U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RCOR3 REST corepressor 3 [ Homo sapiens (human) ]

Gene ID: 55758, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
RCOR3provided by HGNC
Official Full Name
REST corepressor 3provided by HGNC
Primary source
HGNC:HGNC:25594
See related
Ensembl:ENSG00000117625 MIM:620464; AllianceGenome:HGNC:25594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable enzyme binding activity and transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 13.7), thyroid (RPKM 11.6) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q32.2-q32.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (211259366..211316385)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (210504931..210561986)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211432708..211489727)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PRELID1 pseudogene 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:211402251-211402447 Neighboring gene uncharacterized LOC105372902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2482 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:211431921-211432422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:211432925-211433424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211498879-211499380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2484 Neighboring gene TNF receptor associated factor 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1785 Neighboring gene uncharacterized LOC124904504 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:211550792-211551568

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Involvement of REST corepressor 3 in prognosis of human hepatitis B. Xue JH, et al. Acta Pharmacol Sin, 2011 Aug. PMID 21765449, Free PMC Article
  2. Control of developmentally primed erythroid genes by combinatorial co-repressor actions. Stadhouders R, et al. Nat Commun, 2015 Nov 23. PMID 26593974, Free PMC Article
  3. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Bantscheff M, et al. Nat Biotechnol, 2011 Mar. PMID 21258344
  4. Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis. Maitland MER, et al. FASEB J, 2021 Sep. PMID 34383978, Free PMC Article
  5. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. Ouyang J, et al. Mol Cell, 2009 Apr 24. PMID 19394292, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ10876, FLJ16298

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
REST corepressor 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136223.3 → NP_001129695.1  REST corepressor 3 isoform a

    See identical proteins and their annotated locations for NP_001129695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK302664, AL590101, BU689437, HY024910
    Consensus CDS
    CCDS44312.1
    UniProtKB/Swiss-Prot
    Q9P2K3
    Related
    ENSP00000413929.2, ENST00000419091.7
    Conserved Domains (3) summary
    pfam00249
    Location:347 → 390
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:59 → 110
    ELM2; ELM2 domain
    cl21498
    Location:146 → 190
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  2. NM_001136224.4 → NP_001129696.2  REST corepressor 3 isoform b

    See identical proteins and their annotated locations for NP_001129696.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 3' coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL590101, BC031608, BU689437, DC387352, HY024910
    Consensus CDS
    CCDS44313.1
    UniProtKB/Swiss-Prot
    Q9P2K3
    Related
    ENSP00000355973.4, ENST00000367006.8
    Conserved Domains (2) summary
    pfam01448
    Location:59 → 110
    ELM2; ELM2 domain
    cl21498
    Location:146 → 190
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  3. NM_001136225.3 → NP_001129697.1  REST corepressor 3 isoform c

    See identical proteins and their annotated locations for NP_001129697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA831517, AK131312, HY024910
    Consensus CDS
    CCDS44314.1
    UniProtKB/Swiss-Prot
    Q9P2K3
    Related
    ENSP00000398558.2, ENST00000452621.6
    Conserved Domains (3) summary
    pfam00249
    Location:347 → 390
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:59 → 110
    ELM2; ELM2 domain
    cl21498
    Location:146 → 190
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  4. NM_001350069.2 → NP_001336998.1  REST corepressor 3 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (e) has the same N- and C-termini, but is longer than isoform a.
    Source sequence(s)
    AK302664, AL590101, BU689437, DA925839, HY024910
    Conserved Domains (3) summary
    pfam00249
    Location:379 → 422
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:59 → 142
    ELM2; ELM2 domain
    cl21498
    Location:178 → 222
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  5. NM_001350070.2 → NP_001336999.1  REST corepressor 3 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate exon in its 5' UTR, resulting in the use of a downstream start codon compared to variant 1. The resulting isoform (f) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AK302664, AL590101, AL611964, BU689437, DB164963, HY024910
    Conserved Domains (2) summary
    pfam00249
    Location:226 → 269
    Myb_DNA-binding; Myb-like DNA-binding domain
    cl21498
    Location:25 → 69
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  6. NM_018254.5 → NP_060724.1  REST corepressor 3 isoform d

