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COA1 cytochrome c oxidase assembly factor 1 [ Homo sapiens (human) ]

Gene ID: 55744, updated on 11-Apr-2024

Summary

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Official Symbol
COA1provided by HGNC
Official Full Name
cytochrome c oxidase assembly factor 1provided by HGNC
Primary source
HGNC:HGNC:21868
See related
Ensembl:ENSG00000106603 MIM:614769; AllianceGenome:HGNC:21868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C7orf44; MITRAC15
Summary
Involved in mitochondrial cytochrome c oxidase assembly and mitochondrial respiratory chain complex I assembly. Located in cytosol and mitochondrion. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 6.8), appendix (RPKM 4.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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See COA1 in Genome Data Viewer
Location:
7p13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (43608457..43729523, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (43766512..43887637, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (43648056..43769122, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC102724903 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:43343825-43344325 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98938 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:43416277-43416776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:43507100-43507600 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:43593671-43594870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18123 Neighboring gene lncRNA upregulator of antiviral response interferon signaling Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:43616728-43617927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25911 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_99082 Neighboring gene Sharpr-MPRA regulatory region 11578 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:43688133-43688994 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43686409-43687270 Neighboring gene Sharpr-MPRA regulatory region 11574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25913 Neighboring gene serine/threonine kinase 17a Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43691438-43692181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18125 Neighboring gene NFE2L2 motif-containing MPRA enhancer 272 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:43768408-43769137 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:43769138-43769866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:43789665-43790184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:43789145-43789664 Neighboring gene uncharacterized LOC107986727 Neighboring gene CRISPRi-validated cis-regulatory element chr7.1855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25918 Neighboring gene Sharpr-MPRA regulatory region 4653 Neighboring gene biliverdin reductase A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18128 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_99190 Neighboring gene URGCP-MRPS24 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18129 Neighboring gene mitochondrial ribosomal protein S24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association of COA1 with Patellar Tendonitis: A Genome-wide Association Analysis. Kim SK, et al. Med Sci Sports Exerc, 2021 Nov 1. PMID 34081057
  2. MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex. Wang C, et al. EMBO Rep, 2020 Jan 7. PMID 31721420, Free PMC Article
  3. Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6. Fellenberg J, et al. Cancer Lett, 2016 Feb 1. PMID 26655997
  4. Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I. Formosa LE, et al. Cell Rep, 2020 Apr 21. PMID 32320651
  5. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. Mick DU, et al. Cell, 2012 Dec 21. PMID 23260140

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of COA1 with Patellar Tendonitis: A Genome-wide Association Analysis.
    Title: Association of COA1 with Patellar Tendonitis: A Genome-wide Association Analysis.
  2. MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex.
    Title: MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex.
  3. Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.
    Title: Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.
  4. Encodes a mitochondrial protein
    Title: Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
  5. Human ortholog of fungal COA1 (Cytochrome Oxidase Assembly 1)
    Title: Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10803

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
cytochrome c oxidase assembly factor 1 homolog
Names
cytochrome c oxidase assembly protein 1 homolog
mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321197.2 → NP_001308126.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 4-6, 16-19, and 27-36, encodes isoform a.
    Source sequence(s)
    AC005189, AK021905, BP373150, BP377872
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Related
    ENSP00000312100.6, ENST00000310564.10
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  2. NM_001321198.2 → NP_001308127.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 3, 5, 6, 16-19, and 27-36, encodes isoform a.
    Source sequence(s)
    AC005189, BG028456, BP377872
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Related
    ENSP00000413777.1, ENST00000446564.5
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  3. NM_001321199.2 → NP_001308128.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 3, 4, 6, 16-19, and 27-36, encodes isoform a.
    Source sequence(s)
    AC005189, BG334368, BP377872
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Related
    ENSP00000395586.1, ENST00000438444.5
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  4. NM_001321200.2 → NP_001308129.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 3-5, 16-19, and 27-36, encodes isoform a.
    Source sequence(s)
    AC005189, BG548154, BP377872
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  5. NM_001321201.2 → NP_001308130.1  cytochrome c oxidase assembly factor 1 homolog isoform b

    Status: VALIDATED

    Source sequence(s)
    AC005189, BP377872, BQ231567
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:6 → 122
    Coa1; Cytochrome oxidase complex assembly protein 1

  6. NM_001321202.2 → NP_001308131.1  cytochrome c oxidase assembly factor 1 homolog isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 9, 10, and 11, all encode the same isoform (c).
    Source sequence(s)
    AC005189, AK309315, BP377872
    Consensus CDS
    CCDS83177.1
    UniProtKB/TrEMBL
    F2Z2J3
    Related
    ENSP00000410365.1, ENST00000418140.5

  7. NM_001321203.2 → NP_001308132.1  cytochrome c oxidase assembly factor 1 homolog isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 8, 10, and 11, all encode the same isoform (c).
    Source sequence(s)
    AC005189, BP377872, DA107764
    Consensus CDS
    CCDS83177.1
    UniProtKB/TrEMBL
    F2Z2J3
    Related
    ENSP00000387433.1, ENST00000457939.1

