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MAP7D1 MAP7 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55700, updated on 10-Dec-2024

Summary

Official Symbol
MAP7D1provided by HGNC
Official Full Name
MAP7 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25514
See related
Ensembl:ENSG00000116871 AllianceGenome:HGNC:25514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPRC1; PARCC1
Summary
Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in cytoplasm and spindle. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in fat (RPKM 43.2), brain (RPKM 39.0) and 24 other tissues See more
Orthologs
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Genomic context

See MAP7D1 in Genome Data Viewer
Location:
1p34.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (36156160..36180849)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (36019039..36043724)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36621761..36646450)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36563075-36563583 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 654 Neighboring gene collagen type VIII alpha 2 chain Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36579590-36580530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36580531-36581471 Neighboring gene MPRA-validated peak176 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:36614757-36615417 Neighboring gene trafficking protein particle complex subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36625977-36626754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 746 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:36638149-36639348 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 657 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36643121-36643768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36643769-36644414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36644415-36645060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36653458-36654156 Neighboring gene RNA, 7SL, cytoplasmic 131, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:36680691-36680811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 747 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:36689434-36689961 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:36689962-36690490 Neighboring gene thyroid hormone receptor associated protein 3 Neighboring gene ubiquitin conjugating enzyme E2 V2 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

General gene information

Clone Names

  • FLJ10350, FLJ39022, MGC117315

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm  
is_active_in microtubule cytoskeleton  
located_in spindle  

General protein information

Preferred Names
MAP7 domain-containing protein 1
Names
arginine/proline rich coiled-coil 1
arginine/proline-rich coiled-coil domain-containing protein 1
proline arginine rich coiled coil 1
proline/arginine-rich coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286365.2NP_001273294.1  MAP7 domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001273294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon and uses an alternate splice site compared to variant 1. The encoded isoform (2) ishorter than isofoem 1.
    Source sequence(s)
    AB033013, AC114484, AF218002
    Consensus CDS
    CCDS65493.1
    UniProtKB/Swiss-Prot
    Q3KQU3
    Related
    ENSP00000320228.4, ENST00000316156.8
    Conserved Domains (4) summary
    PTZ00121
    Location:130221
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:56143
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03247
    Location:278558
    PHA03247; large tegument protein UL36; Provisional
    pfam05672
    Location:551689
    MAP7; MAP7 (E-MAP-115) family
  2. NM_001286366.2NP_001273295.1  MAP7 domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001273295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple coding region differences but maintains the reading frame compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC114484, AF218002, AK096341
    Consensus CDS
    CCDS65492.1
    UniProtKB/Swiss-Prot
    Q3KQU3
    UniProtKB/TrEMBL
    B3KU03
    Related
    ENSP00000362243.4, ENST00000373150.8
    Conserved Domains (2) summary
    pfam05672
    Location:556697
    MAP7; MAP7 (E-MAP-115) family
    pfam14303
    Location:83209
    NAM-associated; No apical meristem-associated C-terminal domain
  3. NM_001388490.1NP_001375419.1  MAP7 domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC114484
    Consensus CDS
    CCDS90916.1
    UniProtKB/TrEMBL
    D3DPS3, Q6NX58
    Related
    ENSP00000507044.1, ENST00000474796.2
    Conserved Domains (4) summary
    PTZ00121
    Location:130221
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:315595
    PHA03247; large tegument protein UL36; Provisional
    PRK12323
    Location:2131
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam05672
    Location:588729
    MAP7; MAP7 (E-MAP-115) family
  4. NM_018067.5NP_060537.3  MAP7 domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_060537.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB033013, AC114484, AF218002, BC106053
    Consensus CDS
    CCDS30673.1
    UniProtKB/Swiss-Prot
    D3DPS4, Q3KQU3, Q7L8J5, Q8N905, Q8TAK0, Q9HBQ2, Q9NW29, Q9ULN3
    UniProtKB/TrEMBL
    Q6NX58
    Related
    ENSP00000362244.2, ENST00000373151.6
    Conserved Domains (2) summary
    pfam05672
    Location:588728
    MAP7; MAP7 (E-MAP-115) family
    pfam14303
    Location:83209
    NAM-associated; No apical meristem-associated C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    36156160..36180849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    36019039..36043724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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