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STAP2 signal transducing adaptor family member 2 [ Homo sapiens (human) ]

Gene ID: 55620, updated on 31-Mar-2024

Summary

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Official Symbol
STAP2provided by HGNC
Official Full Name
signal transducing adaptor family member 2provided by HGNC
Primary source
HGNC:HGNC:30430
See related
Ensembl:ENSG00000178078 MIM:607881; AllianceGenome:HGNC:30430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BKS
Summary
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 37.7), small intestine (RPKM 30.7) and 18 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4324043..4338827, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4307445..4326896, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4324040..4338824, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane and immunoglobulin domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4301847-4302392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9884 Neighboring gene fibronectin type III and SPRY domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4326526-4327507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13767 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4342611-4343342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4350305-4350806 Neighboring gene MPN domain containing Neighboring gene eukaryotic translation initiation factor 1 pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4365919-4366840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4368989-4369938 Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4369939-4370886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4372431-4373164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4373165-4373898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr19:4374633-4375365 and GRCh37_chr19:4375366-4376099 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4377567-4378299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13773 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:4386482-4386982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4389401-4390008 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4390009-4390615 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4390616-4391224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4394991-4395501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4399905-4400734

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells. Yamamoto T, et al. Biochem Biophys Res Commun, 2003 Jul 4. PMID 12810085
  2. Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases. Ichii M, et al. Exp Hematol, 2022 Jan. PMID 34780812
  3. STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells. Saitoh K, et al. Biochem Biophys Res Commun, 2017 Jun 17. PMID 28478037
  4. Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation. Muraoka D, et al. Oncotarget, 2017 May 9. PMID 28430604, Free PMC Article
  5. Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8. Sekine Y, et al. J Immunol, 2012 Jun 15. PMID 22611243

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation.
    Title: STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation.
  2. Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases.
    Title: Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases.
  3. These findings indicate an essential role for STAP2 in the generation of a high-quality memory CD8+ CTLs periphery, and suggest the therapeutic potential of STAP2 in cancer patients.
    Title: Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.
  4. High STAP2 expression is associated with prostate cancer.
    Title: STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization.
  5. The Pyk2/STAP-2 interaction is a novel mechanism to regulate SDF-1alpha-dependent T-cell chemotaxis.
    Title: STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells.
  6. STAP2 is upregulated in uterosacral ligaments in pelvic organ prolapse
    Title: Estrogen-related genome-based expression profiling study of uterosacral ligaments in women with pelvic organ prolapse.
  7. Our results demonstrate a critical contribution of STAP-2 in BCR-ABL activity.
    Title: STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.
  8. STAP-2 is a novel participant in the regulation of T cell apoptosis after stimulation
    Title: Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.
  9. Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.
    Title: Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20234

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
signal-transducing adaptor protein 2
Names
BRK substrate
breast tumor kinase substrate
brk kinase substrate

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013841.2 → NP_001013863.1  signal-transducing adaptor protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001013863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AC104521, BC000795, BF677969
    Consensus CDS
    CCDS45926.1
    UniProtKB/Swiss-Prot
    A6NKK3, Q9NXI2, Q9UGK3
    Related
    ENSP00000471052.1, ENST00000594605.6
    Conserved Domains (2) summary
    cd10404
    Location:151 → 247
    SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
    cd13268
    Location:9 → 136
    PH_Brdg1; BCR downstream signaling 1 Pleckstrin homology (PH) domain

  2. NM_017720.3 → NP_060190.2  signal-transducing adaptor protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008616, AC104521, AK000241, BF677969
    Consensus CDS
    CCDS12128.1
    UniProtKB/Swiss-Prot
    Q9UGK3
    Related
    ENSP00000468927.1, ENST00000600324.5
    Conserved Domains (2) summary
    cd10404
    Location:151 → 247
    SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
    cd13268
    Location:9 → 136
    PH_Brdg1; BCR downstream signaling 1 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4324043..4338827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528123.2 → XP_011526425.1  signal-transducing adaptor protein 2 isoform X1

    Conserved Domains (2) summary
    cd10404
    Location:151 → 247
    SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
    cd13268
    Location:9 → 136
    PH_Brdg1; BCR downstream signaling 1 Pleckstrin homology (PH) domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4307445..4326896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321404.1 → XP_054177379.1  signal-transducing adaptor protein 2 isoform X2

  2. XM_054321403.1 → XP_054177378.1  signal-transducing adaptor protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UGK3.2 GenPept UniProtKB/Swiss-Prot:Q9UGK3

Gene LinkOut

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