  8. NM_001321204.2 → NP_001308133.1  cytochrome c oxidase assembly factor 1 homolog isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 8, 9, and 11, all encode the same isoform (c).
    Source sequence(s)
    AC005189, BP377872, DA099188
    Consensus CDS
    CCDS83177.1
    UniProtKB/TrEMBL
    F2Z2J3

  9. NM_001321205.2 → NP_001308134.1  cytochrome c oxidase assembly factor 1 homolog isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 8, 9, and 10, all encode the same isoform (c).
    Source sequence(s)
    AC005189, BP377872, DB003365
    Consensus CDS
    CCDS83177.1
    UniProtKB/TrEMBL
    F2Z2J3

  10. NM_001350924.2 → NP_001337853.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 1, 4-6, 17-19, and 27-36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  11. NM_001350925.2 → NP_001337854.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 1, 4-6, 16, 18, 19, and 27-36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  12. NM_001350926.2 → NP_001337855.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variants 1, 4-6, 16, 17, 19, and 27-36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  13. NM_001350927.2 → NP_001337856.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variants 1, 4-6, 16-18, and 27-36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  14. NM_001350928.2 → NP_001337857.1  cytochrome c oxidase assembly factor 1 homolog isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variant 37, encodes isoform d.
    Source sequence(s)
    AC005189
    Conserved Domains (1) summary
    pfam08695
    Location:40 → 128
    Coa1; Cytochrome oxidase complex assembly protein 1

  15. NM_001371307.1 → NP_001358236.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27), as well as variants 1, 3-6, 16-19, and 28-36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  16. NM_001371308.1 → NP_001358237.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28), as well as variants 1, 3-6, 16-19, 27, and 29-36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  17. NM_001371309.1 → NP_001358238.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (29), as well as variants 1, 3-6, 16-19, and 27, 28, and 30-36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  18. NM_001371310.1 → NP_001358239.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (30), as well as variants 1, 3-6, 16-19, 27-29, and 31-36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  19. NM_001371311.1 → NP_001358240.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (31), as well as variants 1, 3-6, 16-19, 27-30, and 32-36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  20. NM_001371312.1 → NP_001358241.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (32), as well as variants 1, 3-6, 16-19, 27-31, and 33-36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  21. NM_001371313.1 → NP_001358242.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (33), as well as variants 1, 3-6, 16-19, 27-32, and 34-36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  22. NM_001371314.1 → NP_001358243.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (34), as well as variants 1, 3-6, 16-19, 27-33, 35, and 36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  23. NM_001371315.1 → NP_001358244.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (35), as well as variants 1, 3-6, 16-19, 27-34, and 36, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  24. NM_001371316.1 → NP_001358245.1  cytochrome c oxidase assembly factor 1 homolog isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (36), as well as variants 1, 3-6, 16-19, and 27-35, encodes isoform a.
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

  25. NM_001371317.1 → NP_001358246.1  cytochrome c oxidase assembly factor 1 homolog isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (37), as well as variant 20, encodes isoform d.
    Source sequence(s)
    AC005189
    Conserved Domains (1) summary
    pfam08695
    Location:40 → 128
    Coa1; Cytochrome oxidase complex assembly protein 1

  26. NM_001371318.1 → NP_001358247.1  cytochrome c oxidase assembly factor 1 homolog isoform e

    Status: VALIDATED

    Source sequence(s)
    AC005189
    Conserved Domains (1) summary
    pfam08695
    Location:42 → 130
    Coa1; Cytochrome oxidase complex assembly protein 1

  27. NM_018224.4 → NP_060694.2  cytochrome c oxidase assembly factor 1 homolog isoform a

    See identical proteins and their annotated locations for NP_060694.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 3-6, 16-19, and 27-36 all encode the same isoform (a).
    Source sequence(s)
    AC005189
    Consensus CDS
    CCDS5471.1
    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2
    UniProtKB/TrEMBL
    B3KUH1
    Related
    ENSP00000223336.6, ENST00000223336.11
    Conserved Domains (1) summary
    pfam08695
    Location:18 → 134
    Coa1; Cytochrome oxidase complex assembly protein 1

RNA

  1. NR_135580.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645, AK023053, BP377872

  2. NR_135581.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645, AK293043, BP377872

  3. NR_135582.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645, BM918741, BP377872

  4. NR_135583.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645, AK001665, DA742258

  5. NR_146940.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645

  6. NR_146941.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645

  7. NR_146942.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645

  8. NR_146943.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645

  9. NR_146944.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645

  10. NR_146945.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645

  11. NR_163914.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, uses an alternate splice site in a 3' exon, and has an alternate terminal exon. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005189, AC093645

