793-118067293 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118078225-118078724 Neighboring gene uncharacterized LOC105370011 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118274024-118274569 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:118284773-118285290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118312867-118313667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4919 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118442171-118442363 Neighboring gene MPRA-validated peak1990 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24987 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7106 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:118489679-118490878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4921 Neighboring gene uncharacterized LOC124903030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118523172-118523714 Neighboring gene replication factor C subunit 5 Neighboring gene uncharacterized LOC124903029 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4922 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:118543551-118544266 Neighboring gene Sharpr-MPRA regulatory region 1292 Neighboring gene uncharacterized LOC101928274 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancers GRCh37_chr12:118557876-118558588 and GRCh37_chr12:118558589-118559300 Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118560014-118560725 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118560726-118561438 Neighboring gene Sharpr-MPRA regulatory region 10186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118564319-118564855 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118573724-118574224

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. WD repeat and SOCS box containing protein 2 in the proliferation, cycle progression, and migration of melanoma cells. Zhang Y, et al. Biomed Pharmacother, 2019 Aug. PMID 31103822
  2. Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer. Li XG, et al. World J Gastroenterol, 2001 Aug. PMID 11819827, Free PMC Article
  3. miR‑28‑5p inhibits the migration of breast cancer by regulating WSB2. Ma L, et al. Int J Mol Med, 2020 Oct. PMID 32945370, Free PMC Article
  4. Regulation of interleukin-21 receptor expression and its signal transduction by WSB-2. Nara H, et al. Biochem Biophys Res Commun, 2010 Feb 5. PMID 20059963
  5. Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling. Erkeland SJ, et al. Oncogene, 2007 Mar 29. PMID 17001306

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma.
    Title: Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma.
  2. miR285p inhibits the migration of breast cancer by regulating WSB2.
    Title: miR‑28‑5p inhibits the migration of breast cancer by regulating WSB2.
  3. This is the first report to demonstrate the effects of WSB2 on melanoma cell function.
    Title: WD repeat and SOCS box containing protein 2 in the proliferation, cycle progression, and migration of melanoma cells.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. This report provides the first evidence that WSB-2 is a regulator of IL-21R expression and IL-21-induced signal transduction.
    Title: Regulation of interleukin-21 receptor expression and its signal transduction by WSB-2.
  6. SBA2 gene might be a promising novel biomarker of cell differentiation in colorectal cancer and its biological features need further studies.
    Title: Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of WD repeat and SOCS box containing 2 (WSB2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC10210

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
WD repeat and SOCS box-containing protein 2
Names
CS box-containing WD protein
WSB-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278557.1 → NP_001265486.1  WD repeat and SOCS box-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001265486.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC131159, AF229181, AK295555, CA443120
    Consensus CDS
    CCDS61252.1
    UniProtKB/Swiss-Prot
    Q9NYS7
    Related
    ENSP00000409131.2, ENST00000441406.6
    Conserved Domains (4) summary
    COG2319
    Location:47 → 384
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:138 → 377
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd03733
    Location:381 → 419
    SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
    sd00039
    Location:174 → 212
    7WD40; WD40 repeat [structural motif]

  2. NM_001278558.2 → NP_001265487.1  WD repeat and SOCS box-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001265487.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks two internal exons compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC131159, AF229181, AK298513, CA443120, DA772463
    Consensus CDS
    CCDS61251.1
    UniProtKB/TrEMBL
    B4DFS1
    Related
    ENSP00000444431.1, ENST00000544233.5
    Conserved Domains (3) summary
    cd03733
    Location:154 → 192
    SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
    sd00039
    Location:32 → 68
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:1 → 150
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_018639.5 → NP_061109.1  WD repeat and SOCS box-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_061109.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC131159, AF229181, CA443120, DA772463
    Consensus CDS
    CCDS9186.1
    UniProtKB/Swiss-Prot
    B4DIE6, B4DPV6, Q9NRX9, Q9NYS7
    Related
    ENSP00000319474.3, ENST00000315436.8
    Conserved Domains (3) summary
    cd00200
    Location:121 → 360
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd03733
    Location:364 → 402
    SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
    sd00039
    Location:157 → 195
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    118032687..118062174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    118019987..118049474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NYS7.1 GenPept UniProtKB/Swiss-Prot:Q9NYS7

Gene LinkOut

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