    See identical proteins and their annotated locations for NP_060724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AK001738, AL590101, BU689437, DA478986
    Consensus CDS
    CCDS31016.1
    UniProtKB/Swiss-Prot
    B3KYA2, B4DYY7, Q5VT47, Q7L9I5, Q8N5U3, Q9NV83, Q9P2K3
    Related
    ENSP00000355972.4, ENST00000367005.8
    Conserved Domains (3) summary
    pfam00249
    Location:289 → 332
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:1 → 52
    ELM2; ELM2 domain
    cl21498
    Location:88 → 132
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RNA

  1. NR_146432.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in its 5' terminal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD)
    Source sequence(s)
    AK302664, AL590101, BI051857, BU689437, DA334880, HY024910

  2. NR_146433.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK302664, AL590101, BI051857, BQ218032, BU689437, DC387352, HY024910

  3. NR_146434.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains an alternate internal exon, and it 3' terminal exon extends past a splice site that is used in variant 1.. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA831517, AI380424, AK302664, BI051857, BP221223, BQ218032, DA224160, DC387352, HY024910

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    211259366..211316385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425046.1 → XP_047281002.1  REST corepressor 3 isoform X9

  2. XM_005273191.6 → XP_005273248.1  REST corepressor 3 isoform X1

    Conserved Domains (3) summary
    pfam00249
    Location:348 → 391
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:60 → 111
    ELM2; ELM2 domain
    cl21498
    Location:147 → 191
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  3. XM_006711442.3 → XP_006711505.1  REST corepressor 3 isoform X4

    Conserved Domains (3) summary
    smart00717
    Location:146 → 192
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:60 → 111
    ELM2; ELM2 domain
    cl21498
    Location:147 → 191
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  4. XM_011509748.3 → XP_011508050.1  REST corepressor 3 isoform X2

    Conserved Domains (4) summary
    COG5259
    Location:223 → 356
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam00249
    Location:322 → 365
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:60 → 111
    ELM2; ELM2 domain
    cl21498
    Location:147 → 191
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  5. XM_047425021.1 → XP_047280977.1  REST corepressor 3 isoform X6

  6. XM_017001761.3 → XP_016857250.1  REST corepressor 3 isoform X3

  7. XM_047425032.1 → XP_047280988.1  REST corepressor 3 isoform X7

  8. XM_047425043.1 → XP_047280999.1  REST corepressor 3 isoform X9

  9. XM_047425052.1 → XP_047281008.1  REST corepressor 3 isoform X11

  10. XM_047425053.1 → XP_047281009.1  REST corepressor 3 isoform X12

    Related
    ENSP00000432779.1, ENST00000528926.5

  11. XM_047425038.1 → XP_047280994.1  REST corepressor 3 isoform X8

  12. XM_047425051.1 → XP_047281007.1  REST corepressor 3 isoform X10

  13. XM_047425011.1 → XP_047280967.1  REST corepressor 3 isoform X5

RNA

  1. XR_007061956.1 RNA Sequence

  2. XR_007061955.1 RNA Sequence

  3. XR_007061958.1 RNA Sequence

  4. XR_007061957.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    210504931..210561986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337627.1 → XP_054193602.1  REST corepressor 3 isoform X9

  2. XM_054337618.1 → XP_054193593.1  REST corepressor 3 isoform X1

  3. XM_054337621.1 → XP_054193596.1  REST corepressor 3 isoform X4

  4. XM_054337619.1 → XP_054193594.1  REST corepressor 3 isoform X2

  5. XM_054337623.1 → XP_054193598.1  REST corepressor 3 isoform X6

  6. XM_054337620.1 → XP_054193595.1  REST corepressor 3 isoform X3

  7. XM_054337624.1 → XP_054193599.1  REST corepressor 3 isoform X7

  8. XM_054337626.1 → XP_054193601.1  REST corepressor 3 isoform X9

  9. XM_054337629.1 → XP_054193604.1  REST corepressor 3 isoform X11

  10. XM_054337630.1 → XP_054193605.1  REST corepressor 3 isoform X12

  11. XM_054337625.1 → XP_054193600.1  REST corepressor 3 isoform X8

  12. XM_054337628.1 → XP_054193603.1  REST corepressor 3 isoform X10

  13. XM_054337622.1 → XP_054193597.1  REST corepressor 3 isoform X5

RNA

  1. XR_008486105.1 RNA Sequence

  2. XR_008486104.1 RNA Sequence

  3. XR_008486107.1 RNA Sequence

  4. XR_008486106.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P2K3.2 GenPept UniProtKB/Swiss-Prot:Q9P2K3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous