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ADCY10 adenylate cyclase 10 [ Homo sapiens (human) ]

Gene ID: 55811, updated on 5-Mar-2024

Summary

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Official Symbol
ADCY10provided by HGNC
Official Full Name
adenylate cyclase 10provided by HGNC
Primary source
HGNC:HGNC:21285
See related
Ensembl:ENSG00000143199 MIM:605205; AllianceGenome:HGNC:21285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAC; HCA2; SACI; Sacy; hsAC; HEL-S-7a
Summary
The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]
Expression
Restricted expression toward testis (RPKM 5.6) See more
Orthologs
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Genomic context

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See ADCY10 in Genome Data Viewer
Location:
1q24.2
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (167809386..167914134, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (167160872..167265599, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167778623..167883372, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:167688821-167689320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:167691547-167692047 Neighboring gene tRNA-Pro (anticodon AGG) 2-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167697263-167697762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2053 Neighboring gene myelin protein zero like 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:167739237-167739808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167740743-167741244 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:167761820-167761968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1538 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:167830579-167831095 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:167831096-167831613 Neighboring gene Sharpr-MPRA regulatory region 4419 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:167882400-167883076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:167883077-167883753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1541 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:167956130-167957329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2056 Neighboring gene microRNA 1255b-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Soluble adenylyl cyclase regulates the cytosolic NADH/NAD(+) redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation. Chang JC, et al. Biochim Biophys Acta Bioenerg, 2021 Apr 1. PMID 33412125
  2. ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria. Akbari A, et al. Hum Reprod, 2019 Jun 4. PMID 31119281
  3. Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. Kleinboelting S, et al. J Biol Chem, 2016 Apr 29. PMID 26961873, Free PMC Article
  4. Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain. De Rasmo D, et al. Biochim Biophys Acta, 2015 Jan. PMID 25409931
  5. Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes-implications for cyclase catalysis and evolution. Kleinboelting S, et al. FEBS J, 2014 Sep. PMID 25040695

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two novel heterozygous ADCY10 variants identified in Chinese pediatric patients with absorptive hypercalciuria: case report and literature review.
    Title: Two novel heterozygous ADCY10 variants identified in Chinese pediatric patients with absorptive hypercalciuria: case report and literature review.
  2. Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma.
    Title: Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma.
  3. Soluble adenylyl cyclase regulates the cytosolic NADH/NAD(+) redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation.
    Title: Soluble adenylyl cyclase regulates the cytosolic NADH/NAD(+) redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation.
  4. Soluble adenylyl cyclase links Ca(2+) entry to Ca(2+)/cAMP-response element binding protein (CREB) activation in vascular smooth muscle.
    Title: Soluble adenylyl cyclase links Ca(2+) entry to Ca(2+)/cAMP-response element binding protein (CREB) activation in vascular smooth muscle.
  5. Study provides the first report of a homozygous frameshift variation (c.1205_1206del; dbSNP rs779944215) in the exonic region of ADCY10 associated with recessive asthenozoospermia, in an inbred family from Iran. Noticeably, all relatives who were heterozygous or homozygous for the variant had a history of developing calcium kidney stones, confirming the association with absorptive hypercalciuria (OMIM#143870).
    Title: ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria.
  6. the higher level of cyclic AMP observed in Parkin-mutant fibroblasts can contribute to a higher level of activity/expression by soluble adenylyl cyclase.
    Title: Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in Parkin-Mutant Fibroblasts.
  7. results thus provide 1) novel insights into the communication between allosteric regulatory and active sites, 2) a novel mechanism for sAC inhibition, and 3) pharmacological compounds targeting this allosteric site and utilizing this mode of inhibition.
    Title: Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.
  8. The data support an important role for prostaglandin activation of sAC and PKA in H2O2-induced barrier disruption.
    Title: Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes in epithelial barrier function.
  9. Evaluation of soluble adenylyl cyclase expression using R21 antibody is a useful diagnostic adjunct in the evaluation of margins of LM during slow Mohs surgery.
    Title: Soluble adenylyl cyclase antibody (R21) as a diagnostic adjunct in the evaluation of lentigo maligna margins during slow Mohs surgery.
  10. shows that in fibroblast cultures inhibition by KH7 of production in the mitochondrial matrix by soluble adenylyl cyclase
    Title: Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Familial idiopathic hypercalciuria
MedGen: C0342639 OMIM: 143870 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables bicarbonate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cellular response to inorganic substance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epithelial cilium movement involved in extracellular fluid movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial ATP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cardiac muscle cell contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of reactive oxygen species biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection extension IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection retraction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of glycogen catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of reactive oxygen species biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane repolarization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in astrocyte end-foot IEA
Inferred from Electronic Annotation
more info
  
located_in basal part of cell IEA
Inferred from Electronic Annotation
more info
  
located_in central region of growth cone IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenylate cyclase type 10
Names
3',5'-cyclic AMP synthetase
AH-related protein
ATP pyrophosphate-lyase
adenylate cyclase 10, soluble
epididymis secretory sperm binding protein Li 7a
germ cell soluble adenylyl cyclase
testicular soluble adenylyl cyclase (SAC)
NP_001161221.1
NP_001284701.1
NP_060887.2
XP_005245387.1
XP_006711512.1
XP_011508062.1
XP_011508064.1
XP_011508065.1
XP_011508068.1
XP_016857267.1
XP_047281109.1
XP_054193620.1
XP_054193621.1
XP_054193622.1
XP_054193623.1
XP_054193624.1
XP_054193625.1
XP_054193626.1
XP_054193627.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016139.2 RefSeqGene

