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ANKRD10 ankyrin repeat domain 10 [ Homo sapiens (human) ]

Gene ID: 55608, updated on 3-Apr-2024

Summary

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Official Symbol
ANKRD10provided by HGNC
Official Full Name
ankyrin repeat domain 10provided by HGNC
Primary source
HGNC:HGNC:20265
See related
Ensembl:ENSG00000088448 AllianceGenome:HGNC:20265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in spleen (RPKM 23.7), endometrium (RPKM 23.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
13q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (110878540..110915069, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (110108631..110144952, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (111530887..111567416, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111502835-111503338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111503339-111503840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111505979-111506517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5519 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:111521756-111522955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111525201-111526078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5520 Neighboring gene p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:111558775-111559276 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:111560595-111561212 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111566028-111566704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5522 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:111568056-111568730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111581847-111582346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8019 Neighboring gene uncharacterized LOC105370364 Neighboring gene poly(ADP-ribose) polymerase 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111608267-111609068 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:111609334-111610533 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:111617326-111618525 Neighboring gene long intergenic non-protein coding RNA 431

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  4. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20093, DKFZp686B07190

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286721.3 → NP_001273650.1  ankyrin repeat domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001273650.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and contains multiple differences in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL442128
    Consensus CDS
    CCDS66580.1
    UniProtKB/Swiss-Prot
    Q9NXR5
    Related
    ENSP00000312534.4, ENST00000310847.8
    Conserved Domains (3) summary
    sd00045
    Location:57 → 89
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:25 → 74
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:63 → 151
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_017664.4 → NP_060134.2  ankyrin repeat domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_060134.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK000100, AK094222, AL157875
    Consensus CDS
    CCDS9520.1
    UniProtKB/Swiss-Prot
    Q5VW12, Q9BV12, Q9NXR5
    Related
    ENSP00000267339.2, ENST00000267339.6
    Conserved Domains (5) summary
    COG0666
    Location:111 → 217
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:57 → 178
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:63 → 155
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:25 → 78
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:57 → 89
    ANK; ANK repeat [structural motif]

RNA

  1. NR_104586.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL442128

  2. NR_104587.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL157875, BX354283, DA961131

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    110878540..110915069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449380.2 → XP_024305148.1  ankyrin repeat domain-containing protein 10 isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:57 → 178
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:57 → 89
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:25 → 74
    Ank_4; Ankyrin repeats (many copies)

  2. XM_024449382.2 → XP_024305150.1  ankyrin repeat domain-containing protein 10 isoform X3

    Conserved Domains (2) summary
    cd00204
    Location:25 → 145
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:57 → 89
    ANK; ANK repeat [structural motif]

  3. XM_024449381.2 → XP_024305149.1  ankyrin repeat domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    Q8IUW1
    Related
    ENSP00000431927.1, ENST00000465753.1
    Conserved Domains (2) summary
    cd00204
    Location:25 → 145
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:57 → 89
    ANK; ANK repeat [structural motif]

  4. XM_024449383.2 → XP_024305151.1  ankyrin repeat domain-containing protein 10 isoform X4

    Conserved Domains (2) summary
    cd00204
    Location:25 → 145
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:57 → 89
    ANK; ANK repeat [structural motif]

RNA

  1. XR_007063690.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    110108631..110144952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374725.1 → XP_054230700.1  ankyrin repeat domain-containing protein 10 isoform X1

  2. XM_054374727.1 → XP_054230702.1  ankyrin repeat domain-containing protein 10 isoform X3

  3. XM_054374726.1 → XP_054230701.1  ankyrin repeat domain-containing protein 10 isoform X2

  4. XM_054374728.1 → XP_054230703.1  ankyrin repeat domain-containing protein 10 isoform X4

RNA

  1. XR_008488773.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NXR5.2 GenPept UniProtKB/Swiss-Prot:Q9NXR5

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