  12. NR_163915.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189

  13. NR_163916.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645

  14. NR_163917.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645

  15. NR_163918.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189, AC093645

  16. NR_163919.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005189

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    43608457..43729523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420603.1 → XP_047276559.1  cytochrome c oxidase assembly factor 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2

  2. XM_047420605.1 → XP_047276561.1  cytochrome c oxidase assembly factor 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2

  3. XM_047420604.1 → XP_047276560.1  cytochrome c oxidase assembly factor 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2

RNA

  1. XR_007060085.1 RNA Sequence

  2. XR_007060082.1 RNA Sequence

  3. XR_007060079.1 RNA Sequence

  4. XR_007060084.1 RNA Sequence

  5. XR_007060083.1 RNA Sequence

  6. XR_007060081.1 RNA Sequence

  7. XR_007060078.1 RNA Sequence

  8. XR_007060077.1 RNA Sequence

  9. XR_007060080.1 RNA Sequence

  10. XR_007060086.1 RNA Sequence

  11. XR_007060076.1 RNA Sequence

  12. XR_007060093.1 RNA Sequence

  13. XR_007060105.1 RNA Sequence

  14. XR_007060097.1 RNA Sequence

  15. XR_007060087.1 RNA Sequence

  16. XR_007060102.1 RNA Sequence

  17. XR_007060098.1 RNA Sequence

  18. XR_007060100.1 RNA Sequence

  19. XR_007060096.1 RNA Sequence

  20. XR_007060088.1 RNA Sequence

  21. XR_007060106.1 RNA Sequence

  22. XR_007060089.1 RNA Sequence

  23. XR_007060109.1 RNA Sequence

  24. XR_007060095.1 RNA Sequence

  25. XR_007060112.1 RNA Sequence

  26. XR_007060107.1 RNA Sequence

  27. XR_007060090.1 RNA Sequence

  28. XR_007060111.1 RNA Sequence

  29. XR_007060092.1 RNA Sequence

  30. XR_007060108.1 RNA Sequence

  31. XR_007060103.1 RNA Sequence

  32. XR_007060104.1 RNA Sequence

  33. XR_007060110.1 RNA Sequence

  34. XR_007060114.1 RNA Sequence

  35. XR_007060091.1 RNA Sequence

  36. XR_007060099.1 RNA Sequence

  37. XR_007060101.1 RNA Sequence

  38. XR_007060113.1 RNA Sequence

  39. XR_007060115.1 RNA Sequence

  40. XR_007060094.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    43766512..43887637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358632.1 → XP_054214607.1  cytochrome c oxidase assembly factor 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2

  2. XM_054358634.1 → XP_054214609.1  cytochrome c oxidase assembly factor 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2

  3. XM_054358633.1 → XP_054214608.1  cytochrome c oxidase assembly factor 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    A6NJU8, A8KAH8, Q9GZY4, Q9HAB7, Q9NVD2

RNA

  1. XR_008487674.1 RNA Sequence

  2. XR_008487671.1 RNA Sequence

  3. XR_008487668.1 RNA Sequence

  4. XR_008487673.1 RNA Sequence

  5. XR_008487672.1 RNA Sequence

  6. XR_008487670.1 RNA Sequence

  7. XR_008487666.1 RNA Sequence

  8. XR_008487665.1 RNA Sequence

  9. XR_008487669.1 RNA Sequence

  10. XR_008487675.1 RNA Sequence

  11. XR_008487664.1 RNA Sequence

  12. XR_008487682.1 RNA Sequence

  13. XR_008487694.1 RNA Sequence

  14. XR_008487685.1 RNA Sequence

  15. XR_008487676.1 RNA Sequence

  16. XR_008487691.1 RNA Sequence

  17. XR_008487687.1 RNA Sequence

  18. XR_008487689.1 RNA Sequence

  19. XR_008487686.1 RNA Sequence

  20. XR_008487677.1 RNA Sequence

  21. XR_008487695.1 RNA Sequence

  22. XR_008487678.1 RNA Sequence

  23. XR_008487698.1 RNA Sequence

  24. XR_008487684.1 RNA Sequence

  25. XR_008487701.1 RNA Sequence

  26. XR_008487696.1 RNA Sequence

  27. XR_008487679.1 RNA Sequence

  28. XR_008487700.1 RNA Sequence

  29. XR_008487681.1 RNA Sequence

  30. XR_008487697.1 RNA Sequence

  31. XR_008487692.1 RNA Sequence

  32. XR_008487693.1 RNA Sequence

  33. XR_008487699.1 RNA Sequence

  34. XR_008487680.1 RNA Sequence

  35. XR_008487688.1 RNA Sequence

  36. XR_008487690.1 RNA Sequence

  37. XR_008487702.1 RNA Sequence

  38. XR_008487703.1 RNA Sequence

  39. XR_008487683.1 RNA Sequence

  40. XR_008487667.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZY4.1 GenPept UniProtKB/Swiss-Prot:Q9GZY4

Gene LinkOut

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