    Range
    5000..109748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001167749.3 → NP_001161221.1  adenylate cyclase type 10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AF299350, AK302884, BC117366, DB063660, Z99943
    Consensus CDS
    CCDS53426.1
    UniProtKB/Swiss-Prot
    Q96PN6
    Related
    ENSP00000441992.1, ENST00000545172.5
    Conserved Domains (1) summary
    cd07302
    Location:139 → 308
    CHD; cyclase homology domain

  2. NM_001297772.2 → NP_001284701.1  adenylate cyclase type 10 isoform 3

    See identical proteins and their annotated locations for NP_001284701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF299350, AF331033, AK302884, BC117366, DB063660, Z99943
    Consensus CDS
    CCDS72977.1
    UniProtKB/Swiss-Prot
    Q96PN6
    Related
    ENSP00000356822.1, ENST00000367848.1
    Conserved Domains (2) summary
    cd07302
    Location:200 → 369
    CHD; cyclase homology domain
    cl11967
    Location:6 → 122
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

  3. NM_018417.6 → NP_060887.2  adenylate cyclase type 10 isoform 1

    See identical proteins and their annotated locations for NP_060887.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF299350, AK302884, BC117366, DB063660, Z99943
    Consensus CDS
    CCDS1265.1
    UniProtKB/Swiss-Prot
    B4DZF0, F5GWS5, O95558, Q5R329, Q5R330, Q8WXV4, Q96PN6, Q9NNX0
    UniProtKB/TrEMBL
    A0A0K0K1J8
    Related
    ENSP00000356825.4, ENST00000367851.9
    Conserved Domains (2) summary
    cd07302
    Location:40 → 214
    CHD; cyclase homology domain
    COG2114
    Location:42 → 197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    167809386..167914134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509762.4 → XP_011508064.1  adenylate cyclase type 10 isoform X2

    Conserved Domains (3) summary
    cd07302
    Location:244 → 413
    CHD; cyclase homology domain
    COG2114
    Location:42 → 130
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    cl11967
    Location:43 → 142
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

  2. XM_011509763.4 → XP_011508065.1  adenylate cyclase type 10 isoform X3

    Conserved Domains (2) summary
    cd07302
    Location:40 → 214
    CHD; cyclase homology domain
    COG2114
    Location:42 → 197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]

  3. XM_006711449.5 → XP_006711512.1  adenylate cyclase type 10 isoform X4

    Conserved Domains (2) summary
    cd07302
    Location:40 → 214
    CHD; cyclase homology domain
    COG2114
    Location:42 → 197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]

  4. XM_011509760.4 → XP_011508062.1  adenylate cyclase type 10 isoform X1

    See identical proteins and their annotated locations for XP_011508062.1

    UniProtKB/Swiss-Prot
    B4DZF0, F5GWS5, O95558, Q5R329, Q5R330, Q8WXV4, Q96PN6, Q9NNX0
    UniProtKB/TrEMBL
    A0A0K0K1J8
    Conserved Domains (2) summary
    cd07302
    Location:40 → 214
    CHD; cyclase homology domain
    COG2114
    Location:42 → 197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]

  5. XM_047425153.1 → XP_047281109.1  adenylate cyclase type 10 isoform X5

  6. XM_005245330.6 → XP_005245387.1  adenylate cyclase type 10 isoform X7

    Conserved Domains (3) summary
    cd07302
    Location:40 → 214
    CHD; cyclase homology domain
    COG2114
    Location:42 → 197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    pfam13191
    Location:485 → 669
    AAA_16; AAA ATPase domain

  7. XM_017001778.3 → XP_016857267.1  adenylate cyclase type 10 isoform X6

  8. XM_011509766.4 → XP_011508068.1  adenylate cyclase type 10 isoform X8

    Conserved Domains (3) summary
    cd07302
    Location:40 → 214
    CHD; cyclase homology domain
    COG2114
    Location:42 → 197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    pfam13191
    Location:485 → 669
    AAA_16; AAA ATPase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    167160872..167265599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337646.1 → XP_054193621.1  adenylate cyclase type 10 isoform X2

  2. XM_054337647.1 → XP_054193622.1  adenylate cyclase type 10 isoform X3

  3. XM_054337648.1 → XP_054193623.1  adenylate cyclase type 10 isoform X4

  4. XM_054337645.1 → XP_054193620.1  adenylate cyclase type 10 isoform X1

  5. XM_054337649.1 → XP_054193624.1  adenylate cyclase type 10 isoform X5

  6. XM_054337651.1 → XP_054193626.1  adenylate cyclase type 10 isoform X7

  7. XM_054337650.1 → XP_054193625.1  adenylate cyclase type 10 isoform X6

  8. XM_054337652.1 → XP_054193627.1  adenylate cyclase type 10 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PN6.3 GenPept UniProtKB/Swiss-Prot:Q96PN6

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