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PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 [ Homo sapiens (human) ]

Gene ID: 55824, updated on 5-Mar-2024

Summary

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Official Symbol
PAG1provided by HGNC
Official Full Name
phosphoprotein membrane anchor with glycosphingolipid microdomains 1provided by HGNC
Primary source
HGNC:HGNC:30043
See related
Ensembl:ENSG00000076641 MIM:605767; AllianceGenome:HGNC:30043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBP; PAG
Summary
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 8.7), placenta (RPKM 8.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
8q21.13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (80967810..81112068, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (81399402..81543674, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (81880045..82024303, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 704 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:81734976-81736175 Neighboring gene high mobility group box 1 pseudogene 41 Neighboring gene MPRA-validated peak7088 silencer Neighboring gene uncharacterized LOC107986894 Neighboring gene HNF4 motif-containing MPRA enhancer 108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27570 Neighboring gene uncharacterized LOC124901967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19326 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27578 Neighboring gene uncharacterized LOC105375924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19327 Neighboring gene NANOG hESC enhancer GRCh37_chr8:82108601-82109175 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27580 Neighboring gene ubiquitin conjugating enzyme E2 H pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation. Foltz L, et al. Mol Biol Cell, 2020 Sep 15. PMID 32726167, Free PMC Article
  2. Upregulation of PAG1/Cbp contributes to adipose-derived mesenchymal stem cells promoted tumor progression and chemoresistance in breast cancer. Lu Y, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29079189
  3. Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma. Agarwal S, et al. Oncotarget, 2016 Apr 26. PMID 26993602, Free PMC Article
  4. Long-Range Modulation of PAG1 Expression by 8q21 Allergy Risk Variants. Vicente CT, et al. Am J Hum Genet, 2015 Aug 6. PMID 26211970, Free PMC Article
  5. [Phenotypic changes and apoptosis of Jurkat cells induced by over-expression of C-Src kinase-binding protein]. Gao M, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2015 Jun. PMID 26062415

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) in regulating the progression of oral squamous cell carcinoma.
    Title: The role of phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) in regulating the progression of oral squamous cell carcinoma.
  2. Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells.
    Title: Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells.
  3. PAG1 stimulates proliferation and metastasis of nasopharyngeal carcinoma through downregulating PTEN.
    Title: PAG1 stimulates proliferation and metastasis of nasopharyngeal carcinoma through downregulating PTEN.
  4. PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation.
    Title: PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation.
  5. PAG1 conferred inherent radioresistance by activating STAT3.
    Title: PAG1 promotes the inherent radioresistance of laryngeal cancer cells via activation of STAT3.
  6. Low PAG1 expression is associated neuroblastoma.
    Title: Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma.
  7. Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src and AKT/mTOR pathways.
    Title: Upregulation of PAG1/Cbp contributes to adipose-derived mesenchymal stem cells promoted tumor progression and chemoresistance in breast cancer.
  8. Up-regulated expression of CBP in Jurkat cells could reduce cell homogeneity and promote cell apoptosis
    Title: [Phenotypic changes and apoptosis of Jurkat cells induced by over-expression of C-Src kinase-binding protein].
  9. No association Pag1 mutation with patient with Schizophrenia.
    Title: Sequencing and expression analyses of the synaptic lipid raft adapter gene PAG1 in schizophrenia.
  10. The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation and have a pro-inflammatory effect.
    Title: Long-Range Modulation of PAG1 Expression by 8q21 Allergy Risk Variants.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37858, MGC138364

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH2 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH2 domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Names
Csk-binding protein
phosphoprotein associated with glycosphingolipid microdomains 1
transmembrane adapter protein PAG
transmembrane adaptor protein PAG
transmembrane phosphoprotein Cbp

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018440.4 → NP_060910.3  phosphoprotein associated with glycosphingolipid-enriched microdomains 1

    See identical proteins and their annotated locations for NP_060910.3

    Status: REVIEWED

    Source sequence(s)
    AA766638, AC012533, AK000680, BC090931, BX426120, CB960651
    Consensus CDS
    CCDS6227.1
    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0
    Related
    ENSP00000220597.3, ENST00000220597.4
    Conserved Domains (1) summary
    pfam15347
    Location:2 → 432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    80967810..81112068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421993.1 → XP_047277949.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  2. XM_047421992.1 → XP_047277948.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  3. XM_047421991.1 → XP_047277947.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  4. XM_047421990.1 → XP_047277946.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  5. XM_047421989.1 → XP_047277945.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  6. XM_047421985.1 → XP_047277941.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  7. XM_047421986.1 → XP_047277942.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  8. XM_047421988.1 → XP_047277944.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  9. XM_047421987.1 → XP_047277943.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  10. XM_047421984.1 → XP_047277940.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  11. XM_047421981.1 → XP_047277937.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  12. XM_047421983.1 → XP_047277939.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  13. XM_047421980.1 → XP_047277936.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  14. XM_017013642.3 → XP_016869131.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0
    Conserved Domains (1) summary
    pfam15347
    Location:2 → 432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched

  15. XM_047421982.1 → XP_047277938.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  16. XM_017013643.2 → XP_016869132.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0
    Conserved Domains (1) summary
    pfam15347
    Location:2 → 432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched

  17. XM_047421994.1 → XP_047277950.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X2

RNA

  1. XR_007060746.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    81399402..81543674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360841.1 → XP_054216816.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  2. XM_054360838.1 → XP_054216813.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  3. XM_054360837.1 → XP_054216812.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  4. XM_054360836.1 → XP_054216811.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  5. XM_054360835.1 → XP_054216810.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  6. XM_054360834.1 → XP_054216809.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  7. XM_054360839.1 → XP_054216814.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  8. XM_054360840.1 → XP_054216815.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K1A3, Q2M1Z9, Q5BKU4, Q9NWQ8, Q9NYK0

  9. XM_054360842.1 → XP_054216817.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X2

RNA

  1. XR_008487864.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007549.1: Suppressed sequence

    Description
    NM_001007549.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NWQ8.2 GenPept UniProtKB/Swiss-Prot:Q9NWQ8

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