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TSNAXIP1 translin associated factor X interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 55815, updated on 3-Apr-2024

Summary

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Official Symbol
TSNAXIP1provided by HGNC
Official Full Name
translin associated factor X interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:18586
See related
Ensembl:ENSG00000102904 MIM:607720; AllianceGenome:HGNC:18586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TXI1
Summary
Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 14.4), brain (RPKM 1.0) and 3 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
16q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67806889..67828068)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73601912..73623850)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67840792..67861971)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67710969-67711925 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67711926-67712881 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:67717419-67718618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10980 Neighboring gene Gfo/Idh/MocA-like oxidoreductase domain containing 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:67743233-67744011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67744012-67744789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7623 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7624 Neighboring gene RAN binding protein 10 Neighboring gene Sharpr-MPRA regulatory region 12647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10984 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67839586-67840206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67840207-67840826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7626 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67851021-67851203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67859393-67860253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67876439-67877185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7629 Neighboring gene centromere protein T Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10991 Neighboring gene THAP domain containing 11 Neighboring gene nuclear transport factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lack of association between translin-associated factor X gene (TSNAX) and methamphetamine dependence in the Japanese population. Kishi T, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2011 Aug 15. PMID 21683752
  2. Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X. Bray JD, et al. Genomics, 2002 Jun. PMID 12036294
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Katsogiannou M, et al. Mol Cell Proteomics, 2014 Dec. PMID 25277244, Free PMC Article
  4. Biological insights from 108 schizophrenia-associated genetic loci. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature, 2014 Jul 24. PMID 25056061, Free PMC Article
  5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC111443

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
translin-associated factor X-interacting protein 1
Names
trax-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054717.1 RefSeqGene

    Range
    5317..26496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001288990.3 → NP_001275919.1  translin-associated factor X-interacting protein 1 isoform a

    See identical proteins and their annotated locations for NP_001275919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK301920, BC062628, BU607826
    Consensus CDS
    CCDS73903.1
    UniProtKB/TrEMBL
    B4DXD0, B4E1H3
    Related
    ENSP00000457241.1, ENST00000561639.6
    Conserved Domains (1) summary
    pfam15739
    Location:108 → 211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  2. NM_001288991.3 → NP_001275920.1  translin-associated factor X-interacting protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    AK303841, BC062628, BC111018, BU607826
    Consensus CDS
    CCDS73904.1
    UniProtKB/TrEMBL
    B4E1H3, E7ENJ7
    Related
    ENSP00000411472.3, ENST00000415766.7
    Conserved Domains (1) summary
    pfam15739
    Location:92 → 142
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  3. NM_001288992.3 → NP_001275921.1  translin-associated factor X-interacting protein 1 isoform d

    See identical proteins and their annotated locations for NP_001275921.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 4, 5, and 6 encode the same isoform.
    Source sequence(s)
    BC062628, BU607826

  4. NM_001288993.3 → NP_001275922.1  translin-associated factor X-interacting protein 1 isoform d

    See identical proteins and their annotated locations for NP_001275922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 4, 5, and 6 encode the same isoform.
    Source sequence(s)
    AF132730, BC062628, BU607826
    Related
    ENST00000487120.5

  5. NM_001288994.3 → NP_001275923.1  translin-associated factor X-interacting protein 1 isoform d

    See identical proteins and their annotated locations for NP_001275923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 4, 5, and 6 encode the same isoform.
    Source sequence(s)
    BC050693, BC062628, BU607826
    Related
    ENST00000565339.5

  6. NM_001351158.2 → NP_001338087.1  translin-associated factor X-interacting protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, initiates translation at an alternate start codon, lacks three exons, and uses an alternate in-frame splice site in its 5' coding region compared to variant 1. The encoded isoform (e) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC040162, BU607826
    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    pfam15739
    Location:73 → 123
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  7. NM_018430.4 → NP_060900.2  translin-associated factor X-interacting protein 1 isoform b

    See identical proteins and their annotated locations for NP_060900.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    BC062628, BC111018, BU607634
    Consensus CDS
    CCDS10846.2
    UniProtKB/Swiss-Prot
    Q2TAA8, Q9P105
    UniProtKB/TrEMBL
    B4E1H3
    Related
    ENSP00000373485.3, ENST00000388833.7
    Conserved Domains (2) summary
    pfam15739
    Location:54 → 157
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
    cl25732
    Location:48 → 316
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67806889..67828068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523230.3 → XP_011521532.1  translin-associated factor X-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    pfam15739
    Location:108 → 211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  2. XM_011523232.3 → XP_011521534.1  translin-associated factor X-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    pfam15739
    Location:108 → 211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  3. XM_011523233.3 → XP_011521535.1  translin-associated factor X-interacting protein 1 isoform X4

    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    pfam15739
    Location:108 → 211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  4. XM_011523231.3 → XP_011521533.1  translin-associated factor X-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    pfam15739
    Location:108 → 211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  5. XM_011523234.3 → XP_011521536.1  translin-associated factor X-interacting protein 1 isoform X5

    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    pfam15739
    Location:108 → 211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  6. XM_005256049.5 → XP_005256106.1  translin-associated factor X-interacting protein 1 isoform X6

    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    pfam15739
    Location:108 → 211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  7. XM_011523239.2 → XP_011521541.1  translin-associated factor X-interacting protein 1 isoform X12

  8. XM_024450351.2 → XP_024306119.1  translin-associated factor X-interacting protein 1 isoform X16

  9. XM_011523236.4 → XP_011521538.1  translin-associated factor X-interacting protein 1 isoform X7

    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    pfam15739
    Location:92 → 142
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  10. XM_017023445.3 → XP_016878934.1  translin-associated factor X-interacting protein 1 isoform X8

    UniProtKB/TrEMBL
    B4E1H3

  11. XM_017023447.3 → XP_016878936.1  translin-associated factor X-interacting protein 1 isoform X14

    UniProtKB/TrEMBL
    B4E1H3

  12. XM_017023449.3 → XP_016878938.1  translin-associated factor X-interacting protein 1 isoform X17

    UniProtKB/TrEMBL
    B4E1H3

  13. XM_011523237.3 → XP_011521539.1  translin-associated factor X-interacting protein 1 isoform X9

    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    pfam15739
    Location:44 → 131
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  14. XM_011523238.2 → XP_011521540.1  translin-associated factor X-interacting protein 1 isoform X10

    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    pfam15739
    Location:73 → 123
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

  15. XM_024450350.2 → XP_024306118.1  translin-associated factor X-interacting protein 1 isoform X11

    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    cl25732
    Location:46 → 282
    SMC_N; RecF/RecN/SMC N terminal domain

  16. XM_017023446.2 → XP_016878935.1  translin-associated factor X-interacting protein 1 isoform X13

    UniProtKB/TrEMBL
    B4E1H3

  17. XM_017023448.2 → XP_016878937.1  translin-associated factor X-interacting protein 1 isoform X15

    UniProtKB/TrEMBL
    B4E1H3
    Conserved Domains (1) summary
    pfam15739
    Location:73 → 123
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    73601912..73623850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313473.1 → XP_054169448.1  translin-associated factor X-interacting protein 1 isoform X1

  2. XM_054313475.1 → XP_054169450.1  translin-associated factor X-interacting protein 1 isoform X3

  3. XM_054313476.1 → XP_054169451.1  translin-associated factor X-interacting protein 1 isoform X4

  4. XM_054313474.1 → XP_054169449.1  translin-associated factor X-interacting protein 1 isoform X2

  5. XM_054313477.1 → XP_054169452.1  translin-associated factor X-interacting protein 1 isoform X5

  6. XM_054313478.1 → XP_054169453.1  translin-associated factor X-interacting protein 1 isoform X6

  7. XM_054313484.1 → XP_054169459.1  translin-associated factor X-interacting protein 1 isoform X12

  8. XM_054313488.1 → XP_054169463.1  translin-associated factor X-interacting protein 1 isoform X16

  9. XM_054313479.1 → XP_054169454.1  translin-associated factor X-interacting protein 1 isoform X7

  10. XM_054313480.1 → XP_054169455.1  translin-associated factor X-interacting protein 1 isoform X8

  11. XM_054313486.1 → XP_054169461.1  translin-associated factor X-interacting protein 1 isoform X14

  12. XM_054313489.1 → XP_054169464.1  translin-associated factor X-interacting protein 1 isoform X17

  13. XM_054313481.1 → XP_054169456.1  translin-associated factor X-interacting protein 1 isoform X9

  14. XM_054313482.1 → XP_054169457.1  translin-associated factor X-interacting protein 1 isoform X10

  15. XM_054313483.1 → XP_054169458.1  translin-associated factor X-interacting protein 1 isoform X11

  16. XM_054313485.1 → XP_054169460.1  translin-associated factor X-interacting protein 1 isoform X13

  17. XM_054313487.1 → XP_054169462.1  translin-associated factor X-interacting protein 1 isoform X15

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TAA8.1 GenPept UniProtKB/Swiss-Prot:Q2TAA8

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